A University of Colorado Cancer Center study published today in the journal Molecular Cancer Therapeutics finds a genetic change called ALK-fusion in a patient sample of a melanoma subtype called mucosal melanoma. When researchers treated a tumor grown from this sample with the drugs crizotinib and ceritinib -- both FDA approved to treat ALK-positive lung cancer -- the tumor responded dramatically.
Researchers from the Walter Reed National Military Medical Center conducted a prospective, observational study to assess the impact that weight and renal function have on venous thromboembolism (VTE) rates among in-patients receiving prophylaxis with low-molecular-weight or unfractionated heparin.
Researchers have discovered that a virus-like particle vaccine can prime the body's immune response and prevent the severe respiratory disease that results when patients given an early form of a vaccine for respiratory syncytial virus (RSV) are exposed to RSV, according to a study led by Georgia State University.
In healthy people, exosomes -- tiny structures secreted by cells to allow intercellular communication -- prevent clumping of the protein that leads to type 2 diabetes. Exosomes in patients with the disease don't have the same ability. This discovery by a research collaboration between Chalmers University of Technology and Astrazeneca takes us a step closer to a cure for type 2 diabetes.
A new five-year study of nearly 1,600 patients finds that genetic testing can help determine the safest dose of the blood thinner warfarin, with fewer side effects, in patients undergoing joint replacement surgery.
Biosimilar drugs have been touted as one strategy to help curb the runaway costs of biologics that have advanced the treatment of illness such as rheumatoid arthritis and many cancers. A new study finds biosimilars could cut health care spending in the United States by $54 billion over the next decade. The savings are about 20 percent larger than a similar, widely cited analysis done three years ago by the same researchers.
A new study offers a rare glimpse into the genetics of a herpes simplex virus transmission event -- information that may prove useful in future development of therapeutics and vaccines. The study reveals nearly perfect genetic transmission of the virus from a father to his son and lays the foundation for future studies exploring the genetic diversity of this virus.
New oral anticoagulants (NOACs) represent direct-acting drugs functioning selectively for one specific clotting factor. Their clinical indications are the prophylaxis and treatment of deep venous thrombosis and pulmonary embolism, the prevention of atherothrombotic episodes of individuals with acute coronary syndromes and atrial fibrillation
A new vaccine under development provoked an immune response to 72 forms of the bacteria that's responsible for pneumonia, sepsis and meningitis. That's up from the 23 forms of bacteria covered by current immunizations. The new vaccine, which represents the 'most comprehensive' coverage of pneumococcal disease to date, could greatly reduce the number of deaths from the disease.
Oregon shore crabs exhibit risky behavior when they're exposed to the antidepressant Prozac, making it easier for predators to catch them, according to a new study from Portland State University (PSU).