A natural immune system response may be responsible for inflicting additional harm in the weeks and months after a spinal injury.
Genetic variants damaging neurotransmitter receptor implicated in development of schizophrenia. Genetic variants which prevent a neurotransmitter receptor from working properly have been implicated in the development of schizophrenia, according to research by the UCL Genetics Institute.
Fluorescent tagging of cellular proteins has allowed unprecedentedly detailed images of brain circuits, but imaging neurons and synapses over large areas in fine detail is difficult. Researchers at HHMI, UC Berkeley and MIT have joined two techniques -- expansion microscopy and lattice light-sheet microscopy -- to capture neural circuits, including all synapses, in a whole fly brain in only three days, versus up to 10 years for EM whole-brain imaging. This allows rapid study of brain circuits.
Defects in the transport of cells' energy organelles are a suspected cause of diseases including Alzheimer's, ALS, Huntington's and Parkinson's. A new study reveals the genetics behind mitochondrial shifts.
A special issue of Viral Immunology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, contains a rich collection of the latest research and reviews focusing on Viral Neuroimmunology and the intricacies of viral brain infection.
Those who regulate their brain rhythm themselves can release capacities to learn new things.
A study finds a surprising response to cocaine in a novel strain of mutant mice -- they failed to show hyperactivity seen in normal mice when given cocaine and didn't run around. In other tests, they still found cocaine appealing, but displayed an inability to shake the memory of cocaine's actions when the drug was no longer administered. The key change that blocks cocaine's stimulant effects in these mice is serotonin, not dopamine, which is responsible for producing a high.
Multiple sclerosis is a demyelinating inflammatory disorder in which autoreactive T cells migrate into the central nervous tissue and damage oligodendrocytes and myelin, which protect nerve cells. Sephin1 prolongs a cytoprotective response in oligodendrocytes, protecting those cells and myelin from this inflammatory attack. It dampens central nervous system inflammation, limits myelin damage and reduces the reactivation of T cells
Researchers at the University of Zurich have determined the three-dimensional structure of the receptor that causes nausea and vomiting as a result of cancer chemotherapy. The study explains for the first time why some drugs work particularly well in ameliorating these side effects. The results also provide important insights into how to develop compounds to effectively tackle other disorders.
Now new data by UTSA shows how the release of the neurotransmitter dopamine changes when working for cocaine. Our brains naturally release dopamine to reward us for working hard for something gratifying, for example, enjoying a sweet piece of chocolate. Yet when it comes to illicit substances such as cocaine, the harder the effort put into getting cocaine, the less likely there will be a large jolt of dopamine.