Researchers from UNSW Sydney and the Black Dog Institute have questioned the efficacy and safety of intranasal ketamine for depression, with their pilot trial stopped early due to poor side effects in patients.
The Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) trial funded by the Medical Research Council (UK) and ANRS (France) has highlighted the benefits of new therapeutic regimens in the treatment of cryptococcal meningitis, a frequent and severe opportunistic disease in patients living with HIV. In light of these findings, reported in the March 15, 2018, issue of the New England Journal of Medicine, the WHO has changed its guidelines regarding treatment of this fungal infection.
A recent study in 2500 participants in the Offspring cohort of the Framingham Heart Study looked at the value of measuring blood levels of EPA and DHA omega-3 fatty acids to assess an individual's risk for developing certain diseases and determined that the risk for death from any cause was reduced by about 33% in participants with the highest omega-3 blood levels.
Medicinal cannabis is safe and effective in pain relief, and researchers are calling for the treatment to be properly established in our modern medical arsenal. A new special issue of the European Journal of Internal Medicine provides a comprehensive overview of current evidence for the use of cannabis and derived products in medicine, and calls for more research to improve the evidence base for its use.
African-Americans with a common genetic variation are at increased risk for developing Alzheimer's disease, while European-Americans with the same variation are not, according to a study led by researchers at Rush University Medical Center. They published the study results in the Feb. 22 online issue of the Journal of Clinical Endocrinology and Metabolism.
According to a panel of international experts, clinical trials of multimorbidity should measure and report, at minimum, quality of life, mortality, and mental health outcomes.
Diagnostic and treatment advances are helping patients with Duchenne muscular dystrophy live into their 30s and beyond, raising challenges in such areas as education, vocation, levels of independence, personal relationships, emotional health, and intimacy. To address these shifting circumstances, as well as reflect promising new treatment options, new guidelines aimed at physicians who care for DMD patients have recently been issued.
Among people with a type of hole in the heart, known as patent foramen ovale (PFO), those who received a medical device to close this opening after a stroke fared better after two years compared with those who received stroke-preventing medications alone.
Patients with foot ulcers or gangrene who received the experimental drug JVS-100 did not show evidence of faster wound healing, compared with those receiving a placebo, in a study presented at the American College of Cardiology's 67th Annual Scientific Session.
The combined rate of death from any cause, heart attack or stroke within 18 months was not significantly different in patients with acute coronary syndrome (ACS) who were randomly assigned to receive dual antiplatelet therapy (DAPT) for either six months or at least 12 months after receiving a drug-eluting stent.