Through research on the small molecule analogue of E6007 which is under clinical development as a treatment for inflammatory bowel disease, a novel mechanism of action was revealed in which this analogue inhibited the adhesion and infiltration of various leukocytes through the blockade of the interaction between calreticulin and the leukocyte adhesion molecule integrin α by associating with calreticulin.
Videos and creative uses of other visuals provide a novel way to obtain informed consent during clinical trials to improve participants' understanding and retention of trial information, according to a study by Nemours Children's Health System presented at the American Thoracic Society (ATS) Annual Conference.
Kessler Foundation researchers compared two neuropsychological tests for assessing learning in individuals with multiple sclerosis. 'Comparing the Open Trial - Selective Reminding Test results with the California Learning Verbal Test II in Multiple Sclerosis' was published online on April 4, 2018, in Applied Neuropsychology: Adult. This is the first study to compare the two tests in the same individuals with MS.
Stroke remains a leading cause of human disability and rehabilitation therapy can help. Supervised in-home rehabilitation therapy delivered via telemedicine can be as effective as in-clinic rehabilitation program as an alternative for stroke survivors who can't sustain in-person visits for reasons that may include high cost, difficulty traveling to a provider or few regionally available care providers.
A national clinical trial testing a smoking cessation intervention for young adults that was conducted entirely on Facebook has found that smokers are 2.5 times more likely to quit after three months with the Facebook-based treatment than if they were referred to an online quit-smoking program.
South Asians living in the United States are more likely to die of heart conditions caused by atherosclerosis, such as heart attacks and strokes, than East Asians and non-Hispanic whites in the US.
Researchers at Children's Hospital Colorado and the University of Colorado School of Medicine have found that taking a specially formulated antioxidant-enriched multivitamin may decrease respiratory illnesses in people with cystic fibrosis.
A new study has identified several key factors in postmenopausal women that are associated with height loss, a common occurrence in this age group that is known to increase the risk for death and disease.
A novel non-hyperemic index of coronary stenosis severity called resting full-cycle ratio (RFR) was found to be diagnostically equivalent to instantaneous wave-free ratio (iFR) in the VALIDATE RFR study. The results were presented today at EuroPCR, the annual meeting of the European Association of Percutaneous Cardiovascular Interventions, by Ziad A. Ali, M.D., D.Phil., and simultaneously published in EuroIntervention.
An operation that targets the nerves connected to the kidney has been found to significantly reduce blood pressure in patients with hypertension, according to a clinical trial led in the UK by Queen Mary University of London and Barts Health NHS Trust.