In the largest study of its kind, researchers from the Musculoskeletal Research Unit at the University of Bristol have identified the most important risk factors for developing severe infection after knee replacement. Patients who are under 60 years of age, males, those with chronic pulmonary disease, diabetes, liver disease, and a higher body mass index are at increased risk of having the joint replacement redone (known as revision) due to infection.
Scientists from Sanford Burnham Prebys have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate -- an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline. The study was published in Nature Communications.
In the first North American stem cell clinical trial for osteoarthritis of the knee patients, 12 patients were given injections of their own stem cells and followed for 12 months. The results show a significant improvement in pain levels and quality of life.
Researchers have developed a technique to improve the characteristics of engineered tissues by using ultrasound to align living cells during the biofabrication process.
In a new study conducted in rats, researchers found a four-week period of rest was nearly as effective as an experimental drug at reducing discomfort and regaining function after an injury from repeated moderate-strain activity. The findings are relevant to treating common musculoskeletal disorders caused by overuse, such as carpal tunnel syndrome, tendinitis, tendinosis and low back pain.
Some studies have suggested that minerals such as zinc and iron may play a role in how multiple sclerosis (MS) progresses, once people have been diagnosed with it. But little was known about whether zinc, iron and other minerals play a role in the development of the disease. A new study shows no link between dietary intake of several minerals and whether people later develop MS.
The April issue of Neurosurgical Focus contains 15 new articles on the principles of enhanced recovery after surgery and how these principles relate to spine surgery.
This article provides the reader with a glimpse of how effective lumbar surgery in select patients can be when performed without general anesthesia, open surgery, or a long convalescence in the hospital.
Bioscientists at Rice and the University of Maryland with the Center for Engineering Complex Tissues learn to 3D-print scaffolds that may help heal osteochondral injuries of the sort suffered by many athletes.
Researchers at the Institute of Cognitive Neuroscience of the Higher School of Economics have proposed to train transplanted muscles in advance with new movements so that the brain can learn to use them more quickly after autotransplantation. The results of the study on the prospects of this approach were published in the article 'Perspectives for the Use of Neurotechnologies in Conjunction with Muscle Autotransplantation in Children'.