In this secondary analysis of a randomized clinical trial, researchers examined the association of age with the benefit of intensive treatment to lower lipid levels with a combination therapy of simvastatin and ezetimibe compared to treatment with simvastatin alone after acute coronary syndrome in older patients.
Statins, the most commonly used effective lipid-lowering drugs, are significantly underutilized to treat lipid abnormalities in patients with and at risk for atherosclerotic cardiovascular disease (ASCVD), according to a retrospective study of more than 280,000 patients in Alberta, Canada. Investigators report in the Canadian Journal of Cardiology that only two-thirds of these patients were receiving moderate/high-intensity statins, and of the ones treated, more than a third are under-treated.
Researchers have developed a significantly improved delivery mechanism for the CRISPR/Cas9 gene editing method in the liver. The delivery uses biodegradable synthetic lipid nanoparticles that carry the molecular editing tools into the cell to precisely alter the cells' genetic code with as much as 90% efficiency. The nanoparticles could help overcome technical hurdles to enable gene editing in a broad range of clinical therapeutic applications.
In adults already at a healthy weight or carrying just a few extra pounds, cutting around 300 calories a day significantly improved already good levels of cholesterol, blood pressure, blood sugar and other markers.
A new study by Massachusetts General Hospital shows that labeling food choices in a hospital cafeteria with simple 'traffic-light' symbols indicating their relative health value was associated with a reduction in calories purchased by employees.
There is only one cardiac rehab spot for every 12 of those patients to prevent another heart event, according to new research from York University. A global audit and survey of cardiac rehab conducted in York University's Faculty of Health showed that cardiac rehab is available in only half of the world's countries, and the programs that do exist can only serve 1.65 million patients, leaving a gap of over 18 million patients in need.
A small chemical change -- shifting the position of two hydrogen atoms -- makes the difference between mice that are healthy or that have insulin resistance and fatty liver, major risk factors for diabetes and heart disease. Making the change prevented the onset of these symptoms in mice fed a high-fat diet and reversed these prediabetes obese mice. Published in Science, the finding pinpoints a 'druggable' target that could be used to develop therapies for diabetes.
A pressing question in diabetes research is how elevated blood levels of sugar, cholesterol, and fat may contribute to blood vessel damage in relation to the diet. A new study by investigators from Brigham and Women's Hospital set out to determine which components of the Western diet -- one rich in sugar, cholesterol and fat -- may worsen diabetes complications.
Overweight, diabetes, heart disease, and many forms of cancer are driven by unhealthful diets, but most doctors do not have the knowledge to turn this problem around.
Current guidelines recommend lowering cholesterol for heart disease risk reduction. New findings indicate that if cholesterol dips too low, it may boost the risk of hemorrhagic stroke, according to researchers.