The field of immunotherapy is moving forward at an unprecedented rate and cancer immunotherapy, in particular, has recently come of age!
In collaboration with teams from the Czech Republic and Japan, researchers from the Institut Pasteur, (AP-HP), and (AP-HM) have identified the likely origin of the cross-reactivity between cypress pollen, peaches and citrus fruits. Their work has shown that these sources contain allergens belonging to a new family of proteins involved in pollen food associated syndrome. This discovery, published in JACI on Aug. 3, paves the way for the development of novel allergy diagnostic tests.
Thanks to a secret vaccine ingredient as well as a net of worldwide researchers and successful vaccination campaigns, smallpox was finally eradicated in 1977. A new study entitled 'Revisiting Jenner's mysteries, the role of the Beaugency lymph in the evolutionary path of ancient smallpox vaccines' and published in The Lancet Infectious Diseases, provides an in-depth investigation of the mysteries associated with the development of smallpox vaccine and is a rich and interesting account of how the vaccine lymph was spread worldwide.
Adding another reason for doctors to avoid the overuse of antibiotics, new research shows that a reduction in the variety of microbes in the gut interferes with the immune system's ability to fight off disease.
A drug-like molecule developed by Duke Health researchers appears to intercede in an inflammatory response that is at the center of a variety of diseases, including some cancers, rheumatoid arthritis and Crohn's disease.
University of Alberta researchers have found that peroxisomes are required for cells in the innate immune response to bacteria and fungi. Research Associate Francesca Di Cara, together with Richard Rachubinski, professor and chair of the Department of Cell Biology, and Andrew Simmonds, cell biology associate professor, found that peroxisomes are necessary for proper functioning of the innate immune system, the body's first line of defense against microorganisms.
A study led by Wistar scientists describes a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer-specific protein.
Hemorrhagic fevers are severe viral diseases that are often fatal. Researchers from the University of Basel have now identified messenger substances of the immune system, which in infected mice lead to the development of shock. These results, published in the scientific journal Cell Host & Microbe, open up new possibilities for the development of life-saving therapies.
Molecular biologists led by Leonid Pobezinsky and his wife and research collaborator Elena Pobezinskaya at the University of Massachusetts Amherst have published results that for the first time show how a microRNA molecule known as Lethal-7 (let-7) serves as a molecular control hub to direct the function of cytotoxic T lymphocytes by putting the brakes on their cell-killing activities.
An ECDC expert opinion concludes that there is clear evidence supporting the use of neuraminidase inhibitors in the treatment and prevention of influenza. Moreover, the current recommendations in European countries on the use of the neuraminidase inhibitors oseltamivir and zanamivir are appropriate and should be applied by prescribing physicians.