The current study demonstrates a deleterious effect of midazolam administration prior to myocardial ischemia and reveals reduced circadian protein Period 2 (PER2) levels as the underlying mechanism. These findings highlight PER2 as a cardioprotective mechanism and suggest the PER2 enhancer nobiletin as preventative therapy for myocardial injury in the perioperative setting where midazolam pretreatment occurs frequently.
The 11th World Stroke Congress brings together leading international stroke experts and an unparalleled scientific program covering epidemiology, prevention, acute care, rehabilitation and recovery in hundreds of sessions and oral posters. Congress is attended by close to 2,500 stroke professionals, researchers, policy makers, survivors and caregivers from around the world.
Macrovascular disease events, which include heart attack and stroke, are a leading cause of illness and death for patients with type 2 diabetes. Medical management, including lifestyle changes, may not reduce patient risk but bariatric surgery may help.
Antiepileptic drug use is associated with an increased risk of stroke among persons with Alzheimer's disease, according to a new study from the University of Eastern Finland. The risk did not differ between old and new antiepileptic drugs. The results were published in the Journal of the American Heart Association.
People with a particular kind of irregular heartbeat called atrial fibrillation may experience a faster decline in thinking and memory skills and have a greater risk of dementia than those without atrial fibrillation, according to a study published in the Oct. 10, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A church-based program to encourage a healthy lifestyle reduced systolic blood pressure more than an educational program alone in blacks with uncontrolled high blood pressure. Delivered by trained lay church members, the faith-based program may help reduce heart disease due to high blood pressure in people with reduced access to medical care.
The updated comprehensive C-CHANGE (Canadian Cardiovascular Harmonized National Guidelines Endeavour) guideline to manage cardiovascular disease will help primary care physicians across Canada provide better care for patients with, or who are at risk of, heart disease. The guideline, published in CMAJ, updates the 2014 guideline, with 52 newly added or updated recommendations.
A culturally tailored program used when discharging stroke patients from the hospital helped to lower blood pressure among Hispanic individuals one year later, finds a new study led by researchers at NYU College of Global Public Health. The almost 10 mm Hg reduction in systolic blood pressure measured in this study has been linked to a nearly 40-percent reduction in the risk of having another stroke in previous studies.
Atrial fibrillation (AFib) patients with a history of cancer are less likely to see a cardiologist or fill anticoagulant prescriptions compared with AFib patients who never had cancer, according to a study in the Journal of the American College of Cardiology. By not filling and taking prescribed medication, these patients are potentially putting themselves at increased risk of stroke.
Individual arm movements are represented by neural activity in both the left and right hemispheres of the brain, according to a study of epilepsy patients published in JNeurosci. This finding suggests the unaffected hemisphere in stroke could be harnessed to restore limb function on the same side of the body by controlling a brain-computer interface.