No matter a patient's smoking history, when a targetable genetic alteration is present, matching the alteration with the appropriate targeted therapy is associated with a survival benefit of 1.5 years.
Biochemists at the University of Zurich have used cryo-electron microscopy to determine the detailed architecture of the chloride channel TMEM16A. This protein is a promising target for the development of effective drugs to treat cystic fibrosis.
PTEN, a tumor suppressor, helps clear lung infections when attached to a protein in lung tissue. But in cystic fibrosis, the protein is mutated, and doesn't latch onto PTEN.
Children between the ages of 7 and 9 may be at greater risk for developing asthma if they consumed high amounts of fructose in early childhood or their mothers drank a lot of sugar-sweetened beverages while pregnant, according to new research published online in the Annals of the American Thoracic Society.
Exposure to air pollution on city streets is enough to counter the beneficial health effects of exercise in older adults, according to new research.
This month marks the 50th anniversary of the world's first human heart transplant performed at Groote Schuur Hospital in Cape Town by South African surgeon, Christiaan Barnard. He transplanted the heart of a 25-year-old woman into Louis Washkansky, a 53-year-old diabetes patient who was in severe heart failure. A special issue of The Journal of Heart and Lung Transplantation presents a chronicle of the major milestones in heart transplantation over the last 50 years.
Thyroid hormone therapy significantly resolves fibrosis, or scarring, in the lungs of mice, increasing their survival from disease, a Yale-led study shows. These provide a novel insight into the development of pulmonary fibrosis and could lead to alternative treatment for this serious condition, according to the researchers.
A modified version of iPS methodology, called interrupted reprogramming, allows for a highly controlled, safer, and more cost-effective strategy for generating progenitor-like cells from adult cells. As demonstrated in Stem Cell Reports, researchers converted adult mouse respiratory tract cells called Club cells into large, pure populations of induced progenitor-like cells, which retained a residual memory of their parental cell lineage. Moreover, these cells showed potential as a cell replacement therapy in mice with cystic fibrosis.
Massachusetts General Hospital investigators have identified a way in which a type of lung cancer co-opts a portion of the immune system to increase tumor progression.
In a New England Journal of Medicine perspective, experts from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and the World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza in Melbourne discuss how the process of preparing seasonal influenza vaccines in eggs may contribute to their limited effectiveness. The authors offer research strategies that might yield more protective vaccine candidates.