A rare genetic disorder in which people are suddenly overcome with profound weakness or temporary paralysis is caused by a hole in a membrane protein that allows sodium ions to leak across cell membranes. The results of a new study reveal the mechanisms of periodic paralysis at the atomic level and suggest designs for drugs that may prevent this ion leak and provide relief to these patients
Researchers from the University of Jyväskylä in Finland have found that continued treatment of muscle wasting with a soluble growth factor receptor protein, produced at the University of Helsinki, improved survival in a preclinical cancer model without affecting the tumor size. This effect was not found when the mice were treated with the recombinant protein only prophylactically before cancer.
For high school baseball pitchers, limiting throws during a game helps to prevent fatigue and injuries. But nearly half the number of pitches -- ones thrown during warm-ups and in the bullpen -- are typically not counted, adding significantly to a pitcher's risk of injury, new findings by University of Florida Health researchers show.
Researchers at CSHL have published a proof of concept for a therapeutic RNA drug to correct the error in RNA splicing that causes familial dysautonomia (FD), a rare inherited neurodegenerative disorder.
For athletes and weekend warriors alike, returning from a tendon injury too soon often ensures a trip right back to physical therapy. However, a new technology developed by University of Wisconsin-Madison engineers could one day help tell whether your tendons are ready for action.
People with tremors in their hands from a condition called essential tremor may find some relief from a new, noninvasive type of nerve stimulation, according to a preliminary scientific abstract released today that will be presented at the American Academy of Neurology's 70th Annual Meeting in Los Angeles, April 21-27, 2018.
While women are two to four times more likely than men to tear the anterior cruciate ligament (ACL) in their knee, the cause of this injury is no different between the sexes, according to new research from Duke Health.
A preliminary study suggests that an investigational drug may help increase protein levels in babies with spinal muscular atrophy. The open-label study is released today and will be presented at the American Academy of Neurology's 70th Annual Meeting in Los Angeles, April 21-27, 2018.
Decreased HDL and ApoA-l levels in the general population are associated with an increased risk of death from cardiomyopathy and heart failure. Researchers found the FA patients had serum ApoA-I levels lower than healthy control subjects. In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol-lowering drug increased a precursor of HDL (high-density lipoprotein), the "good cholesterol."
The inactivity of astronauts during spaceflights presents a significant risk to their muscles, says a new study in The Journal of Physiology. Scientists have simulated the impact of 21-day spaceflights on the body, and the impact of low gravity environments such as the moon or Mars.