In an editorial to be published on Tuesday June 27, 2017 in the journal ecancermedicalscience, Anthony Hatswell of BresMed and University College London, explores the consequences of a British exit from the European Medicines Agency as a result of Brexit, and what this will mean for pharmaceutical regulation and future access to medicines for UK citizens.
A team of chemical and biomolecular engineers at the University of Notre Dame have developed a novel platform to more accurately detect and identify the presence and severity of peanut allergies, without directly exposing patients to the allergen.
Despite dramatic reductions in the death rate from cardiovascular disease, which includes heart disease and stroke, it remains the leading causes of death, and experts have expressed concern that the number of new therapies coming to market has lagged.
Researchers from Kumamoto University in Japan have found that the compound folic acid-conjugated methyl-BETA-cyclodextrin (FA-M-BETA-CyD) has significant antitumor effects on folate receptor-ALPHA-expressing (FR-ALPHA (+)) cancer cells. The compound significantly reduced ATP production while simultaneously increased the production of reactive oxygen species. Side effects in animal models were minimal but further testing is still required to determine its safety.
An international research team has found a way to improve the anti-cancer effect of a new medicine class called 'Smac mimetics.'
The first results from a functional genetic catalogue of the laboratory mouse has been shared with the biomedical research community, revealing new insights into a range of rare diseases and the possibility of accelerating development of new treatments and precision medicine.
Discovering the function of a gene requires cloning a DNA sequence and expressing it. Until now, this was performed on a one-gene-at-a-time basis, causing a bottleneck. Scientists at Rutgers University-New Brunswick in collaboration with Johns Hopkins University and Harvard Medical School have invented a technology to clone thousands of genes simultaneously and create massive libraries of proteins from DNA samples, potentially ushering in a new era of functional genomics.
Health Canada's proposed changes to natural health product regulation are a good step forward, but they need to go further to protect consumers, argues Dr. Matthew Stanbrook in an editorial in CMAJ.
For the first time, scientists have visualized the fine details of bacterial microcompartment shells -- the organisms' submicroscopic nanoreactors, which are comprised completely of protein.
In a study published in Current Biology on June 22, the lab of Professor John Werren at the University of Rochester describes how four closely related species of parasitic wasps change their venoms rapidly in order to adapt to new hosts, and proposes that co-option of single copy genes may be a common but relatively understudied mechanism of evolution for new gene functions, particularly under conditions of rapid evolutionary change.