Attention has focused on how NSAIDs may cause dysfunction of the immune system. Researchers now have found that sub-acute pretreatment with the NSAID carprofen before experimental heart attack in mice impaired resolution of acute inflammation following cardiac injury. They focused on three aspects of the inflammation resolution axis -- cardiac function, leukocyte profiling and inflammation-resolution markers.
In search of an option for the drug known for causing several side effects, scientists describe the anti-inflammatory properties of protein galectin-1 in tests with rats involving ischemia-reperfusion scenarios.
The STING protein is normally an important part of our immune system, but in some autoimmune diseases it is itself the source of the disease. The pharmaceutical industry is therefore engaged in a race to find a drug that can inhibit STING. Now, researchers from Aarhus may have found it.
During the month of July, a total of 758 cases of measles were reported across seventeen countries in the EU/EEA, which is a decrease from the 1054 cases reported during the month of June.
A novel study indicates promising avenues in an innovative approach for developing a vaccine against Plasmodium vivax, the most prevalent human malaria parasite outside sub-Saharan Africa. The study, led by researchers from the Barcelona Institute for Global Health, indicates the possibility of using small vesicles (or exosomes) secreted by immature red blood cells as a vaccine platform against malaria. The paper, carried out in collaboration with IrsiCaixa AIDS Research Institute, was published in Scientific Reports.
Researchers from Newcastle University and Demuris Ltd have identified that a naturally occurring antibiotic, called kanglemycin A -- related to the antibiotic rifampicin -- is active against rifampicin-resistant Mycobacterium tuberculosis.
New high-resolution maps pinpoint areas across Africa with concentrations of child deaths from diarrhea and show uneven progress over 15 years to mitigate the problem. The study, covering 2000 to 2015, maps the entire African continent in 5x5 square kilometer units and was published today in The New England Journal of Medicine. National and provincial maps of diarrhea in Africa often mask inequalities at the local community level, according to IHME researchers.
Investigators have assessed the prevalence of treatable traits in severe asthma and have determined which specific traits are predictive of future asthma attacks. Their findings, which are published in Respirology, are the result of an extensive national collaborative study in Australia.
Infection with human papillomavirus (HPV) can cause certain cancers in women and men, but HPV vaccines are highly effective in preventing infection with oncogenic HPV types. A new British Journal of Clinical Pharmacology review of post-licensure data did not identify any new or unexpected safety concerns of the bivalent HPV vaccine.
Researchers at The University of Texas Medical Branch at Galveston have successfully harnessed their Zika virus vaccine to target and kill brain cancer known as glioblastoma.