This study explores for the first time how the mutation-independent effect of environmental carcinogens leads to the recruitment of CD8+ T cells, the dominant antitumor cell type. Research raises the possibility of an injection of a chemokine known as CCL21 into a tumor to induce an antitumor response through CD8+ T cells.
Adding an immune checkpoint inhibitor to anti-HER2 treatment in breast cancer does not improve pathological complete response (pCR), according to the primary analysis of the IMpassion050 trial presented today during the ESMO Virtual Plenary. The phase III trial is the first to report data comparing a neoadjuvant anti-HER2 based regimen with or without the anti-PD-L1 antibody atezolizumab in patients with high-risk, HER2-positive early breast cancer.
A Clemson University researcher has developed a protein which links natural killer cells in the human body's immune system to breast cancer cells. It's a novel approach to developing breast cancer-specific immunotherapy and could lead to new treatment options for the world's most common cancer.
Just a small number of cells found in tumors can enable and recruit other types of cells nearby, allowing the cancer to spread to other parts of the body, report Georgetown Lombardi Comprehensive Cancer Center scientists. Working with their research collaborators, the scientists found that 'enabler cells' comprise about 20 percent or less of the cells in an aggressive tumor; their small numbers may account for why they are often missed when bulk tissue analyses are used to inform therapeutic decisions.
Researchers at the University of Kansas found high vaccine hesitancy among women leaving incarceration, a substantial and vulnerable population in the United States. However, a web-based health app proved effective at boosting the group's health literacy.
The prevalence of genetic mutations associated with breast cancer in black and white women is the same.
The delicate strands that carry life's genetic code take a beating as they jumble about in the course of their work. If left untreated, errors accumulate, with fatal consequences for the organism. This is where two key proteins come to the rescue: PARP acts as a marker for a trouble spot, allowing XRCC1 to zoom in and begin a repair.
This survey study among women with breast cancer in Mexico evaluates their specific concerns about and high hesitancy rate toward COVID-19 vaccination.
Two gene variants found in African American women may explain why they are more likely to be diagnosed with triple negative breast cancer (TNBC) than white women of European ancestry, according to Weill Cornell Medicine and NewYork-Presbyterian investigators. The study findings may have implications for developing better risk assessment tools for TNBC in African-American women and for understanding why they have poorer TNBC outcomes.
Scientists studying the link between cholesterol and breast cancer report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles.