The International and American Associations for Dental Research (IADR/AADR) have published a special issue in the Journal of Dental Research (JDR) on orofacial clefting and dental and craniofacial anomalies. Topics in this special issue range from tooth number and root formation, human and animal genetic studies on orofacial clefting, reviews that prioritize the variants most likely to cause disease, the pathways required for palatogenesis, experimental articles on the periderm and drug therapy articles that rescue cleft palate in mutant mice.
Researchers at University of Utah Health clarified a molecular pathway responsible for the formation of cleft palate and identified a new treatment to reverse this defect in mouse pups in utero.
For the first time, investigators have looked at the role that genes and the oral microbiome play in the formation of cavities and have found that your mother was right: The condition of your teeth depends on your dietary and oral hygiene habits. The study appears Sept. 13 in Cell Host & Microbe.
Squid ink could one day make getting checked for gum disease at the dentist less tedious and even painless. By combining squid ink with light and ultrasound, a team led by engineers at the University of California San Diego has developed a new dental imaging method to examine a patient's gums that is noninvasive, more comprehensive and more accurate than the state of the art.
The dental health of middle-aged Americans faces a lot of problems right now, and an uncertain future to come, according to new national poll results. One in three Americans between the ages of 50 and 64 say they're embarrassed by the condition of their teeth, and that dental problems have caused pain or other problems in the past two years. Forty percent of those polled don't get regular cleanings or other preventive oral care.
Researchers at the Bluestone Center for Clinical Research at the New York University College of Dentistry (NYU Dentistry) have identified a novel molecular mechanism which explains why dark-skinned and light-skinned people respond differently to heat and mechanical stimulation.
Professor Hyung Joon Cha and Dr. So Yeong Bahn at Pohang University of Science and Technology, in collaboration with Professor Yoo Seong Choi at Chungnam National University, have shed light on the key mechanism behind the formation of nacre. The team has discovered the role of the matrix protein Pif80 from the pearl oyster Pinctada fucata and its involvement in the development of the nacre.
IADR and AADR have published an article titled 'Periodontitis in Chédiak-Higashi Syndrome: An Altered Immunoinflammatory Response' in the JDR Clinical & Translational Research. In this study sought to determine the periodontal status of patients with severe and mild forms of Chédiak-Higashi syndrome, a rare genetic disorder caused by mutations in the lysosomal trafficking regulator gene -- a gene that codes for a protein that helps with protein packaging and transport within cells.
An herb widely used in traditional Chinese medicine might hold the key to a new osteoporosis therapy that could prevent bone loss without causing side effects. Using a compound derived from red sage, UBC researchers have found a way to selectively block an enzyme called Cathepsin K (CatK), which plays a major role in the breakdown of collagen in bones during osteoporosis.
A new study led by University of Pennsylvania and Technical University of Dresden scientists has identified an important regulator of hematopoeisis, the process of making new blood cells. Targeting it, the researchers noted, could be an effective way to improve stem cell transplants for both donors and recipients.