Seventeen proteins, called the Kidney Risk Inflammatory Signature (KRIS), could allow doctors to determine the risk of progression to end stage renal disease in a patient with diabetic kidney disease.
A low-tech problem troubles the high-tech world of digital pathology imaging: There are no reliable standards for the quality of digitized tissue slides comprising the source material for computers reading and analyzing vast numbers of images. Poor-quality slides get mixed in with accurate slides, potentially confusing a computer program trying to learn what a cancerous cell looks like. Researchers from Case Western Reserve University are trying to fix this, sharing an open-source quality control standard.
Scientists at Christiana Care Health System's Gene Editing Institute and NovellusDx, an Israeli biotechnology company, have deployed a breakthrough CRISPR gene-editing tool to successfully engineer multiple edits simultaneously to fragments of DNA extracted from a human cell, according to a new study published today in The CRISPR Journal. The tool can rapidly reproduce, in a human DNA sample, the unique and complex genetic features of an individual patient's cancer tumor.
Harmonization method developed to reduce site-related differences between neuroimaging data from individual imaging sites and publicly released big data of multiple psychiatric disorders from many imaging sites.
Like other biofluids, sweat contains a wealth of information about what's going on inside the body. However, collecting the fluid for analysis, usually by dripping or absorbing it from the skin's surface, can be time-consuming and messy. Now, researchers have developed a bandage-like biosensor that both collects and -- in conjunction with a smart phone -- analyzes sweat. The device, which could someday help diagnose diseases, is reported in ACS' journal Analytical Chemistry.
Previous research has suggested that specific factors about the doctor performing colonoscopy -- for example, a gastroenterologist versus a surgeon, female versus male -- were associated with different rates of detection of precancerous polyps. However, a Cleveland Clinic-led research team found that those previously described differences among endoscopists are not true.
Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis. To improve that survival rate, researchers at The University of Texas at San Antonio (UTSA) and the University of Texas MD Anderson Cancer Center created an online atlas to identify and classify protein signatures present at AML diagnosis.
Adjusting the frequency and dosage of Parkinson's patients' medication is complex. In their 'ON' state they respond positively to medication and in their 'OFF' state symptoms return. Addressing these fluctuations requires a clinical exam, history-taking or a patient's self-report, which are not always practical or reliable. A new technology that combines an algorithm with a senor-based system using wearable motion sensors, automatically, continuously and reliably detects a patient's medication ON and OFF states without patient or physician engagement.
To improve the treatment of children with irritable bowel syndrome (IBS), investigators have developed a sophisticated way to analyze the microbial and metabolic contents of the gut. A report in The Journal of Molecular Diagnostics, published by Elsevier, describes how a new battery of tests enables researchers to distinguish patients with IBS from healthy children and identifies correlations between certain microbes and metabolites with abdominal pain. With this information, doctors envision tailoring nutritional and targeted therapies that address a child's specific gastrointestinal problems.
UCLA researchers have developed a new artificial intelligence system to help radiologists improve their ability to diagnose prostate cancer.