A new computer model that captures the dynamics of the red blood cell sickling process could help in evaluating drugs for treating sickle cell disease.
Iron deficiency in pregnancy is a common problem that often goes unrecognized and untreated due to a lack of knowledge of its implications and competing clinical priorities. To enhance screening and management of iron deficiency in pregnancy, a research team at Toronto's St. Michael's Hospital developed a quality improvement toolkit, called IRON MOM. The implementation of IRON MOM resulted in increased rates of ferritin testing and decreased rates of anemia at St. Michael's obstetric clinics.
The effectiveness of current anti-clotting medication can be limited due to the risk of complications. This is driving a need for alternatives that can both prevent the formation of blood clots and reduce the risk of excessive and life-threatening bleeding. A new biocompatible lab-on-a-chip could help accelerate the discovery and development of new anti-clotting therapies, with automated processes that can achieve in a few minutes what could take days in a full-sized lab.
A researcher at The University of Texas at Arlington has found that blood vessels within bone marrow may progressively convert into bone with advancing age.
An analysis of combined patient-level data from two randomized clinical trials examined outcomes of dual antiplatelet therapy with clopidogrel and aspirin after minor stroke or transient ischemic attack.
Researchers developed a drug delivery system that can break through the blood-brain barrier in mice.
Giant cell arteritis is an inflammation of the blood vessels that typically occurs in adults over 50 and, if left untreated, can result in irreversible vision loss and death. This study examined whether occurrence of the disorder was associated with race.
New data suggest that people who have a parent, sibling, or child with blood cancer have a higher likelihood of being diagnosed with the disease.
Researchers mapped distinct bone marrow niche populations and their differentiation paths for the bone marrow factory that starts from mesenchymal stromal cells and ends with three types of cells -- fat cells, bone-making cells and cartilage-making cells. Respectively, those cells are called adipocytes, osteoblasts and chondrocytes. This non-hematopoietic cell system is distinct from another production line in the bone marrow -- the hematopoietic system -- that makes red blood cells, blood-clotting cells and cells of the immune system.
Rheumatoid arthritis is a progressive autoimmune disease most frequently characterized by pain, swelling, and stiffness in joints. Here, increased numbers of OX40-expressing follicular helper T cells, accompanied by autoantibodies with an increased inflammatory ability, were found during the onset of experimental arthritis. A University of Tsukuba-led research team found that OX40-expressing follicular helper T cells contributed to inflammation by regulating sialylation of autoantibodies, and that blockage of this mechanism could reduce inflammation in experimental arthritis.