For the first time, immunologists have captured on video what happens when T cells undergo a type of assassin-training program before they get unleashed in the body. A new imaging technique that allowed for the videos, described today in the journal Nature Communications, holds promise for the fight against autoimmune disorders such as Type 1 diabetes.
In a review published May 17, 2019 in the journal Trends in Immunology, researchers discuss how time of day affects the severity of afflictions ranging from allergies to heart attacks.
An app that allows parents and doctors to monitor a child's asthma has a big impact on managing the disease. When families monitored symptoms with eAsthma Tracker and adjusted care accordingly, children had better asthma control and made fewer visits to the emergency department. Using the app also meant that children missed fewer days of school and parents took fewer days off work, improving quality of life. Results of the study were published online in the journal Pediatrics.
Current vaccination policies may not be sufficient to achieve and maintain measles elimination and prevent future resurgence in Australia, Ireland, Italy, the UK and the US, according to a study published in the open access journal BMC Medicine.
Antiviral antibodies produced by survivors of Ebola infection continue to evolve and improve after recovery, according to a study of immune responses in four people who received care at Emory University Hospital in 2014. High levels of neutralizing antibodies- thought to be key to protecting someone against deadly infection -- didn't appear in patients' blood until months after they left the hospital.
Researchers at The University of Chicago have demonstrated that the type of bacteria living in the gut can influence the development of Alzheimer's disease symptoms in mice. The study, which will be published May 16, 2019 in the Journal of Experimental Medicine, shows that, by altering the gut microbiome, long-term antibiotic treatment reduces inflammation and slows the growth of amyloid plaques in the brains of male mice, though the same treatment has no effect on female animals.
The quantity and quality of antibodies recognizing the end region of the malaria parasite's CSP protein is a good marker of protection by the RTS,S/AS01E vaccine, shows a study led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by 'la Caixa.' The results provide valuable information for guiding the design of future, more effective vaccines.
Therapies that harness the power of the immune system against cancer have made remarkable progress against certain tumors but still remain ineffective in most cancer patients. A new study from the Massachusetts General Hospital Center for Immunology and Inflammatory Diseases describes a method of reprogramming regulatory T cells that usually suppress immune responses into inflammatory cells that not only permit but also intensify an antitumor immune response.
The existence of certain microorganisms in your gut may bolster the immune system's ability to fend off a herpes viral attack that can cause fatal brain inflammation. Researchers say the findings are the first to suggest that an envelope molecule from a bacterium called Bacteroides fragilis (B. fragilis) might be useful against viral inflammatory diseases. Called capsular polysaccharide A (PSA), the envelope molecule appears to promote protective, anti-inflammatory responses during a viral infection.
Stressful life events most likely contribute to autoimmune diseases, but scientists don't have a deep understanding of the underlying chain of events. A study on mice published this week in mSystems suggests that the gut microbiota may play a significant role in that connection. Researchers found that the onset of stress caused changes in the intestinal bacteria that, in turn, stimulated the activity of immune cells in a way that increased the likelihood that the body would attack itself.