A new study shows that a synthetic molecule developed by Oregon Health & Science University scientists stimulates repair of the protective sheath that covers nerve cells in the brain and spinal cord. The study demonstrates in mice that a synthetic molecule called sobetirome efficiently repairs damaged myelin without side effects.
Human perception is based on mathematically optimal principles, but the brain implements those principles imperfectly, suggests new research by Elina Stengård and Ronald van den Berg of the University of Uppsala, Sweden. They present their findings in PLOS Computational Biology.
Circulation and cellular activity were restored in a pig's brain four hours after its death, a finding that challenges long-held assumptions about the timing and irreversible nature of the cessation of some brain functions after death, Yale scientists report April 18 in the journal Nature.
Researchers have developed a high-tech support system that can keep a large mammalian brain from rapidly decomposing in the hours after death, enabling study of certain molecular and cellular functions. With funding through the NIH BRAIN Initiative, researchers developed a way to deliver an artificial blood supply to the isolated postmortem brain of a pig, preventing the degradation that would otherwise destroy many cellular and molecular functions and render it unsuitable for study.
Investigators from Brigham and Women's Hospital, in collaboration with colleagues at King's College London and INSERM-Paris, have discovered a fundamentally new way to measure brain function using a technology known as magnetic resonance elastography (MRE), an approach that creates maps of tissue stiffness using an MRI scanner.
Researchers in Colorado examined medical records of 250 patients who received endoscopic procedures after 2012, when the state legalized recreational cannabis. They found patients who smoked or ingested cannabis on a daily or weekly basis required 14% more fentanyl, 20% more midazolam, and 220% more propofol to achieve optimum sedation for routine procedures, including colonoscopy.
Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice. Ketamine treatment restored lost dendritic spines and rescued coordinated neural activity in the Prefrontal Cortex of the mice -- findings that may help researchers develop interventions that promote lasting remission of depression in humans. The study was funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health.
A newly published paper in the Lancet journal EBioMedicine identifies a link between high levels of blood lipids and worsening of disease in multiple sclerosis (MS) patients who are overweight or obese.
Scientists have revealed the structure of a critical receptor in the brain associated with learning, memory, behavior and mood. The new research, published in the journal Science, is the first to reveal the structure of AMPA receptors in their natural state. This discovery could lead to new insight about the mechanism behind a wide range of nervous system disorders and diseases.
Delving deep inside the neural circuitry of 'depressed' mice, researchers have revealed how ketamine works in cells to achieve its fast-acting antidepressant effect.