A recent paper published in the journal Molecular Psychiatry explores how a protein named CK2 could play a key role in the formulation of new antidepressants that work more efficiently and faster for more people.
Many drugs work by inhibiting protein enzymes associated with a particular disease. Unfortunately, the same drugs can inhibit protein enzymes unrelated to the disease, resulting in harmful side effects. Computational biologists have a way to identify the features that distinguish one enzyme from similar enzymes. This research has the potential to significantly accelerate drug discovery, allowing scientists to develop more effective drugs, more quickly.
A group of scientists from the Siberian Federal University (SFU, Krasnoyarsk, Russia) and the Nikolaev Institute of Inorganic Chemistry (NIIC, Novosibirsk, Russia) combined the useful properties of metal phthalocyanines and palladium membranes in order to create active layers in hydrogen detectors. This operation significantly increases the sensitivity of the sensors. The study is reported in the journals Dyes and Pigments and International Journal of Hydrogen Energy.
For patients who have never been prescribed opioids, larger numbers of tablets given with the initial prescription is associated with long-term use and more tablets leftover that could be diverted for misuse or abuse. Implementing a default option for a lower quantity of tablets in the electronic medical records (EMR) discharge orders may help combat the issue by 'nudging' physicians to prescribe smaller quantities consistent with prescribing guidelines Penn Medicine researchers show in a new study.
Named after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metabolism. In a recent Yale-led study, researchers revealed the three-dimensional structure of one of these proteins, beta-Klotho, illuminating its intricate mechanism and therapeutic potential.
A new original research article in SLAS Discovery presents a fast, sensitive, and robust methodology for screening small molecule inhibitors against CD73/Ecto-5'-Nucleotidase, a promising target for developing anti-cancer drugs.
Previously unpublished information from the clinical trial that the US Food and Drug Administration relied on to approve the most commonly prescribed medicine for nausea in pregnancy indicates the drug is not effective, a new report says.
An international science team has developed an innovative therapeutic complex based on multi-layer polymer nano-structures of superoxide dismutase (SOD). The new substance can be used to effectively rehabilitate patients after acute spinal injuries, strokes, and heart attacks.
Pharmaceuticals and other man-made contaminants are forcing fish that live downstream from a typical sewage treatment plant to work at least 30 percent harder just to survive, McMaster researchers have found.
A rare glimpse into the prior authorization requirements implemented by public and private insurance providers across the country has found substantial administrative burden for a new class of medications for patients with high cholesterol that places them at high risk for heart attack or stroke, according to new research.