Gabapentin, a nerve pain medication and anticonvulsant sold under the brand name Neurontin and others, increasingly is being misused, necessitating prescribers to understand its abuse potential and risk profile, said Rachel Vickers Smith, Ph.D., M.P.H., assistant professor in the University of Louisville School of Nursing.
Researchers have discovered crucial new processes that allow malaria parasites to escape red blood cells and infect other cells, offering potential new treatment targets. The team are already working with pharmaceutical companies to use this knowledge to develop new antimalarial drugs - a critical step in the battle against drug-resistant malaria.
Blacks have a higher incidence of stroke and stroke-associated disability than whites. However, few studies have evaluated racial differences in stroke before a diagnosis of atrial fibrillation (AF). A new report published in HeartRhythm examined stroke risk in the short term prior to a diagnosis of AF. Investigators determined that, although blacks have a lower risk of developing AF, blacks with AF have a significantly higher risk of stroke during this period compared with whites with AF.
Researchers from the University of Chicago, Harvard University and others show that poor immune responses, not egg adaptions, may explain the low effectiveness of the vaccine that year.
On average, 1 in 10 children who enroll in pediatric phase I cancer trials are improved after the trial, and 1 in 50 die from drug-related complications, according to a new systematic review and meta-analysis published this week in PLOS Medicine by Jonathan Kimmelman from McGill University, Canada, and colleagues.
A study published in the European Respiratory Journal has shown that both moderate and severe exacerbations in COPD patients are associated with a decline in their physical activity level. Researchers observed tha the acute drop in physical activity during a COPD exacerbation has an important and lasting effect.
Amyloid beta pathology -- protein deposits in the brain - might have been transmitted by contaminated neurosurgical instruments, suggests a new UCL-led study. For the paper, published in Acta Neuropathologica, researchers studied the medical records of four people who had brain bleeds caused by amyloid beta build-up in brain blood vessels. All four people had undergone neurosurgery two or three decades earlier as children or teenagers, raising the possibility that amyloid beta deposition may be transmissible.
The team that first unveiled the rapid, inexpensive, highly sensitive CRISPR-based diagnostic tool called SHERLOCK has greatly enhanced the tool's power to work with a miniature paper test, similar to a pregnancy test, allowing rapid and simple detection in any setting. Additional features greatly expand both the breadth and sensitivity of the diagnostic information, including the ability to detect multiple targets at once and quantify the amount of target in a sample.
In patients with Chagas Disease, the odds of being infected by the intestinal worm Strongyloides stercoralis increases by two-fold, according to a study led by the Barcelona Institute for Global Health (ISGlobal). The study, published in Plos Neglected Tropical Diseases, underlines the potential benefits of performing a combined screening for both infections among Latin American adults living in Europe.
Women with asthma who only use short-acting asthma relievers take longer to become pregnant than other women, according to research published in the European Respiratory Journal.