People who sleep less than six hours a night may be at increased risk of cardiovascular disease compared with those who sleep between seven and eight hours, suggests a new study published in the Journal of the American College of Cardiology. Poor quality sleep increases the risk of atherosclerosis -- plaque buildup in the arteries throughout the body -- according to the study.
In a paper to be published in the September/December 2019 issue of TECHNOLOGY, a team of researchers from the IIT, Chicago, has developed a novel microfluidic device for measuring in real-time the cholesterol secreted from liver tissue-chip containing human hepatocytes. This innovation can help researchers employing microfluidic cultures to study the effects of drugs such as statins on lowering cholesterol in real-time.
High LDL a leading risk factor for heart disease. Many cholesterol medications lower LDL, some of them by targeting the protein PCSK9. In the January issue of the Journal of Lipid Research, scientists at the University of California, San Francisco, report on an investigation into why experiments on PCSK9 give different results in a test tube and in liver cells. What they found may explain how a mutation in PCSK9 that has long puzzled scientists leads to heart disease.
Compared with a glucagon-line peptide-1 (GLP-1) agonist, canagliflozin was not associated with an increased risk for fracture in patients with type 2 diabetes at relatively low risk for fracture. Findings from a multidatabase cohort study are published in Annals of Internal Medicine.
Large quantities of rich Christmas food appear to boost Danes' cholesterol levels. Right after the Christmas break, levels are 20 percent higher than in the summer. So says a new study carried out by researchers from the Department of Clinical Biochemistry at Copenhagen University Hospital and the Department of Clinical Medicine, University of Copenhagen.
ETH Zurich scientists have shown that statins, one of the most commonly prescribed classes of pharmaceuticals, reduce beneficial brown adipose tissue. But this is no reason to demonize these drugs, the researchers insist.
For those who have already had a heart attack or a stroke, the combination of statins and Mediterranean Diet appears to be the most effective choice to reduce the risk of mortality, especially from cardiovascular causes. It is the result of an Italian study conducted at the I.R.C.C.S. Neuromed, Pozzilli, Italy on over 1,000 adults recruited in the Moli-sani Study, published in the International Journal of Cardiology.
Excessive dietary cholesterol (and its uptake) can cause hypercholesterolemia. In a new paper, researchers show that intestinal cholesterol absorption requires the complex lipid GM3. Disrupting GM3 synthesis can reduce the incidence of high cholesterol in mice fed a high-cholesterol diet, suggesting the pathway as a lipid-lowering drug target.
A new study by USC scientists provides new insight on how dietary fat and cholesterol drive the development of non-alcoholic steatohepatitis (NASH), a serious form of non-alcoholic fatty liver disease
The holiday season is a hard one for anyone watching their weight. The sights and smells of food are hard to resist. One factor in this hunger response is a hormone found in the stomach that makes us more vulnerable to tasty food smells, encouraging overeating and obesity.