After completing up to four years of egg oral immunotherapy (eOIT) treatment, certain participants were able to safely incorporate egg into their diet for five years. This new research was presented by the study's first author, Edwin Kim, MD, at the annual American Academy of Allergy, Asthma and Immunology (AAAAI) conference in San Francisco.
The original hypothesis was that humans developed the red meat allergy after being exposed to the alpha-gal protein through a tick that had fed previously on a small mammal. But new data suggests ticks can induce this immune response without requiring the mammal blood meal, which likely means the risk of each bite potentially leading to the allergy is higher than doctors had anticipated.
Children exclusively breastfed for the first three months of life had significantly lower odds of having eczema at age 6 compared with peers who were not breastfed or were breastfed for less time, according to preliminary research presented during the American Academy of Allergy, Asthma & Immunology 2019 Annual Meeting.
An international research team led by Friedrich Schiller University in Jena has developed a highly sensitive cell model to study the complex effects -- and side effects -- of anti-inflammatory drugs, with the ultimate aim of preventing chronic inflammation.
Writing in the journal Cell, a research team from Cologne and Kiel describes the mechanism of 'immune cross-reactivity'. The immune system's reaction to Candida albicans in the intestine seems to amplify pathogenic immune processes in the lungs. In consequence, immune-compromised individuals may be at higher risk of health deterioration.
Researchers have identified an unexpected contributor to rheumatoid arthritis that may help explain the painful flare-ups associated with the disease. The discovery points to a potential new treatment for the autoimmune disorder and may also allow the use of a simple blood test to detect people at elevated risk for developing the condition.
Researchers have engineered 'antibody-like' T cell receptors that can specifically stick to cells infected with cytomegalovirus, or CMV, a virus that causes lifelong infection in more than half of all adults by age 40. These receptors represent a new potential treatment option, could aid the development of CMV vaccines and might also be used to target brain tumors.
An Osaka University-led research team assayed T cell cytotoxicity in tumor tissue in lung cancer, along with normal lung tissue and peripheral blood. They found associations of tumor T-cell cytotoxicity with smoking and cytokine levels. They also revealed that T-cell cytotoxicity in peripheral blood correlated with that in tumors, and also with the effectiveness of nivolumab in cancer immunotherapy. These findings provide a simple tool for predicting immune checkpoint inhibitor efficacy in individual lung cancer patients.
Hesperos reports the successful testing of multi-organ 'human-on-a-chip' models to recapitulate the 28-day experiments typically used in animals to evaluate the systemic toxicity of drug and cosmetic compounds. The work is published in Advanced Functional Materials.
An analysis of cervical precancers over a period of seven years showed that two strains of human papillomavirus (HPV) that have been targeted by vaccination since 2006 have declined, accounting for a smaller proportion of cervical disease. The study offers evidence that HPV vaccination reduced the incidence of infections that can lead to cervical cancer.