The mechanism our immune cells use to clear bacterial infections like tuberculosis (TB) might also be implicated in Parkinson's disease, according to a new study. The findings provide a possible explanation of the cause of Parkinson's disease and suggest that drugs designed to treat Parkinson's might work for TB too.
In a world first, clinicians have reduced 'freezing of gait' in Parkinson's disease patients by teaching brain training exercises in a randomized control trial led by Brain and Mind Centre scholars at the University of Sydney and published today in npj Parkinson's Disease.
New research in mice reveals how specialized neurons allow the brain to construct sequences of movements. Damage to these neurons disrupts the ability to correctly string together movements into desired actions. The findings may inform the study and eventual treatment of movement disorders such as Parkinson's and Huntington's.
A UC San Diego-led team has identified a gene that helps prevent the harmful buildup of proteins that can lead to neurological disorders such as Alzheimer's and Parkinson's disease. As published in Nature, the researchers found that the 'Ankrd16' gene acts like a failsafe in proofreading and correcting errors to avoid the abnormal production of improper proteins.
In research that could lead to future therapies for age-related diseases, Brown University researchers have found a new way to stimulate the process by which cells recycle their spare parts.
A new tool developed by researchers at the National Institutes of Health has determined, for the first time, how two distinct sets of neurons in the mouse brain work together to control movement.
An article published in Nature Medicine shows that the inheritance of small changes in DNA alters the expression of the PM20D1 gene and is associated with an increased risk of developing Alzheimer's disease.
Human steps are associated with neural activity that alternates between the left and right sides of the brain, finds a study of Parkinson's disease patients published in JNeurosci. The research recommends future investigations address whether alternating deep brain stimulation accordingly may improve gait in movement disorders.
In Parkinson's disease and dementia with Lewy bodies, pathological aggregates of misfolded alpha-synuclein protein develop in brain neurons. Researchers have now described changes in hippocampal neurons early after the aggregates begin to appear. This understanding, combined with further exploration of the mechanisms underlying the neuronal changes, could point to novel therapeutic treatments to prevent or reverse neuronal defects and halt development of dementia.
SERCA activator may improve memory and cognition for Alzheimer's patients by preserving calcium ion balance in neurons and offering a new therapeutic strategy for neurodegeneration drug development. A report on this study was published in the Bioorganic & Medicinal Chemistry Letters.