Steroids are currently the only available treatment to reduce the repetitive cycles of inflammation and disease progression associated with functional deterioration in patients with muscular dystrophy (MD). A study reported in The American Journal of Pathology showed that a new treatment approach using the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene significantly improved cardiac, respiratory, and skeletal muscle functions and increased bone density in both male and female mice with the same gene defects as a subset of patients with MD.
Cells made by fusing a normal human muscle cell with a muscle cell from a person with Duchenne muscular dystrophy -- a rare but fatal form of muscular dystrophy -- were able to significantly improve muscle function when implanted into the muscles of a mouse model of the disease.
Diagnostic and treatment advances are helping patients with Duchenne muscular dystrophy live into their 30s and beyond, raising challenges in such areas as education, vocation, levels of independence, personal relationships, emotional health, and intimacy. To address these shifting circumstances, as well as reflect promising new treatment options, new guidelines aimed at physicians who care for DMD patients have recently been issued.
New research published today helps explain why people experience muscle loss in old age, increasing the prospects of reversing the condition in the future.
Cortisone injections are a common nonsurgical approach to treating rotator cuff injuries. However, researchers presenting their work today at the American Orthopaedic Society for Sports Medicine's Specialty Day in New Orleans suggest that individuals who receive injections less than six months before a rotator cuff repair may have an increased risk for revision rotator cuff repair.
Isolated femoral condyle lesions account for 75 percent of the cartilage repair procedures performed in the knee joint, and physicians have a variety of techniques to consider as part of surgical treatment. Osteochondral allograft transplantation (OCA) is a valuable and successful approach for this condition, as described by research presented today at the American Orthopaedic Society for Sports Medicine's Specialty Day in New Orleans.
Nonoperative treatment of high school athletes with shoulder instability is an effective approach, according to research presented today at the American Orthopaedic Society for Sports Medicine's Specialty Day in New Orleans. Researchers also noted that using the Non-Operative Instability Severity Score (NSIS) tool can help identify higher-risk patients who may require other forms of treatment.
People who live in areas where they are exposed to more of the sun's rays, specifically UV-B rays, may be less likely to develop multiple sclerosis (MS) later in life, according to a study published in the March 7, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology. Exposure in childhood and young adulthood may also reduce risk.
ERRγ gene enables endurance exercise and repairs type of damage seen in neuromuscular diseases.
Children who are vitamin D deficient have a greater risk of having more severe forearm fractures requiring surgical treatment, according to a new study presented today at the 2018 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS). This is the first report that shows the important link between low vitamin D levels and the severity of fractures in children caused by low-energy, less traumatic events such as falling off a bike or falling while running.