In the cover article in the current issue of Cell, BU Biomedical Engineer Ahmad S. Khalil along with colleagues from MIT and the Whitehead Institute for Biomedical Research, among others, describe the synthetic genetic tool they built to quantitatively sense, measure and manipulate protein aggregation in live cells. This may open the door to greater understanding and treatment of a range of maladies from Alzheimer's to type II diabetes.
A delayed neurological response to processing the written word could be an indicator that a patient with mild memory problems is at an increased risk of developing Alzheimer's disease, research led by the University of Birmingham has discovered.
A metallic probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide has identified a binding site that could facilitate better drugs to treat Alzheimer's disease. When the probe is illuminated, it catalyzes oxidation of the protein in a way that might keep it from aggregating in the brains of patients.
Glucose levels are reduced in the brains of individuals with obesity and type 2 diabetes compared to lean individuals, according to a new Yale study. The finding might explain disordered eating behavior -- and even a higher risk of Alzheimer's disease -- among obese and diabetic individuals, the researchers said.
a new study published online this week in the American Journal of Human Genetics from Penn researchers helps answer that question by uncovering the mechanisms of the genetic mutations, or variants, associated with the gene.
Scientists at the Massachusetts General Hospital, in collaboration with colleagues at the University California, San Diego, have characterized a new class of drugs as potential therapeutics for Alzheimer's disease and discovered a piece in the puzzle of how they would work.
Health professionals can deliver quality neurological care remotely to patients through the emerging field of teleneurology. However, medical training has not caught up with the field, and a lack of formalized education for teleneurology doesn't exist. Now, a researcher at the University of Missouri School of Medicine, as part of an American Academy of Neurology (AAN) team, has developed a standardized curriculum for providing remote neurology care via telecommunication.
A new imaging system that offers a better way to monitor the brain changes indicative of Alzheimer's in mouse models of the disease could help speed new drug development.
University of Iowa researchers report that a roundworm can learn to put on alert a defense system important for protecting cells from damage. The finding could lead to a new approach for treating neurodegenerative diseases in humans caused by damaged cells.
A team of researchers reveals a mechanism that can explain how even relatively infrequent seizures can lead to long-lasting cognitive deficits in animal models.