Patients with lupus are at increased risk of heart disease. Exposing endothelial cells -- known to protect against heart disease, in part by producing nitric oxide -- to the serum of patients with lupus decreased nitric oxide production. Administering L-sepiapterin restored that production. These findings, reported by Medical University of South Carolina researchers in Lupus Science & Medicine, provide proof-of-concept that the enzyme is a promising therapeutic target for heart disease in lupus and beyond.
- Lupus Science & Medicine
- NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute of Dental and Craniofacial Research, NIH/National Institute of Arthritis and Musculoskeletal Diseases, National Institutes of Health, VA Merit Award