Brazil is in the midst of a yellow fever outbreak, with the mosquito-borne virus reaching popular tourist destinations that do not normally see the disease. Since January 2018, 10 cases of yellow fever have been confirmed in international travelers visiting Brazil, including four deaths.
Research from the University of Liverpool, published in Lancet Respiratory Medicine, identifies a genetic variant that could improve the safety and effectiveness of corticosteroids, drugs that are used to treat a range of common and rare conditions including asthma, and chronic obstructive pulmonary disease (COPD).
People's willingness to use a Zika vaccine, once it's available, will be influenced by how they weigh the risks associated with the disease and the vaccine, but also by their misconceptions about other vaccines.
The ability of the 'cold sore' herpes simplex virus to establish quiet infections and reawaken periodically has long mystified scientists. A new study in mice reveals that a key host protein acts as a critical regulator of the virus's sleep-wake cycle.
In a study conducted in rural India, Johns Hopkins Medicine researchers working in collaboration with Bal Umang Drishya Sanstha (BUDS), a nonprofit Indian organization focused on child health, have found that mobile phone reminders linked with incentives such as free talk time minutes work better than phone alerts alone to improve childhood immunization rates in poor communities.
MIT engineers have developed new technology that could be used to evaluate new drugs and detect possible side effects before they are approved for human use. Using a microfluidic chip that connects tissue samples from up to 10 organs, the researchers can accurately replicate human organ interactions, allowing them to measure the effects of drugs on different parts of the body.
Eric Skaar, Ph.D., M.P.H., and colleagues at Vanderbilt have combined multiple types of molecular imaging to probe an invasive Staphylococcus aureus infection in the mouse. Their integrated imaging approach, reported this week in Science Translational Medicine, revealed new insights about staph infections and can be broadly applied to any health or disease state.
Ashley Boyle, an associate professor of medicine at the University of Pennsylvania's School of Veterinary Medicine, took the lead in writing a new consensus statement, issued by the American College of Veterinary Internal Medicine, on treating, controlling, and preventing strangles in horses.
Neuron myelination is critical to early mental development, and defects in myelination have been linked to neurodevelopmental disorders. Researchers at Osaka University found that B immune cells reside in the brains of developing mice, and play a key role in the myelination of neurons by oligodendrocytes. The findings suggest a new avenue of exploration for understanding the origin of disorders such as autism and schizophrenia.
In the April edition of the Journal of Clinical Investigation, a team led by Associate Professor John Miles from James Cook University and Cardiff University's Professor Andrew Sewell describe how they engineered a new vaccine production platform and built a fully synthetic flu vaccine.