Recent articles in the journal Molecular & Cellular Proteomics investigate metabolic quirks of cancer cells, the effects of inhibiting the enzyme that generates amyloid beta, and the mechanism by which a bacterial toxin kills host cells.
Memorization test and non linear EEG analysis could be helpful in identifying subjects at high risk of dementia at the very early stages of cognitive impairment.
A new machine-learning model that scans routinely collected NHS data has shown promising signs of being able to predict undiagnosed dementia in primary care, according to research by the University of Plymouth. The results from the feasibility study suggest that the model could significantly reduce the number of those living with undiagnosed dementia.
A woman's history of pregnancy may affect her risk of Alzheimer's disease decades later, according to a study published in the July 18, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A Johns Hopkins Medicine analysis of information gathered for an ongoing and federally sponsored study of aging and disability adds to evidence that a substantial majority of older adults with probable dementia in the United States have never been professionally diagnosed or are unaware they have been.
One major problem with understanding Alzheimer's is not being able to clearly see why the disease starts. A super-resolution 'nanoscope' developed by Purdue University researchers now provides a 3D view of brain molecules with 10 times greater detail. This imaging technique could help reveal how the disease progresses and where new treatments could intervene.
Yale researchers have tested a new method for directly measuring synaptic loss in individuals with Alzheimer's disease. The method, which uses PET imaging technology to scan for a specific protein in the brain linked to synapses, has the potential to accelerate research for new Alzheimer's treatments, the researchers said.
Researchers at the UT Southwestern Medical Center have uncovered details of how cells invite inside corrupted proteins that can turn normal proteins corrupt, leading to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Understanding the molecular details of how these proteins spread from cell to cell could lead to therapies to halt disease progression.
Arranging into well-organized fibrillar aggregate, commonly known as amyloid fibril is an inherent property of any polypeptide chain. Amyloid fibrils are associated with a number of severe human pathologies like the Alzheimer's disease, Parkinson's disease, type 2 diabetes and many more. This review article includes the recent studies of identification and characterization of possible conformations of proteins which can act as aggregation precursor state (APS).
The ability to obtain new memories in adulthood may depend on neurogenesis -- the generation of new neurons in the hippocampus -- to clear out old memories that have been safely stored in the cortex, according to research in male rats published in JNeurosci.