Managing gout as a chronic, rather than an acute, condition could help prevent recurrences. A new study of more than 8,000 medical records found a positive association between starting treatment with allopurinol, a medication that helps prevent gout by lowering production of uric acid, and recurring doctor visits for the condition. Clinicians may therefore be more likely to offer allopurinol, or patients may be more likely to accept it, after multiple acute gout attacks.
Patients and family members are either neutral or uncomfortable with the idea of 'overlapping' or 'concurrent' surgery, where the attending surgeon isn't present in the operating room for part of the procedure, according to survey results published in the November 15, 2017 issue of The Journal of Bone & Joint Surgery. The journal is published in partnership with Wolters Kluwer.
Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, matches existing data about FDA-approved drugs to diseases, and predicts potential drug efficacy. In a recent study published in Oncogene, the researchers successfully translated DrugPredict results into the laboratory, and showed common pain medications--like aspirin--can kill patient-derived epithelial ovarian cancer cells.
Opioid pain relievers can be extremely effective in relieving pain, but can carry a high risk of addiction and ultimately overdose when breathing is suppressed and stops. Scientists have discovered a way to separate these two effects -- pain relief and breathing -- opening a window of opportunity to make effective pain medications without the risk of respiratory failure. The research, published today in Cell, was funded by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health.
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have developed new opioid pain relievers that reduce pain on par with morphine but do not slow or stop breathing -- the cause of opiate overdose.
Despite an FDA black box warning against prescribing children codeine following tonsil and adenoid removal, 1 in 20 children undergoing these surgeries continued to receive the opioid, a new study suggests.
If you visit your family doctor with low back pain (LBP), you may be surprised at the treatment options they suggest now. Recent changes to major international guidelines for the management of LBP mean that general practitioners (GP) are now unlikely to recommend pain medicines which were previously the go-to treatment. Instead of pain medicines, GPs might suggest non-medicinal approaches including yoga, mindfulness and various types of physiotherapy and psychological therapies.
Pregnant women with opioid use disorder (OUD) are more likely to receive evidence-based treatment with an 'opioid agonist' -- usually methadone -- in states where those medications are covered by Medicaid, reports a study in the December issue of Medical Care, published by Wolters Kluwer.
New research on the biological basis of psychiatric disorders has important implications for legal proceedings as well as mental health treatment, according to a special issue on 'Psychiatry, Neuroscience, and the Law,' presented in the Harvard Review of Psychiatry. The journal is published by Wolters Kluwer.
New research from York University's OUCH Cohort at the Faculty of Health found that the amount of distress and pain felt by a preschooler during a vaccination is strongly related to how to their parents help them cope before and during an appointment.