Four in 10 people with advanced multiple sclerosis, or MS, are emotionally abused by someone responsible for caring for them, reports a study led by the University of California, Riverside. Further, the study finds one quarter are financially exploited, one in six are neglected, one in nine are battered, and one in 12 are sexually assaulted by a caregiver.
Researchers building a model of muscle damage in a cultured system found that components leaking from broken muscle fibers activate "satellite cells," which are muscle stem cells. While attempting to identify the activating proteins, they found that metabolic enzymes, such as GAPDH, rapidly activated quiescent satellite cells and accelerated muscle injury regeneration. This is a highly rational and efficient regeneration mechanism, in which the damaged muscle itself activates satellite cells for regeneration.
Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice. This was not observed in male mice that lacked the ERβ gene, suggesting that estrogen and its downstream signals may be a female-specific mechanism for muscle growth and regeneration.
University of South Australia researchers are a step closer to finding a new biomarker for osteoarthritis, a painful condition which affects more than 300 million people worldwide.
A new study published in Arthritis Care & Research has examined patterns of 24-hour physical activity and sleep among patients with rheumatoid arthritis, lupus, and knee osteoarthritis.
A new Danish study from the Department of Sports Science and Clinical Biomechanics at the University of Southern Denmark recently showed, that if athletes can place their glycogen close to the structures that produce the force in the muscle cells, they can cycle for a longer time, than if their glycogen is placed elsewhere in the muscle cells. In other words, the research results suggest that it is more important where the sugar is stored than how much there is.
A research team at Nagoya University has revealed that narrow-range ultraviolet (UV) irradiation using light emitting diodes (LEDs) safely increases serum vitamin D levels in aging mice and thereby prevents the loss of their bone and muscle mass.
A new study reveals the impact of lockdown for people with bone, joint and muscle pain. It finds that the majority of people with musculoskeletal pain reported increased symptoms. And those who experienced most social isolation and loneliness were less likely to access healthcare. The findings are the result of a survey of more than 600 people across the UK to see how people with bone, joint and muscle pain coped in lockdown.
An analysis of genetic data collected from more than 850,000 individuals of European ancestry has found a link between obesity-related genes and rheumatoid arthritis.
While disease activity improves over time for most rheumatoid arthritis (RA) patients, long-term outcomes only improve in RA patients with autoantibodies, according to a new study published this week in PLOS Medicine by Xanthe Matthijssen of Leiden University Medical Center, Netherlands, and colleagues. The findings add to a growing body of evidence that RA with and without autoantibodies are two distinct conditions.