Working with colleagues from Harvard Medical School and Würzburg, researchers from Charité - Universitätsmedizin Berlin have been examining the use of deep brain stimulation in the treatment of Parkison's disease in an attempt to optimize treatment effectiveness. The results, describing an effective network profile of deep brain stimulation has been reported in the journal Annals of Neurology*.
Exosomes - tiny biological nanoparticles which transfer information between cells - offer significant potential in detecting and treating disease, the most comprehensive overview so far of research in the field has concluded. Areas which could benefit include cancer treatment and regenerative medicine.
Researchers from ITMO University have built a setup for recording holograms of tiny objects like living cells with a femtosecond speed. The new method allows one to reconstruct phase topography of a studied sample according to deformations that emerge in a laser pulse when it passes through the specimen. In comparison to electron microscopes, the device can visualize transparent biological structures without introducing contrast agents. The paper was published in Applied Physics Letters.
Parkinson's disease is commonly thought of as a movement disorder, but after years of living with the disease, approximately 25 percent of patients also experience deficits in cognition that impair function. A newly developed research tool may help predict a patient's risk for developing dementia and could enable clinical trials aimed at finding treatments to prevent the cognitive effects of the disease.
Researchers have found the first direct evidence that autoimmunity plays a role in Parkinson's disease, suggesting that immunosuppressants might play a role in treatment.
After years of living with Parkinson's Disease approximately 25% of patients experience deficits in cognition that impair function. A new research tool may help predict a patient's risk for developing dementia and could enable clinical trials aimed at finding treatments to prevent the cognitive effects of the disease.
The researchers hypothesized that older participants would not be able to maintain an increase in speed and amplitude of movement over time due to fatigue, but were surprised to discover that making mistakes helped improve future task performance. They also found that once a better movement pattern was established, the variability dropped. Making exaggerated movements actually helped them fine-tune their control.
A new, high-resolution view of the structure of Hsp104 (heat shock protein 104), a natural yeast protein nanomachine with six subunits, may show news ways to dismantle harmful protein clumps in disease.
Duke University researchers have identified a potential new mechanism in both mice and human endocrine cells that populate the small intestines. Inside these cells is a protein called alpha-synuclein, which is known to go awry and lead to damaging clumps in the brains of Parkinson's patients, as well as those with Alzheimer's disease.
Use of statins may speed up the onset of Parkinson's disease symptoms in people who are susceptible to the disease, according to Penn State College of Medicine researchers.