A novel precision medicine strategy described in Science Advances offers an intriguing ray of hope for triple-negative breast cancer. The proof-of-concept study shows that dually-targeted, antibody-guided nanoparticles, loaded with an existing chemotherapy drug, markedly improved tumor targeting, decreased tumor and metastatic growth and dramatically improved survival in a mouse model -- with no observable side effects.
The use of digital breast tomosynthesis, also known as 3D mammography, may significantly reduce the number of women who undergo breast biopsy for a non-cancerous lesion following an abnormal mammogram, according to a new study.
Fewer women are assigned to a dense breast category when evaluated with advanced mammographic screening technologies compared to standard digital mammography, according to a new study.
Death rates from breast cancer are predicted to fall in all European Union (EU) countries in 2019 with the exception of Poland, according to new research published in the leading cancer journal Annals of Oncology. In their annual predictions for cancer deaths in the EU, Carlo La Vecchia and colleagues predict there will be 1.4 million deaths from all cancers in 2019.
A team at the George Washington University Cancer Center found that the deubiquitinating enzyme USP15 is a potential biomarker for treatments of pancreatic cancer, as well as ovarian and breast cancers.
It has been known for decades that cancer cells have an altered metabolism and it is seen in several biochemical pathways and in particular, in the way they get energy for their survival. Now, a new article describes an epigenetic injury found in human tumours which created this altered path to take energy from the cancer.
Free fatty acids in the blood are linked with higher rates of estrogen-receptor positive breast cancer in obese postmenopausal women, according to a new study led by food science and human nutrition professor Zeynep Madak-Erdogan at the University of Illinois.
Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones. In addition, they found that synthetic derivatives of stress hormones, which are frequently used as anti-inflammatory in cancer therapy, decrease the efficacy of chemotherapy. These results come from patient-derived models of breast cancer in mice and may have implications for the treatment of patients with breast cancer, as reported in Nature.
The genetic and molecular make-up of individual breast tumours holds clues to how a woman's disease could progress, including the likelihood of it coming back after treatment, and in what time frame, according to a Cancer Research UK-funded study published in Nature.
An imaging technique used to detect some forms of cancer can also help detect preeclampsia in pregnancy before it becomes a life-threatening condition, a new Tulane study says.