5-hydroxytryptamine subtype 6 receptor (5-HT6R) has been extensively considered as a promising therapeutic target for the treatment of neuropathological disorders. 5-HT6R were hypothesized to be implicated in the processes of learning, memory retention, and cognition. Several selective 5-HT6R ligands are currently undergoing clinical trials for treatment of Alzheimer's disease and schizophrenia, SB-742457 and Lu-AE-58054.
Screen time before bed can mess with your sleep. But people without TV and laptops skimp on sleep too, researchers say. A Duke University study of people living without electricity or artificial light in a remote farming village in Madagascar finds they get shorter, poorer sleep than people in the US or Europe. But they seem to make up for lost shuteye with a more regular sleep routine, the researchers report.
Toyohashi University of Technology, in collaboration with the National Institute of Advanced Industrial Science and Technology and Asahi Kasei Homes, conducted research on the influence of airflow from the air conditioner on sleep. Using an air conditioner helps people sleep better on sweltering nights. However, researchers found that when airflow is directed at a human body, even at an insensible velocity, it impacts on sleep conditions causing sleeping positions and affects the depth of sleep.
Clinical decision-making is a complex process, driven by multiple factors, including social and psychological dynamics, peer pressure and even exposure to drug advertising. Now research from Harvard Medical School shows that when it comes to a physician's choice of insomnia medication, habit may trump all else.
A new clinical practice guideline is the first from the American Academy of Sleep Medicine to provide comprehensive, evidence-based analyses of individual agents commonly used in the treatment of chronic insomnia disorder.
A new study suggests that the melatonin content of dietary supplements often varies widely from what is listed on the label.
Probiotics are well known to benefit digestive health, but prebiotics are less well understood. Recent study in rats shows that prebiotic fibers may help to protect beneficial gut bacteria and restore healthy sleep patterns after a stressful event.
Massachusetts General Hospital investigators have developed a novel approach to analyze brainwaves during sleep, which promises to give a more detailed and accurate depiction of neurophysiological changes than provided by a traditional sleep study.
A conducted in mice reveals that sleep may be regulated in part by several brain-based immune proteins collectively called inflammasome NLRP3.
In our modern times, many of us sit up late into the night, watching TV, fiddling with our smartphones, or reading a book by lamplight. Getting up to the sound of the morning alarm isn't easy. Now, researchers reporting in Current Biology on Feb. 2 have more evidence to suggest that the solution to these sleeping woes could be as simple as spending more time outdoors in the sun.