In a new study published in Science Immunology, researchers from Brigham and Women's Hospital and Monash University in Australia reveal new insights into the basis for T cell receptor (TCR) autoreactivity to self-phospholipids, with implications for autoimmune diseases.
A new vaccine under development provoked an immune response to 72 forms of the bacteria that's responsible for pneumonia, sepsis and meningitis. That's up from the 23 forms of bacteria covered by current immunizations. The new vaccine, which represents the 'most comprehensive' coverage of pneumococcal disease to date, could greatly reduce the number of deaths from the disease.
Flu viruses contain defective genetic material that may activate the immune system in infected patients, and new research published in PLOS Pathogens suggests that lower levels of these molecules could increase flu severity.
Patients suffering injuries in low and middle-income countries have a higher prevalence of HIV than baseline populations and HIV Infection may be associated with greater risk of post-injury mortality.
In 2013, an influenza virus began circulating among poultry in China. It caused several waves of human infection and as of late July 2017, nearly 1,600 people had tested positive for avian H7N9. Nearly 40 percent of those infected had died. In 2017, Yoshihiro Kawaoka of the University of Wisconsin-Madison received a sample of H7N9 virus isolated from a patient in China who had died of the flu. He and his research team subsequently began work to characterize and understand it.
New statistical simulations suggest that Northern Hemisphere flu pandemics are most likely to emerge in late spring or early summer at the tail end of the normal flu season, according to a new study published in PLOS Computational Biology by Spencer Fox of The University of Texas at Austin and his colleagues, Lauren Ancel Meyers (also at UT Austin) and Joel C. Miller at the Institute for Disease Modeling in Bellevue, Wash.
The FDA today approved the use of a breakthrough cancer treatment for adult patients with relapsed or refractory diffuse large B-cell lymphoma, a form of non-Hodgkin lymphoma. The treatment is a form of CAR T-cell therapy now labelled Yescarta (axicabtagene ciloleucel). The University of Chicago Medicine is the first site in Illinois certified by both Kite Pharma Inc. and Novartis.
In a new study, a team from the University of Pennsylvania describes how X chromosome inactivation is regulated in the immune system's B cells as they develop in bone marrow and when they encounter antigens.
Scientists have found that stem cells in the skin remember an injury, helping them close recurring wounds faster. The discovery could advance research and treatment of psoriasis and other inflammatory diseases.
Duplications of large segments of noncoding DNA in the human genome may have contributed to the emergence of differences between humans and nonhuman primates, according to results presented at the American Society of Human Genetics (ASHG) 2017 Annual Meeting in Orlando, Fla. Identifying these duplications, which include regulatory sequences, and their effect on traits and behavior may help scientists explain genetic contributions to human disease.