Few studies have examined how the neighborhood's physical environment relates to cognition in older adults. Researchers categorized 4,716 individuals by apolipoprotein E (APOE) genotype -- a genetic risk factor for Alzheimer's disease (AD) to determine if there are cognitive benefits of living in neighborhoods with greater access to social, walking and retail destinations. Results showed that the positive influence of neighborhood environments on cognition are strongest among those who are at the lowest risk for AD, specifically APOE ε2 carriers.
As out-of-pocket costs go up for drugs for the neurologic disorders Alzheimer's disease, peripheral neuropathy and Parkinson's disease, people are less likely to take the drugs as often as their doctors prescribed, according to a study funded by the American Academy of Neurology and published in the Feb. 19, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Harvard researchers have discovered a new mechanism for how the brain and its arteries communicate to supply blood to areas of heightened neural activity. The findings enable new avenues of study into the role of this process in neurological diseases.
Today, at a European Parliament lunch debate, Alzheimer Europe launched a new report presenting the findings of its collaborative analysis of recent prevalence studies and setting out updated prevalence rates for dementia in Europe. The report findings show that, despite a marked reduction in the prevalence of dementia, the number of people with dementia is nonetheless set to double by 2050.
The protein β-arrestin-2 increases the accumulation of brain-damaging tau tangles, a cause several forms of dementia, by interfering with removal of excess tau from the brain, a new study by the University of South Florida Health (USF Health) Morsani College of Medicine found. The research suggests a new treatment approach that could be preventive for those at risk or with mild cognitive impairment, and also for those with Alzheimer's disease and other overt dementias caused by tau.
Researchers in Japan have identified a new quality control system that allows cells to remove damaged and potentially toxic proteins from their surroundings. The study, which will be published Feb. 18, 2020 in the Journal of Cell Biology, finds that the Clusterin protein and heparan sulfate proteoglycans combine to bring misfolded proteins into cells for degradation. The findings may lead to new therapeutic targets for neurodegenerative disorders, including Alzheimer's disease.
Researchers at UC San Diego School of Medicine report that abnormal levels of beta-amyloid plaques in brain predict cognitive decline and higher risk of developing Alzheimer's disease, but also that cognitive performance predicts progression from normal to abnormal levels of beta-amyloid.
In a study published in Annals of Clinical and Translational Neurology, a team led by investigators from Brigham and Women's Hospital describes the role of plasma ceramides in dementia and Alzheimer's disease (AD) and their potential as a blood-based biomarker.
A study by York University psychology researchers provides new evidence that bilingualism can delay symptoms of dementia. Researchers found bilingualism provides the brain with greater cognitive reserve, delaying onset of symptoms.
Astrocytes are neural cells with many important functions in the nervous system. The inflammation of these cells occurs in brain infections and neurodegenerative disorders, a process called astrogliosis. Aware of this fundamental process for the prevention of diseases and improvement of current treatments, a team led by researchers at the D'Or Institute for Research and Education (IDOR) and other five Brazilian Federal Universities published one of the first studies to categorically observe this inflammatory reaction in human astrocytes created in the laboratory.