A study led by Wistar scientists describes a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer-specific protein.
An ECDC expert opinion concludes that there is clear evidence supporting the use of neuraminidase inhibitors in the treatment and prevention of influenza. Moreover, the current recommendations in European countries on the use of the neuraminidase inhibitors oseltamivir and zanamivir are appropriate and should be applied by prescribing physicians.
Princeton University researchers have uncovered a critical role for a new immune signaling pathway in controlling infection by the flavivirus Yellow Fever Virus (YFV).
Plants have been used to produce a new vaccine against poliovirus in what is hoped to be a major step towards global eradication of the disease.
A new study describes how NS1, a protein produced by influenza A viruses, suppresses the body's immune responses to viral infection.
Myxoma virus -- introduced to control the rabbit population in Australia in 1950 -- has developed a deadly ability to suppress the immune response in host rabbits. This example of an evolutionary arms race highlights the potential for escalating virus virulence and host resistance to produce more dangerous viruses with implications for agriculture and human vaccination, where resistance to viruses is artificially increased through selective breeding, genetic engineering, and immunization, potentially accelerating the arms race.
The team from Instituto de Medicina Molecular Lisboa, led by Luis Graça, analyzed blood samples from Sjögren syndrome patients, an autoimmune disease that affects the mucous membranes and moisture-secreting glands of the eyes and mouth, and found that these patients have a significant increase in a specific type of immune cells called T follicular regulatory cells (Tfr).
Following the introduction of routine childhood vaccination against rotavirus, a common cause of diarrheal illness, more than 380,000 children avoided hospitalization for diarrhea from 2008 to 2013 in the US, thus saving an estimated $1.2 billion in direct medical costs. The estimates, from a new study published in the Journal of the Pediatric Infectious Diseases Society, provide additional evidence for the substantial impact of routine rotavirus vaccination.
Current strategies for correcting misinformation about the dangers of vaccinations have the opposite effect and reinforce ill-founded beliefs, a study suggests.
Rhesus macaques previously infected with dengue or yellow fever viruses appear to be neither more nor less susceptible to severe infection with Zika virus, according to new research published in PLOS Pathogens.