Researchers have mapped the molecular structure and dynamics of an aggressive protein modification that spurs on Alzheimer's disease. A new study in the Proceedings of the National Academy of Sciences offers greater understanding of the microscopic, toxic protein fragments, called beta amyloids (Aβ), that cause rapid acceleration of Alzheimer's disease.
Older adults who regularly take part in word and number puzzles have sharper brains, according to the largest online study to date.
Researchers at The University of Chicago have demonstrated that the type of bacteria living in the gut can influence the development of Alzheimer's disease symptoms in mice. The study, which will be published May 16, 2019 in the Journal of Experimental Medicine, shows that, by altering the gut microbiome, long-term antibiotic treatment reduces inflammation and slows the growth of amyloid plaques in the brains of male mice, though the same treatment has no effect on female animals.
Magnetic stimulation of the brain improves working memory, offering a new potential avenue of therapy for individuals living with Alzheimer's disease and other forms of dementia, according to new research from the Duke University School of Medicine.
As spring arrives in the northern hemisphere, many people are cursing ragweed, a primary culprit in seasonal allergies. But scientists might have discovered a promising new use for some substances produced by the pesky weed. In ACS' Journal of Natural Products, researchers have identified and characterized ragweed compounds that could help nerve cells survive in the presence of Alzheimer's disease (AD) peptides.
Researchers at UC Davis and UC San Francisco have found a way to teach a computer to precisely detect one of the hallmarks of Alzheimer's disease in human brain tissue, delivering a proof of concept for a machine-learning approach to distinguishing critical markers of the disease.
A jawless parasitic fish could help lead the way to more effective treatments for multiple brain ailments, including cancer, trauma and stroke. A team of biomedical engineers and clinician-scientists at the University of Wisconsin-Madison and the University of Texas at Austin borrowed molecules from the immune system of the parasitic sea lamprey to deliver anti-cancer drugs directly to brain tumors.
Many Americans in their 50s and early 60s are worried about declining brain health, especially if they have loved ones with memory loss and dementia, a new national poll finds. But while the majority of those polled say they take supplements or do puzzles in an effort to stave off brain decline, very few of them have talked with their doctors about evidence-based ways to prevent memory loss.
Abnormal accumulations of amyloid plaques and tau neurofibrillary tangles are both needed to drive the death of brain cells, or neurons. But scientists still have a lot to learn about how amyloid impacts tau to promote widespread neurotoxicity, which destroys cognitive abilities like thinking, remembering and reasoning in patients with Alzheimer's. While investigating the molecular relationship between amyloid and tau, University of South Florida neuroscientists discovered that the Aβ-activated enzyme cofilin plays an essential intermediary role in worsening tau pathology.
Rewards are necessary for learning, but may actually mask true knowledge, finds a new Johns Hopkins University study with rodents and ferrets. The findings, published May 14, 2019 in Nature Communications, show a distinction between knowledge and performance, and provide insight into how environment can affect the two.