The first human study to look at how blood proteins vary over a 24-hour-period identified 30 with distinct time-of-day patterns and more than 100 that are disrupted by simulated night shift work
Disruption to normal daily circadian rhythms is associated with a greater susceptibility to mood disorders such as severe depression and bipolar disorder over the life course, according to the largest observational study of its kind involving over 91,000 people, published in The Lancet Psychiatry.
A mouse study published in JNeurosci finds that restricting food availability to one half of the day resets the normal timing of the signals that regulate food intake and reduces weight gain in mice fed a high-fat diet.These findings could inform future obesity research in humans.
For years, doctors have associated the BRCA1 and BRCA2 gene mutations with an increased risk of breast cancer. But researchers at Texas A&M University have now identified another gene that may have an impact on breast cancer --associated with the body's circadian rhythm.
Night shifts have an impact on genes regulating important biological processes and their expression can't adapt to new sleeping and eating patterns and that most of them stay tuned to their daytime biological clock rhythms.
For the first time, the lab of Nobel laureate Aziz Sancar measured DNA repair after cisplatin treatment throughout the entire genome of a mammal over the 24-hour circadian cycle. They found DNA repair of normal tissue was most robust predawn and pre-dusk in mice, and these could represent the best times for treatment using the anti-cancer drug cisplatin, though much more work needs to be done.
A research team including a researcher from the Faculty of Health and Medical Sciences has discovered a circuit in the brains of mice connecting circadian rhythm to aggressive behaviour. The discovery is particularly interesting to Alzheimer's patients who experience increased aggression at night. The researchers have developed special protein tools capable of turning off the cells in the brain causing the behaviour.
New research published in The Journal of Physiology has illuminated the effects of night-time light exposure on internal body clock processes. This is important for helping those who have poor quality sleep, such as shift workers, and could help improve treatments for depression.
A study published in Environmental Health Perspectives reports a link between exposure to blue light at night and higher risk of developing breast and prostate cancer. Blue light is a range of the visible light spectrum emitted by most white LEDs and many tablet and phone screens.
Using drug repurposing, a team of researchers led by animal biologists at Nagoya University has discovered compounds that can either shorten or lengthen the circadian rhythm in human cells. A hormone, also known as a common anti-aging supplement demonstrated period-shortening activities, and when it was fed to mice, jet lag symptoms were significantly reduced.