How does a normal cell turn into a deadly cancer? Seeking an answer to this Question researchers from Charité -- Universitätsmedizin Berlin examined the tumor genomes of nearly 300 prostate cancer patients. Their findings describe the ways in which changes in the prostate cells' genetic information pave the way for cancer development. Using a newly developed computer model, it is now possible to predict the course of the disease in individual patients. The results of this study were now published in Cancer Cell.
Genetically diverse bacterial strains that cause urinary tract infections differ in their ability to trigger protective immune responses in mice, potentially explaining why these infections frequently recur in many patients, according to a study published Dec. 13 in the open-access journal PLOS Pathogens by Thomas Hannan and Scott Hultgren of Washington University School of Medicine, and colleagues.
As more and more parents travel overseas to find a surrogate, a new study published in Human Fertility is the first to compare the experiences of those who carry out surrogacy in the UK with those who go abroad. The research highlights important problems faced by parents, which could influence UK surrogacy law.
Patients with albuminuria will usually need more than one drug to achieve blood pressure control, particularly if the aim is also to reduce albuminuria.
Researchers have uncovered an increased risk of cervical cancer in women whose cervical cells test positive for certain high-risk human papillomavirus (HPV) types but do not show any signs of cellular abnormalities. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings may help refine guidelines for cervical cancer screening.
For the first time, scientists have described the body's natural mechanism for temporarily protecting the powerhouses of kidney cells when injury or disease means they aren't getting enough blood or oxygen.
Medical software developed at UCL that overlays tumour information from MRI scans onto ultrasound images can help guide surgeons conducting biopsies and improve prostate cancer detection.
A research team has developed a non-invasive method for detecting bladder cancer that might make screening easier and more accurate than current invasive clinical tests involving visual inspection of bladder. In the first successful use of atomic force microscopy (AFM) for clinical diagnostic purposes, the researchers have been able to identify signature features of cancerous cells found in patients' urine by developing a nanoscale resolution map of the cells' surface.
Patients who experience disturbances in sleep, mobility, nutrition or mood while admitted in hospital may be more likely to be readmitted within 30 days after discharge, finds a new study co-led by St. Michael's Hospital and the University Health Network (UHN) in Canada.
Preclinical experiments suggest the cancer drugs vorinostat, belinostat and panobinostat might be repurposed to treat infections caused by human papillomaviruses, or HPVs. Highly efficacious vaccines against HPV infection exist -- including the recently approved Gardasil 9, which immunizes against nine genotypes of HPV known to cause cervical, vulvar, vaginal and anal cancers. But the vaccine needs to be given before a person becomes sexually active, since it has no therapeutic efficacy against existing HPV infections.