The vessels appear to carry previously unknown messages from the brain to the immune system that ultimately cause the disease symptoms. Blocking those messages may offer doctors a new way to treat a potentially devastating condition that affects more than 2 million people.
Astrocytes important role in brain function suggests they are also involved in disease. Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified an astrocyte subpopulation as the dominant cell type to spring into action in vivo (in a living organism) in a neuroinflammatory disease setting. Their early activation inspired their new name: ieAstrocytes (immediate early astrocytes). The study published today in eNeuro.
In a new study published in the scientific journal of repute Nature Communications researchers from the University of Copenhagen have discovered how an enzyme that plays a key role in cancer development functions. The researchers hope the new knowledge will lead to the design of more precise drugs.
MIT neuroscientists devised a way to measure dopamine in the brain for up to a year, which they believe will teach them much more about its role in key brain functions and in disorders such as depression and Parkinson's disease.
Researchers at University of Utah Health found that ADHD patients had an increased risk of developing Parkinson's and Parkinson-like diseases than individuals with no ADHD history.
Deaths associated with Parkinson's disease and related disorders increased substantially between 2001 and 2014. Parkinson's disease was in fact the most common cause of death associated with a neurological condition, according to a report by Public Health England. International experts reporting in the Journal of Parkinson's Disease evaluate these findings and address important implications for future healthcare needs.
Parkinson's disease is the most common neurodegenerative diseases; currently there is no cure. Aggregation of the protein α-synuclein plays a key role in this disease. Together with a US drug company, Researchers from Aarhus University have now carried out a new screening strategy which has identified novel and structurally diverse aggregation inhibitors.
Small, New World monkeys called marmosets can mimic the sleep disturbances, changes in circadian rhythm, and cognitive impairment people with Parkinson's disease develop, according to a new study by scientists at Texas Biomedical Research Institute.
New work from researchers at Columbia University Vagelos College of Physicians and Surgeons sheds light on how dopamine receptors signal within cells, opening the door for more targeted -- and more tolerable -- therapeutics to treat an array of neuropsychiatric disorders.
Researchers have modified the protein Nurr1 so that it can enter cells from the outside. Even though Nurr1 has been discussed as a potential target for the treatment of Parkinson's disease, it is unusable in its normal form, as it cannot penetrate cells. The team deployed a bacterial import signal in order to deliver Nurr1 into cells. The researchers also demonstrated that the modified protein may have a positive effect on the survival of dopamine-producing nerve cells.