Discovered more than two decades ago, the hormone leptin has been widely hailed as the key regulator of leanness. Yet, the pivotal experiments that probe the function of this protein and unravel the precise mechanism of its action as a guardian against obesity are largely missing.
Insulin in the brain may help regulate the hunger sensation and improve functional connectivity in certain cognitive brain regions (default-mode network, DMN *) as well as in the hippocampus and hypothalamus. This is the finding of a new study by researchers at the German Center for Diabetes Research (DZD) in Tübingen.
New research overturns long-held views on a basic messaging system within living cells. Key cellular communication machinery is more regionally constrained within the cell than previously thought. The findings suggest new approaches to designing precision drugs. Localizing drug action at a specific 'address' within the cell could mean fewer side effects in treating cancer, diabetes, heart disease and other serious conditions.
Type 2 diabetes (T2D) and osteoporosis often coexist in patients, but managing both conditions can be a challenge. A comprehensive review published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism highlights the most effective treatment options for treating these conditions together.
Results from four recent randomized clinical trials suggest that using medications that offer glucose control while reducing the risk for cardiovascular disease could improve patient outcomes.
Monitoring and maintaining glucose levels of critically ill patients after admission from ICU, to general care through their discharge from the hospital may have positive impact on outcomes.
A position statement on the use of hormone therapy for menopausal and postmenopausal women from The North American Menopause Society (NAMS) has been published online in Menopause. 'The goal of the Society's position statement is to provide excellent, evidence-based, current clinical recommendations to menopause practitioners for the improvement of care for women depending on them to help relieve menopause symptoms,' says Dr. JoAnn Pinkerton, NAMS executive director.
Diabetes is a serious health condition that affects millions of people in the United States and has more than doubled in prevalence over the past 20 years. Diabetes brings a wide array of complications that can harm the cardiovascular system and other organs, and it has been found to affect some groups, such as racial and ethnic minorities and people with low incomes, at a disproportionate rate.
Cell biologists at the University of Toronto have discovered animals can adapt their ability to see even with extreme changes in temperature. The researchers looked deeply into the eyes of catfish living in cold-water streams at altitudes of up to nearly 3 km in the Andes Mountains, and found the protein known as rhodopsin that enables vision in dim light also accelerates the speed at which vision occurs as temperatures drop.
Despite mixed evidence recently about an association between atopic dermatitis and cardiovascular disease, a new study that analyzed more than 250,000 medical records suggests there is no link.