Researchers at the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children have discovered novel genes and pathways related to early stages in the development of celiac disease and the ongoing inflammation and comorbidities associated with the condition.
Scientists from Lancaster University have discovered that immune responses originally found to prevent fungal infections are also important in eliminating Trichinella spiralis, a round worm and the causative agent of Trichinosis. People acquire trichinellosis by consuming raw or undercooked meat infected with the Trichinella parasite, particularly wild game meat or pork.
In the first study of its kind in the US, researchers found that normally developing preschool children with chronic constipation have underlying sensory issues that contribute to their difficulties with toileting behaviors. These children are often picky eaters who might be overly sensitive to food textures, tastes, or odors. They also might have an exaggerated response to noises, bright lights, or other sensory stimuli. Findings were published in the Journal of Pediatrics.
University of Sydney researchers have developed a model that can predict salmonella outbreaks several months in advance, and its results come as a warning ahead of the Easter long weekend.
Investigators from Brigham and Women's Hospital and MIT are designing devices that can be triggered by the ingestion of a warm liquid to break down into smaller segments that can be excreted.
Giovanna Guidoboni, Marjorie Skubic and a team at the University of Missouri are currently working to develop a standardized model to interpret the results of a ballistocardiogram that could provide an additional approach for early detection of various cardiovascular diseases.
IDIBELL -- ICO researchers in Barcelona have found that inactivation of two proteins make tumoral cells more sensitive to chemotherapy. This sets new bases to develop therapies against colorectal cancer.
Previous research has suggested that specific factors about the doctor performing colonoscopy -- for example, a gastroenterologist versus a surgeon, female versus male -- were associated with different rates of detection of precancerous polyps. However, a Cleveland Clinic-led research team found that those previously described differences among endoscopists are not true.
To improve the treatment of children with irritable bowel syndrome (IBS), investigators have developed a sophisticated way to analyze the microbial and metabolic contents of the gut. A report in The Journal of Molecular Diagnostics, published by Elsevier, describes how a new battery of tests enables researchers to distinguish patients with IBS from healthy children and identifies correlations between certain microbes and metabolites with abdominal pain. With this information, doctors envision tailoring nutritional and targeted therapies that address a child's specific gastrointestinal problems.
Using CRISPR gene editing, a team has thwarted a lethal lung disease, in an animal model, in which a harmful mutation causes death within hours after birth. This proof-of-concept study showed that in utero editing could be a promising new approach for treating lung diseases before birth.