Being obese or having a higher body mass index (BMI) while carrying a BRCA (BReast CAncer gene) mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research suggests. The results of the study will be presented Sunday, March 18, at ENDO 2018, the 100th annual meeting of the Endocrine Society in Chicago, Ill.
The decline in cancer of the intestines -- colorectal cancer -- is one of the major success stories of the past 30 years in Europe say researchers, as they predict that in 2018 death rates from the disease will continue to fall by around 7 percent compared to 2012. In a study published in the leading cancer journal Annals of Oncology, researchers predict that death rates in the European Union for most cancers will continue to fall this year, compared to 2012.
A research team from Oregon Health & Science University, led by Joe Gray, Ph.D. and Jim Korkola, Ph.D. discover a tumor's 'microenvironment' plays a critical role in how HER2 positive breast cancer responds to treatment.
An international research consortium led by Dr Jordi Surrallés, director of the Genetics Service at the Hospital de Sant Pau and professor of Genetics at the UAB, and by Dr Miquel Àngel Pujana, director of the ProCURE Research Programme of the Catalan Institute of Oncology (ICO, IDIBELL), has identified a novel gene involved in this type of cancer, known as EDC4.
A research team led by Massachusetts General Hospital investigators has found, for the first time, that obesity and obesity-related molecular factors appear to induce resistance to antiangiogenic therapy in breast cancer patients and in mouse models of the disease.
When compared to the screening population ages 50 and over, screening mammography in women ages 40-49 detects 19.3 percent additional cancers at the expense of an overall 1.5 percent increase in callbacks and 0.1 percent in increased biopsies, according to a study to be presented at the ARRS 2018 Annual Meeting, set for April 22-27 in Washington, DC.
New cutting edge technology can be used to grade cancer tumours, eradicating human subjectivity and ensuring patients get the right treatment.
Resource use intensity for patients in the targeted group was lower in both higher-cost, acute settings such as inpatient and ER as well in the lower acuity outpatient setting, compared to control patients.
These findings led them to hypothesize that antibodies generated against the C-terminus Shh epitope can bind and neutralize full-length Shh found exclusively on the CSC population, while leaving the cleaved N-terminus Shh, important for physiologic Shh signaling, unperturbed.
Scientists have linked 110 genes to an increased risk of breast cancer in the most comprehensive study ever to unpick the genetics of the disease. Their study used a pioneering genetic technique to analyse maps of DNA regions linked to an inherited risk of breast cancer and identify the actual genes involved in raising a woman's risk. Researchers also linked 32 of the new genes to the length of time women survived breast cancer.