High-intensity exercise three times a week is safe for individuals with early-stage Parkinson's disease and decreases worsening of the disease's symptoms, according to results of a study published in the Dec. 11 issue of JAMA Neurology.
A 'cure' for hemophilia is one step closer, following results of a groundbreaking gene therapy trial led by Queen Mary University of London and the NHS in London.
Survival benefits of many cancer drug combinations are not due to drug synergy, but to a form of "bet hedging." Combination treatment gives each patient multiple chances of responding to at least one drug, increasing measures of survival within patient populations. Findings suggest new ways to interpret clinical trial data, identify truly synergistic drug pairings and improve the design of combination therapies.
An online database of study summaries could be systematically evaluated to uncover new information about animal testing, including potential targets for efforts to minimize harm to lab animals. A demonstration of this approach is publishing Dec. 14 in the open-access journal PLOS Biology.
The rare, chronic, autosomal-recessive lysosomal storage disease Niemann-Pick disease type C1 (NPC1) is characterized by progressively debilitating and ultimately fatal neurological manifestations. There is an urgent need for disease-modifying therapies that address NPC1 neurological pathophysiology; and passage through the blood-brain barrier represents an important consideration for novel NPC1 drugs.
No matter a patient's smoking history, when a targetable genetic alteration is present, matching the alteration with the appropriate targeted therapy is associated with a survival benefit of 1.5 years.
Researchers have found a new potential treatment that may alleviate complications of babies born smaller than they should be, also called fetal growth restriction, which refers to poor growth of the fetus in the mother's womb during pregnancy. The findings were published in The Journal of Physiology.
Playing an adventure video game featuring a fictitious, young emergency physician treating severe trauma patients was better than text-based learning at priming real doctors to quickly recognize the patients who needed higher levels of care, according to a new trial. The game tackles the annual problem of 30,000 preventable deaths occurring after injury, in part because severely injured patients aren't promptly transferred to trauma centers.
In the first comprehensive analysis of clinical trial enrollment among older adults with blood cancers, researchers from the US FDA found significant gaps in participation among those aged 75 and older when considered against the incidence of these malignancies in this age group, according to research being presented today during the 59th ASH Annual Meeting and Exposition in Atlanta.
High-intensity exercise three times a week is safe for individuals with early-stage Parkinson's disease and decreases worsening of motor symptoms, according to a new phase 2, multi-site trial led by University of Colorado Anschutz Medical Campus and Northwestern Medicine scientists.