A team of leading European clinicians and scientists presents a unique perspective on how to move forward in the development of exon skipping therapies to treat the severe muscle-wasting disease Duchenne Muscular Dystrophy (DMD).
A new study published in the Journal of Orthopaedic Research indicates that certain genetic changes are linked with an increased risk of developing lumbar spinal stenosis, a narrowing of the open spaces in the lower spine that can lead to pain in the legs when individuals walk.
A study published online in The FASEB Journal suggests that resistance training may prevent age-related tendon problems, such as ruptures and tendinopathies.
New research published in the Journal of Physiology today suggests that enhancing breathing via the brain may limit deficiencies in respiratory capacity in Duchenne muscular dystrophy patients.
Treating patients suffering from neck pain with exercise therapy alone seems to be as effective as combining exercise and manual therapies, according a new study.
Osteoarthritis of the knee may not be totally preventable but according to Elizabeth Matzkin, MD, an orthopaedic surgeon specializing in sports medicine with Brigham and Women's Hospital, there are some key factors that we can control to minimize the chances of developing bone and joint pain. What's the best treatment option for those who already have knee OA? Dr. Matzkin explains her study's findings published in the Journal of the American Academy of Orthopaedic Surgeons.
A new study published in the journal Nature Communications describes a breakthrough in research related to facioscapulohumeral muscular dystrophy (FSHD). The debilitating genetic disease -- which has no approved treatment -- affects an estimated 38,000 Americans and causes muscle degeneration. Scientists inserted into mice a gene called DUX4, which is believed to cause FSHD in humans. When they activated the gene in mice skeletal muscle cells, the animals developed a muscular dystrophy with key features of FSHD.
A group of researchers at Instituto de Medicina Molecular (iMM) Lisboa has revealed the mechanism by which cellular nuclei reach their position within muscle cells. This discovery, now published in Nature Cell Biology, can have important implications in therapeutic strategies to treat muscular diseases.
Loss of muscle is an inevitable consequence of aging that can lead to frailty, falls or mobility problems. Eating enough protein is one way to remedy it, but it would seem that spreading protein equally among the three daily meals could be linked to greater mass and muscle strength in the elderly. These are the findings of a study conducted at the Research Institute of the McGill University Health Centre in Montreal.
A novel cartilage degeneration algorithm can predict the progression of osteoarthritis in individual patients, according to new research from the University of Eastern Finland. The new algorithm could greatly facilitate clinical decision-making in the treatment of osteoarthritis.