As hospitalized COVID-19 patients undergo experimental therapy, research published in the Journal of Biological Chemistry explains how the drug, remdesivir, stops replication in coronaviruses.
A group of University of Alberta researchers who have discovered why the drug remdesivir is effective in treating the coronaviruses that cause Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) expect it might also be effective for treating patients infected with the new COVID-19 strain.
The same way baking soda breaks down grease and grime, making surfaces easier to clean, researchers at the Lewis Katz School of Medicine at Temple University now show that a new therapeutic molecule can break apart communities of harmful bacteria, opening the way for bacteria-killing antibiotics to more effectively clear out infections.
Older people's risk of recurrent fractures decreases by 18 percent if the care they receive is more structured and preventive, through fracture liaison services. This is shown by a study from the University of Gothenburg, Sweden.
Researchers have used cryo-electron microscopy to elucidate for the first time the structure and function of a very small enzyme embedded in cell membranes. This enzyme builds complex sugar trees that are subsequently attached to other membrane proteins. The findings could accelerate the development of new, protein-based medications.
Scientists have solved a puzzle that has long baffled botanists -- why some plants on high mountainsides are hairy while their low-lying cousins are bald.
Scientists at Trinity College Dublin have identified a rare, new cell in the immune system with 'Jekyll and Hyde properties.' These cells play a key protective role in immunity to infection but -- if unregulated -- also mediate tissue damage in autoimmune disorders. The findings should help us design more effective vaccines to prevent infections such as MRSA, and may also assist help us develop of new therapies for autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis.
Developing new drugs and vaccines for diseases like the COVID-19 coronavirus can take years. A survey of existing drugs shows a number of candidates in different phases of clinical testing that might offer hope.
One of the most frequent problems when treating cancer is that the tumors develop resistance to therapies. This is especially relevant in patients with aggressive diseases. A study led by the Spanish National Cancer Research Centre (CNIO) in collaboration with the Weill Cornell Medicine Center and Pfizer Inc. (United States) proposes a novel combined approach to avoid pancreatic cancer resistance to chemotherapy, and thus achieve that the treatments eliminate these tumor cells effectively.
Roughly 80% of people with myotonic dystrophy -- a common form of muscular dystrophy -- experience dangerous heart ailments, and heart rhythm defects are the second-leading cause of death in those with the condition. In a new study, researchers traced the molecular events that lead to heart abnormalities in myotonic dystrophy and recreated the disease in a mouse model.