Diabetes is associated with various health problems including decline in skeletal muscle mass. A Japanese research group revealed that elevation of blood sugar levels leads to muscle atrophy and that two proteins play key roles in this phenomenon. These findings were published on Feb. 21 in the online edition of JCI Insight.
People with diabetes have a 35 percent higher risk of experiencing low back pain and 24 percent higher risk of having neck pain than those without diabetes, a review by University of Sydney researchers has found.
A UC San Francisco study of human and mouse pancreatic tissue suggests a new origin story for type 1 (T1) diabetes. The findings flip current assumptions about the causes of the disease on their head and demonstrate a promising new preventative strategy that dramatically reduced disease risk in laboratory animals.
A pair of Affordable Care Act clauses had a sizable effect on the ability of people with diabetes to get health insurance, a new study suggests. Before the requirements took effect, the percentage of people with private health insurance who had diabetes had declined, but it began to increase again after the ACA required insurers to accept people with pre-existing conditions, and limited their ability to charge higher rates to older people.
Hypertension is an important public health problem that can lead to life-threatening cardiovascular events, including heart attack and stroke. Here, the relationship between dietary intake of n-6 fatty acids and hypertension, using blood pressure measurement and a diet history questionnaire. A Kanazawa University research team found that increased dietary intake of n-6 fatty acids positively impacted hypertension, but that this benefit was limited to individuals without impaired glucose tolerance.
Scientists from the Diabetes Research Institute at the University of Miami have engineered a human pluripotent stem cell line containing two 'suicide genes' that induce cell death in all but the desired insulin-producing cells. This double fail-safe approach addresses the limitations of pluripotent stem cell-derived beta cells and opens the door to creating safe cell-replacement therapies for people living with type 1 diabetes.
Cholesterol-lowering statin drugs reduce the risk of cardiovascular disease in kidney disease patients who are not on dialysis. But a new study finds that statins are used by only 21.8 percent of such patients who do not already have cardiovascular disease or diabetes or have not been diagnosed with high cholesterol.
A high-protein, low-calorie diet helps older adults with obesity lose more weight, maintain more muscle mass, improve bone quality and lose 'bad' fat, according to results from a new randomized controlled trial led by Wake Forest University researcher Kristen Beavers.
For the first time, researchers have shown that ordinary human cells can change their original function. This may give new hope for type 1 diabetes patients.
Biology textbooks teach us that adult cell types remain fixed in the identity they have acquired upon differentiation. By inducing non-insulin-producing human pancreatic cells to modify their function to produce insulin in a sustainable way, researchers at the University of Geneva, Switzerland, show for the first time that the adaptive capacity of our cells is much greater than previously thought. Moreover, this plasticity would not be exclusive to human pancreatic cells.