The ability to generate spoken verbs in infinitive in a given time begins to worsen in the early stages of Alzheimer's disease (AD). Thus, the verb fluency test has been found to be a suitable neuropsychological tool for the detection of healthy aging people at risk of developing cognitive impairment, according to a recent research of the Research Center and Memory Clinic. Fundació ACE. Institut Català de Neurociències Aplicades, UIC-Barcelona, Spain.
A research conducted by the UAB demonstrates that mice suffering from this disease also have substantial malfunctions in small blood vessels, important in nourishing different organs and tissues and in regulating blood pressure, and which mainly affects females. The study also demonstrates a correlation between the state of peripheral blood vessels and different levels of anxious behaviour, both in normal ageing and in those suffering from Alzheimer's disease.
A new, biocompatible photooxygenation catalyst that can selectively oxygenate and degrade the pathogenic aggregation of Alzheimer's disease (AD)-related amyloid-β peptide (Aβ) under near-infrared (NIR) light irradiation is developed. The catalyst was able to oxygenate Aβ embedded under the skin of a living mouse, and diminished intact Aβ level in AD-model mouse brain. The new catalyst is potentially applicable for the treatment of peripheral amyloid diseases and AD.
While there has been an increased focus on person-centered models of care transition for cognitively intact older adults from hospital to home, little is known about the core elements of successful transitions in care specifically for persons with dementia.
Inhibitory interneurons are particularly important for managing brain rhythms. They're also the research focus of a laboratory led by Jorge Palop, Ph.D., assistant investigator at the Gladstone Institutes. In a study published in Neuron, Palop and his collaborators uncovered the therapeutic benefits of genetically improving these interneurons and transplanting them into the brain of a mouse model of Alzheimer's disease.
A Spectrum Health study has found that dementia patients are not undergoing evaluation at the onset of the dementia process, a delay that prevents early, beneficial treatment. Researchers retrospectively reviewed 110 randomly chosen initial evaluations from the Spectrum Health Medical Group Neurocognitive Clinic. They found that 78.9 percent of the patients evaluated already had moderate or severe dementia at the time of diagnosis. The study suggests that home-based, patient-centered care may improve early screening and detection.
Salk scientists create new molecular scissors to correct protein imbalance in cellular model of dementia.
Scientists at the Allen Institute and the University of Washington have developed a new low-cost technique for profiling gene expression in hundreds of thousands of cells.
Researchers at the German Center for Neurodegenerative Disease (DZNE) have found a possible explanation for the difficulty in spatial orientation experienced sometimes by elderly people. In the brains of older adults, they detected an unstable activity in an area that is central for spatial navigation. The results are reported in the journal Current Biology. In the long term, these findings might open up new ways for detecting Alzheimer's disease.
Salk scientists discover that brain storage capacity is dynamic and varies by region.