The first new national guidelines since 2004 on identifying and treating high blood pressure in children and adolescents (aged 3-18 years old) have been published by the American Academy of Pediatrics (AAP), which convened a panel of experts to produce the new recommendations. The AAP report, offers a series of evidence-based recommendations for pediatricians derived from a comprehensive review of nearly 15,000 medical studies published since 2004.
In striking contrast to the general perception, researchers from the University of Copenhagen have shown in a new study that people with extremely high levels of HDL -- the 'good' cholesterol -- in their blood have a more than 65 percent higher mortality rate than people with normal HDL levels. The researchers say the results should lead to a change in the way 'good' cholesterol is perceived.
A number of factors, including obesity, shorten the lifespan for those with schizophrenia by 20 years and by 10 years for those with bipolar disorder compared to the general population. In the first study to compare long-term weight gain across psychotic disorders, researchers from FAU show that expanding waistlines and the way body fat is distributed are largely to blame.
A new dietary review of 49 observational and controlled studies finds plant-based vegetarian diets, especially vegan diets, are associated with lower levels of total cholesterol, including lower levels of HDL and LDL cholesterol, compared to omnivorous diets. The meta-analysis appears as an online advance in Nutrition Reviews.
An updated analysis of the low-density lipoprotein cholesterol (LDL-C) lowering drugs, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, finds they are not cost-effective at current prices and that even greater price reductions than previously estimated may be needed to meet cost-effectiveness thresholds, according to a study published by JAMA.
The link between a mother's body mass index (BMI) before pregnancy and the metabolic traits of her children is likely mediated by shared genetics and familial lifestyle rather than effects on the fetus during gestation, according to study published this week in PLOS Medicine by Debbie Lawlor of the University of Bristol, UK, and colleagues.
Researchers are exploring a novel approach to treating diabetes: implanting a polymer sponge into fat tissue. Their study has shown that in obese mice with symptoms resembling Type 2 diabetes, the implant reduced weight gain and blood-sugar levels -- by getting the fat to 'talk' again. The researchers are presenting their results at the 254th National Meeting & Exposition of the American Chemical Society.
Researchers from Umeå University in Sweden describe a new method to study biochemical changes that occur in the pancreas during the development of diabetes. The method, recently published in Scientific Reports, is based on molecular spectroscopy and can be used to extract biochemical profiles (or 'fingerprints') containing information about disease progression. The method could facilitate improved understanding of the mechanistic processes on molecular and cellular levels that are key to the development of diabetes.
A re-analysis of all-cause mortality in the United States Preventive Services Task Force (USPSTF) evidence review for colorectal cancer screening found that flexible sigmoidoscopy reduces risk for death. These findings suggest that the USPSTF guidelines for colorectal cancer screening, which concluded that no colorectal cancer screening methods reduced all-cause mortality, could be reassessed.
Scientists of the German Center for Diabetes Research (DZD) in Tübingen discovered that a fatty liver can cause damage to other organs. In two just-published studies they demonstrate the effects of fatty liver disease on the function of the hormone-producing islet cells in the pancreas and on renal function.