People with Rheumatoid Arthritis (RA) could soon benefit from a new drug treatment, otilimab, that not only suppresses inflammation but also significantly reduces patient reported pain scores.
As people age, joints become less flexible, causing balance problems that lower quality of life. Dr. Kosuke Hirata, Mr. Ryosuke Yamadera, and Prof. Ryota Akagi from the Shibaura Institute of Technology revealed that among younger adults, muscle but not nerve stiffness is associated with the ankle's range of motion (ROM), whereas only nerve stiffness is linked to ankle ROM among older adults. In other words, non-muscle tissue becomes more important for joint flexibility with age.
Researchers have identified a unique population of astrocytes in the dorsal horn of the spinal cord of mice that produces pain hypersensitivity when activated by neurons carrying signals down from the brain. The findings indicate that the role of descending neurons in controlling spinal pain transmission is not limited to suppression and point to this group of astrocytes as a new target for enhancing the effect of chronic pain treatments.
A new study published in The BMJ shows that people who had surgery to improve blood flow in their legs under spinal or epidural anesthesia were less likely to die than those who were given general anesthesia.
Results of a new study show that opioid overdose deaths involving more than one substance (polysubstances) are more common than opioid-only overdose deaths among youth. Led by researchers at Boston Medical Center's Grayken Center for Addiction, the data shows that cocaine and other stimulants like crystal methamphetamine are the substances most commonly involved in opioid overdose deaths in young people between the ages of 13 and 25.
A bird-catching Chinese tarantula bite contains a stinger-like poison that plunges into a molecular target in the electrical signaling system of their prey's nerve cells. New cryo-electron microscopy studies show how this venom traps the voltage sensors of sodium channels in a resting state so they can't be activated. Such research may suggest designs for better drugs for chronic pain.
Giving nurse practitioners the authority to prescribe buprenorphine has brought that gold standard treatment for opioid addiction to people who might not have had access to it before, according to a new study. Looking at prescription drug monitoring data in Oregon before and after 2017, when nurse practitioners and physician assistants gained the authority to prescribe buprenorphine, researchers found that nurse practitioners almost immediately had an impact on access to buprenorphine in rural Oregon.
According to AJR, although pediatric CT use has decreased for the evaluation of abdominal pain (perhaps due to implementing an ultrasound-first strategy for suspected appendicitis), CT use has continued to increase among adults with abdominal pain in U.S. emergency department (ED) visits. Although trends in CT use have previously been reported for children and adults, this study is the first to contrast the two cohorts in the ED setting in a nationally representative sample.
A new study of Canadians aged 45-85, released this week in the International Journal of Social Psychiatry, found that 24% of refugees were in psychological distress compared to 13% of non-refugee immigrants and those born in Canada.
Racket sports like tennis and racquetball appear to accelerate knee joint degeneration in overweight people with osteoarthritis, according to a study being presented at the annual meeting of the Radiological Society of North America (RSNA).