International research consortium led by researchers from the University of Helsinki, Finland, discovered new information related to a rare form of leukemia called aggressive NK-cell leukemia. Potential new treatment options were found which are highly warranted as currently this disease usually leads to rapid death of patients.
St. Jude Children's Research Hospital scientists have discovered a fourth gene that can predispose carriers to the most common childhood cancer, expanding the list of genes to include in cancer screening.
Adolescents and young adults with acute leukemia have a survival advantage if they receive treatment at a pediatric cancer center versus an adult center, according to a new study.
Majority of patients with the most severe thalassemia are transfusion-free years after gene therapy that uses the patient's own stem cells.
Chronic lymphocytic leukaemia (CLL) is a haematological malignancy. When infiltrating tissues, CLL cells come in contact with healthy cells, including immune cells. Researchers from the Luxembourg Institute of Health (LIH) succeeded in characterising in depth the composition of immune cells and circulating cytokines of the CLL microenvironment in mouse models using mass cytometry. Based on this knowledge, they propose an immunotherapeutic strategy with two immune checkpoint inhibitors that efficiently blocks disease development in preclinical tests.
The immunotherapy drug pembrolizumab, combined with chemotherapy, doubles survival in patients with non-squamous non-small cell lung cancer (NSNSCLC) lacking genetic changes in the EGFR or ALK genes, when compared to chemotherapy alone, according to an international, Phase III clinical trial.
A University of British Columbia bioengineer has endowed platelets with extra powers to make the clotting process more resilient in the face of trauma. If it's proven to work in clinical situations, such 'superplatelets' might become a standard part of emergency department supplies, along with bandages, oxygen and saline.
A new type of cancer vaccine has yielded promising results in an initial clinical trial. The personalized vaccine is made from patients' own immune cells, which are exposed to the contents of the patients' tumor cells, and injected into the patients to initiate a wider immune response. The trial, conducted in advanced ovarian cancer patients, showed that about half of the vaccinated patients had signs of anti-tumor T-cell responses. The study is published today in Science Translational Medicine.
The so-called good cholesterol, HDL, is associated with infectious disease, new research from the University of Copenhagen and Copenhagen University Hospital shows.
Scientists have long theorized that blood flow plays an integral role in cancer metastasis. But new research, published April 9 in Development Cell, testing this long-held hypothesis in zebrafish and humans confirms that the circulatory blood flow impacts the position where circulating tumor cells ultimately arrest in the vasculature and exit into the body, where they can form a metastasis.