Researchers have determined that cannabinoid drugs do not appear to reduce the intensity of experimental pain, but, instead, may make pain feel less unpleasant and more tolerable. The paper, whose publication coincides with 'Pain Awareness Month,' represents the first systematic review of experimental research into the effects of cannabis on pain.
The spatial and temporal dynamics of proteins or organelles plays a crucial role in controlling various cellular processes and in development of diseases. Yet, acute control of activity at distinct locations within a cell cannot be achieved. In the journal Angewandte Chemie, scientists from Umeå University (Sweden) and the Max Planck Institute of Molecular Physiology (Germany) present a new chemo-optogenetic method that enables tunable, reversible, and rapid control of activity at multiple subcellular compartments within a living cell.
Infection with human papillomavirus (HPV) can cause certain cancers in women and men, but HPV vaccines are highly effective in preventing infection with oncogenic HPV types. A new British Journal of Clinical Pharmacology review of post-licensure data did not identify any new or unexpected safety concerns of the bivalent HPV vaccine.
New University of Otago research shows infants using popular anti-reflux medicines like omeprazole are not at increased risk of pneumonia or other lower respiratory tract infections, contrary to findings from other international studies.
Researchers at University of California San Diego School of Medicine have unraveled new insights into the way cells leverage G-protein-coupled receptors (GPCRs) and their cellular waste disposal systems to control inflammation. The findings, published Sept. 18, 2018 in Cell Reports, suggest some existing cancer drugs that inhibit these cellular activities might be repurposed to treat vascular inflammation, which occurs when artery-blocking plaques form in atherosclerosis.
One of the challenges in cancer research is improving the delivery of chemo drugs to enhance their efficacy while decreasing the risk of side effects. In a new study published in EPJ E, Scientists from Argentina perform a theoretical prediction of adsorption of a well-known chemo drug onto active carbon with aluminium inclusions, to show its potential as an oral chemotherapy delivery capsule.
Our result suggests preoperative albumin level as an independent risk factor for PPCs in elderly gastric cancer (GC) patients after elective laparoscopic gastrectomy. We also suggest that those elderly hypoalbuminemic GC patients may benefit from more intensive perioperative care including perioperative nutritional status improvement.
Team of University of Colorado Cancer Center researchers sheds light on p63 activity in squamous cell carcinoma of the lung, providing an actionable path forward to drug development against this known cause of cancer.
Muscle relaxants are a necessary part of anesthesia during certain major operations. Studies have, however, hinted at respiratory risks connected with these drugs. POPULAR, a major prospective observational European study supported by the European Society of Anaesthesiology (ESA) and led by the Technical University of Munich (TUM), has confirmed the association between use of muscle relaxants and respiratory complications and assessed the chances of the current avoidance strategies.
A team of researchers, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has identified variables that control the cavity-filling rates, required for liquids to penetrate into the cavities.