An international team of scientists, including researchers at the University of Copenhagen, have identified 62 genes that lead to both higher levels of body fat but a lower risk of cardiovascular and metabolic diseases. These genes may help to keep body fat healthy, and open a new avenue for developing drugs that lower the risk of diabetes and heart disease
Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, including anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties. This study demonstrates that curcumin is a PPARα/γ dual activator and may affect expression levels of proteins involved in amyloid deposition and other metabolism functions in a complex manner.
A study led by IMIM examines whether all so-called good cholesterol (HDL) particles have a cardiovascular protective effect. Traditionally, HDL cholesterol has been associated with a reduced risk of heart disease, but there are doubts as to whether all the particles have a protective effect. The work shows that people with large HDL particles have an increased risk of myocardial infarction, while only small HDL particles are actually associated with decreased risk.
Long thought a vestigial part of human cells, new genetic analysis of the primary cilium shows that it may be tied to common conditions like diabetes and kidney failure
A new study estimates 64% of adult COVID-19 hospitalizations in the U.S. may have been prevented if there were less obesity, hypertension, diabetes, and heart failure. The model suggests notable differences by age and race/ethnicity in COVID-19 hospitalizations related to these conditions.
Genetically determined vitamin D levels do not have a large effect on risk of type 1 diabetes in Europeans, according to a study published 25th February 2021 in the open-access journal PLOS Medicine by Despoina Manousaki from the CHU Sainte Justine and the University of Montreal, Canada and colleagues.
A study aiming to develop a new therapeutic technique could bring a revolution in our approach to treating rare, fatal Sanfilippo syndrome, a disorder that affects children as young as 2 years old and leads to childhood dementia and premature death.
A new study examined the health and economic impacts of mHealth technologies on the outcomes of diabetes patients in Asia. The study concluded that compared to patients who did not use mHealth applications, patients who used the apps had better health outcomes and were able to regulate their health behavior more effectively. They also had fewer hospital visits and lower medical costs.
An international research team, including a biomedical scientist from City University of Hong Kong (CityU), has developed a high-throughput biological assay technique which enabled them to conduct a systematic analysis on the impact of nearly 100,000 genetic variants on the binding of transcription factors to DNA. Their findings provided valuable data for finding key biomarkers of type 2 diabetes for diagnostics and treatments.
According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. These variants have an impact on the expression of genes regulating cholesterol metabolism, among other things. The findings provide valuable new insight into the genetics of coronary artery disease.