For the first time, scientists have figured out why drugs that aim to treat Parkinson's disease, migraines, pituitary tumors, and obesity activate the serotonin receptor 5-HT2B to cause life-threatening heart problems. Published in Nature Structure & Molecular Biology, this research provides drug developers with much needed insights into serotonin receptors -- insights that should help scientists create safer more effective drugs, not just for the aforementioned conditions, but also depression, anxiety, and schizophrenia.
Body mass index is positively associated with blood pressure, according to the ongoing study of 1.7 million Chinese men and women being conducted by researchers at the Yale Center for Outcomes Research and Evaluation (CORE) and in China. These findings appear in the Aug. 17 issue of JAMA Network Open.
Proteomic analysis of oocytes from obese mice showed changes in a protein that promotes antioxidant production and may alter meiotic spindles.
Researchers have identified possible ways to uncouple obesity from co-morbidities such as heart disease and insulin resistance.
New research, published in the European Heart Journal, has shown deaths from conditions that affect the blood supply to the brain, such as stroke, are declining overall in Europe but that in some countries the decline is leveling off or death rates are even increasing. Cerebrovascular disease includes strokes, mini-strokes, and narrowing, blockage or rupturing of the blood vessels supplying blood to the brain, and it is the second single largest cause of death in Europe after heart disease.
A study published in the Journal of Bone and Mineral Research shows that the risk of fractures increases by about 30 percent after a gastric bypass operation. It was also discovered that falls increase after these operations.
Adolescents with a strong hand grip -- an indicator of overall muscle strength -- have better odds of being healthy over time, according to a two-year study of 368 elementary school children. The findings give insights to identify youngsters at future risk for developing diabetes and cardiovascular disease.
In a study led by Oklahoma Medical Research Foundation scientist Tim Griffin, Ph.D., researchers found that the carbohydrate composition of diets increased the risk of osteoarthritis in laboratory mice -- even when the animals didn't differ in weight.
New research published in the Journal of Physiology indicates that ketogenic diets, which are low carbohydrate high fat eating plans that are known to lead to weight loss, may cause an increased risk of type 2 diabetes in the early stage of the diet.
After seeing an ad in a campus newspaper promoting unhealthy late-night foods, researchers decided to look at a sample of college students to better understand how drinking affects what they eat.