By turning off an important step of cellular recycling, metastatic cancer cells become unable to survive the stresses of traveling through the body.
All women should be screened annually for urinary incontinence, according to new guidelines from the Women's Preventive Services Initiative (WPSI). Screening should assess whether women experience urinary incontinence and whether it affects their activities and quality of life. If treatment is indicated, women should be referred for further evaluation. The clinical guideline and evidence review are published in Annals of Internal Medicine.
Men who wear boxer shorts have higher sperm concentrations than men who wear tighter fitting underwear, according to new research published in Human Reproduction. The study differs from previous research on this topic because it includes a larger number of men (656) than previous studies, and because it is the first to go beyond the traditional, narrow focus on semen quality and include information on a variety of indicators of testicular function, such as reproductive hormones and sperm DNA damage.
Using a manmade version of a human antibody to directly deliver a drug that inhibits a powerful driver of inflammation, can reverse a disease course that often leads to kidney failure and dialysis, investigators report.
Childhood nephrotic syndrome is the most frequently occurring chronic kidney disease among children. A Japanese research team has identified a group of genes that are strongly related to the development of childhood nephrotic syndrome. The results of this study could shed light on the underlying mechanism for this disease. These findings were published on July 16 in the online edition of Journal of the American Society of Nephrology.
Scientists have known for some time that one of the reasons a staph infection is so deadly is that the bacteria send out a toxin, known as Alpha Toxin (AT), which quickly worsens sepsis. University of Calgary scientists at the Cumming School of Medicine's Snyder Institute for Chronic Diseases have discovered the most important target of the toxin and how to neutralize the danger.
The lifespan of a transplant kidney has significantly improved over the last thirty years. Between 1986 and 1995, 75 percent of the transplanted kidneys still functioned five years after the transplant. Between 2006 and 2015, this number had already risen to 84 percent. However, an international study lead by kidney specialist Maarten Naesens of KU Leuven shows that the progress is stagnating.
Scientists have discovered that some treatments for cancer and sickle cell disease can destroy the germ cells that go on to develop into sperm in the testes of young boys. In some pre-pubescent boys, the treatment for sickle cell disease results in complete destruction of all their germ cells, which are called spermatogonia. The study is published in Human Reproduction and is the first to describe the effects of these treatments on spermatogonial quantity
Recent research in the Journal of Lipid Research addresses complex questions ranging from enzyme mechanisms to the epidemiology of noncommunicable diseases.
The high number of reported complications from transvaginal repairs for pelvic organ prolapse (POP) using vaginal mesh have led to a significant decline in its use, despite its initial promise. Following a six-year analysis of California records of pelvic organ prolapse repairs, investigators reporting in The Journal of Urology conclude that use of vaginal mesh may be appropriate in specific cases provided the risk of surgical complications is carefully weighed against the risk of repeat surgery for recurrent prolapse.