A vaccine to immunise people against high levels of cholesterol and the narrowing of the arteries caused by build-up of fatty material (atherosclerosis) may be possible following successful results in mice. Now, a phase I trial in patients has started to see if the findings translate to humans. The study is published in the European Heart Journal.
High blood sugar, also known as hyperglycemia, occurs when the body does not produce enough insulin to turn blood glucose into energy. Although high blood sugar usually only affects diabetics, hyperglycemia has been associated with poorer outcomes for patients undergoing surgical procedures. A recent study by University of Missouri School of Medicine researchers found that following surgery for artery disease of the legs, hyperglycemia can cause complications, increased hospitalizations and mortality for all patients -- even those who are not diabetic.
Gradual accumulation of glycated proteins, lipids and nucleic acid is a common process in normal aging, however rise in blood glucose levels, an increase of oxidative stress over time triggering further protein modification and resulting in impairment of defense mechanisms. AGEs accumulation in various tissues under diabetic conditions plays an important role in the development of neuronal and vascular complications such as diabetic retinopathy.
Researchers have found a new, more accurate way to determine if adolescents are overweight, important findings considering many school districts label adolescents -- who tend to be more vulnerable to weight bias and fat shaming than adults -- as obese.
Engaging in light or moderate physical activity such as taking a walk or going for a bike ride is the best way for normally inactive people to beat the blues and improve their sense of well-being, according to a University of Connecticut study. Researchers say that in this study there was no additional emotional benefit gained from working out aggressively.
A computer-generated physician, now under development at the University of Illinois, explains diabetes and cholesterol test results to would-be patients in videos designed for viewing on electronic medical record portals. The goal of the project is to make electronic medical record portal messages more useful and engaging for patients, particularly older adults with lower levels of health literacy.
Studying how our bodies metabolize lipids such as fatty acids, triglycerides, and cholesterol can teach us about cardiovascular disease, diabetes, and other health problems, as well as reveal basic cellular functions. But the process of studying what happens to lipids after being consumed has been both technologically difficult and expensive to accomplish until now.
A research team, led by South Korea's Ulsan National Institute of Science and Technology (UNIST) has proposed the possibility of in situ human health monitoring simply by wearing a contact lens with built-in wireless smart sensors.
Exosomes isolated from very obese patients behave very differently than those derived from lean patients and may be key players in heightening youths' likelihood of developing atherosclerosis -- which, in turn, places them at higher risk for suffering heart disease and stroke as adults.
A Finnish study coordinated by the Research Centre of Applied and Preventive Cardiovascular Medicine at the University of Turku shows that exposure to cardiovascular risk factors, such as high blood pressure, elevated serum LDL-cholesterol and smoking in childhood and adolescence, is associated with poorer learning ability and memory in middle age.