Prescription cough and cold medicines containing the opioid hydrocodone were more likely to cause serious side effects in children than those containing codeine, according to a new study from Penn State College of Medicine. The research supports recent U.S. Food and Drug Administration (FDA) restrictions on prescription hydrocodone- and codeine-containing cough medicines for children and suggests that opioids in general should not be prescribed for coughs and colds in pediatric populations.
A non-surgical procedure, called percutaneous coronary intervention (PCI), along with prescribed medication, is better than medication alone as initial treatment for people who have the most common form of heart disease, suggests an analysis of an international clinical trial co-led by St. Michael's Hospital.
In a discovery that points to potential new antibiotic medicines, scientists from Rice University and the University of Michigan have deciphered the workings of a common but little-understood bacterial switch that cuts off protein production.
Furanosteroids, represented by wortmannin and viridin, are a special group of highly-oxygenated steroids featured by a furan ring. They are well-known nanomolar-potency inhibitors of phosphatidylinositol 3-kinase (PI3K) and widely used in biological studies. Here, we report the first identification of the biosynthetic gene cluster for demethoxyviridin in symbiotic fungi. Structure-activity analyses of the biosynthetic intermediates revealed that the 3-keto group, the C1β-OH, and the aromatic ring C are important for PI3K inhibition.
Scientists have found a new way of joining groups of atoms together into shape-changing molecules -- opening up the possibility of a new area of chemistry and the development of countless new drugs, microelectronics and materials. Discoveries of new ways to make isomers -- molecules made of the same atoms connected together differently -- were last reported in 1961 and before then in 1914. Proof-of-principle and prototype demonstration of this important finding are expected within 30 months.
A rare genetic disorder in which people are suddenly overcome with profound weakness or temporary paralysis is caused by a hole in a membrane protein that allows sodium ions to leak across cell membranes. The results of a new study reveal the mechanisms of periodic paralysis at the atomic level and suggest designs for drugs that may prevent this ion leak and provide relief to these patients
Rheumatologists and rheumatology health professionals convened on Capitol Hill this week to urge legislative action on pressing policy issues affecting rheumatology care during the American College of Rheumatology's Advocacy Leadership Conference, held May 16-17, 2018 in Washington, D.C.
Researchers at University of California San Diego School of Medicine and their collaborators have developed a technique that allows them to speed up or slow down human heart cells growing in a dish on command -- simply by shining a light on them and varying its intensity. The cells are grown on a material called graphene, which converts light into electricity, providing a more realistic environment than standard plastic or glass laboratory dishes.
This vision of simplifying disease diagnosis using topically applied nanotechnology could change the way skin diseases such as abnormal scars are diagnosed and managed.
HIV patients on a single-tablet daily regimen had better outcomes than patients taking multiple pills per day, in a study that included a researcher at the Michael E. DeBakey Veterans Affairs Medical Center in Houston.