Researchers at Insilico Medicine, AgeX Therapeutics and the Biogerontology Research Foundation have published a landmark study titled 'Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression of COX7A1 in embryonic and cancer cells' in the journal Oncotarget.
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous pregnancy with better outcomes after a melanoma diagnosis. Now, a research team from Perelman School of Medicine at the University of Pennsylvania says it may have determined the reason for the melanoma-protective effect.
Published in Nature Cell Biology (NCB), the study shows that the EXD2 protein is critical for the mitochondria, the cell's powerhouses, to produce energy. This protein was previously thought to be located in the cell nucleus and to be involved in DNA repair. The results contribute to our basic understanding of mitochondria and suggest that EXD2 could be important for fertility and represent a potential target for cancer therapy.
A new study from Duke Health has found pregnant women experienced less secondhand smoke exposure since the 2009 passage of the 'smoking ban' in North Carolina, which outlawed smoking inside public places such as bars and restaurants.
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to a retrospective cohort study published this week in PLOS Medicine by Krishnarajah Nirantharakumar from the University of Birmingham, UK, and colleagues.
Cervical dilatation during labor for vaginal births can progress more slowly than the widely accepted benchmark of 1 cm/hour in many women, according to a new data published this week in PLOS Medicine.
Two new frog species were discovered in the Amazon Basin. Both had been previously misidentified as another superficially identical species. One of them received a name translating to 'demon' or 'devil' in allusion to the horn-like projections visible on its eyelids. The second one was named in honor of famous American filmmaker Stanley Kubrick, because of his masterpiece A Clockwork Orange. The amphibians are described in the open access journal ZooKeys.
Preterm babies born early in the third trimester of pregnancy are likely to experience delays in the development of the auditory cortex, a brain region essential to hearing and understanding sound, a new study reveals. Such delays are associated with speech and language impairments at age 2, the researchers found.
Researchers have shown for the first time how children can inherit a severe -- potentially fatal -- mitochondrial disease from a healthy mother. The study, led by researchers from the MRC Mitochondrial Biology Unit at the University of Cambridge, reveals that healthy people harbor mutations in their mitochondrial DNA and explains how cases of severe mitochondrial disease can appear unexpectedly in previously unaffected families.
Altered development of a part of the auditory cortex in preterm infants is associated with poorer language skills in early childhood, finds a brain imaging study of very early-born babies in a neonatal intensive care unit. The research, published in eNeuro, suggests that developmental disturbances to this brain region may underlie speech and language difficulties observed in this population.