Patients with albuminuria will usually need more than one drug to achieve blood pressure control, particularly if the aim is also to reduce albuminuria.
To carry out wide range of cellular functionalities, proteins often associate with one or more proteins in a phenomenon known as Protein-Protein Interaction (PPI). Experimental and computational approaches were applied on PPIs in order to determine the interacting partners, and also to understand how an abnormality in such interactions can become the principle cause of a disease.
Researchers at Carnegie Mellon University have used nuclear resonance vibrational spectroscopy to probe the hydrogen bonds that modulate the chemical reactivity of enzymes, catalysts and biomimetic complexes. The technique could lead to the development of better catalysts for use in a wide range of fields. The findings were published as a 'Very Important Paper' in the Dec. 3 issue of Angewandte Chemie and featured on the journal's back cover.
Researchers have discovered a 'blind spot' in atomic force microscopy -- a powerful tool capable of measuring the force between two atoms, imaging the structure of individual cells and the motion of biomolecules.
Virginia Commonwealth University researchers are testing a vaccine against opioid abuse developed by the Scripps Research Institute in California. The vaccine is meant to block the effects of heroin and fentanyl in patients with opioid use disorder.
Purdue University researchers have developed a series of molecules that may provide more reliable relief with fewer side effects for people with any of several autoimmune diseases. The new molecules overcome difficulties with current drugs in targeting, for purposes of inhibiting, the appropriate form of Janus kinase, which has four forms affecting cell signaling and gene expression.
5, 10, or maybe 15? How many nanometers should nanoparticles of a catalyst be to optimize the course of the reaction? Researchers usually look for the answer by laborious, repetitive tests. At the Institute of Physical Chemistry of the Polish Academy of Sciences in Warsaw, a qualitatively new technique was developed to improve the process of such optimization in microfluidic systems. The size of the catalyst nanoparticles can now be changed interactively, during a continuous flow through the catalyst bed.
Pharmaceuticals are often dosed according to patient weight or body size which means that a dose must be individually measured. In a new study, lead author Anthony Hatswell of Delta Hat Limited and University College London in the UK, shows that by optimizing drug dose sizes available, wastage can be cut by as much as 50 per cent.
Medication administration errors leading to death are common with anticoagulants and antibiotics in particular, according to a new study that analyzed incidents reported in England and Wales. The most common error category was omitted medicine, followed by a wrong dose or a wrong strength. In half of the reported incidents, the patient was aged over 75.
There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. In a new study published in Science Signaling, they identify how these receptors are activated in the cell membrane and the processes that are then triggered within the cell.