Nearly 100,000 new cases of melanoma are diagnosed annually, and 20 Americans die every day from it. Now, researchers have developed a skin patch that efficiently delivers medication within one minute to attack melanoma cells. The device, tested in mice and human skin samples, also could be adapted to deliver other vaccines. The scientists present their findings today at the American Chemical Society Fall 2019 National Meeting & Exposition.
Researchers have uncovered a crucial link between dietary zinc intake and protection against Streptococcus pneumoniae, the primary bacterial cause of pneumonia. Globally, it is estimated that nearly two billion people suffer from zinc deficiency, but why this increases susceptibility to bacterial infection has not been well understood -- until now.
The growing number of children arriving at Texas schools unvaccinated makes the state increasingly vulnerable to measles outbreaks in cities large and small, according to a computer simulation created by the University of Pittsburgh Graduate School of Public Health. The findings indicate that a 5% further decrease in vaccination rates that have been on a downward trend since 2003 would increase the size of a potential measles outbreak by up to 4,000% in some communities.
Four in 10 parents say they are very or somewhat likely to move their child to a different provider if their doctor sees families who refuse all childhood vaccines, according to a new national poll.
Giving children an additional dose of rotavirus vaccine when they are nine months old would provide only a modest improvement in the vaccine's effectiveness in low-income countries, according to a new study led by the Yale School of Public Health and the Institute of Infection and Global Health at the University of Liverpool.
A team led by the Walter Reed Army Institute of Research has gained new insights into the mechanism of vaccine-induced T cell immunity, including regulation, gene expression and metabolic pathways. This study, published in Nature Communications, used samples from a Phase 1 clinical trial for TAK-003, a live-attenuated tetravalent dengue vaccine. Though these discoveries occurred in the context of a dengue vaccine trial, they are applicable to the development of vaccines for numerous viral diseases.
A new study shows that the risk of giving birth to a child with microcephaly might be related to how the immune system reacts against the Zika virus -- specifically what kind of antibodies it produces.
New research led by scientists at The Rockefeller University in New York may help explain why Zika virus infection causes birth defects in some children but not others. The study, which will be published August 14 in the Journal of Experimental Medicine, suggests that the risk of developing an abnormally small head (microcephaly) depends on the types of antibody produced by pregnant mothers in response to Zika infection.
Walter and Eliza Hall Institute researchers have identified a molecular switch that impacts immune responses to viral infections, and whether or not protective antibodies are produced. The team also made the surprising discovery that the immune system protects against different viruses via distinct pathways. Their findings could lead to better strategies to develop vaccines for previously hard-to-prevent viruses.
The RTS,S malaria vaccine could enhance the production of protective antibodies upon subsequent parasite infection, according to a study led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by 'la Caixa.' The results, published in BMC Medicine, identify the antigens (or protein fragments) that could be included in future, more effective multivalent vaccines.