Paracetamol during pregnancy can inhibit masculinity Paracetamol during pregnancy can inhibit the development of 'male behavior' in mice. New research from the University of Copenhagen shows that it can reduce sex drive and aggressive behavior.
New research overturns long-held views on a basic messaging system within living cells. Key cellular communication machinery is more regionally constrained within the cell than previously thought. The findings suggest new approaches to designing precision drugs. Localizing drug action at a specific 'address' within the cell could mean fewer side effects in treating cancer, diabetes, heart disease and other serious conditions.
Oxazaphosphorine cytostatics (Cyclophosphamide, Ifosfamide) are often used and very effective anticancer agents; but so far little is known about the molecular basis for the antitumor effect.
Antibiotics were the wonder drug of the 20th century, but persistent use and over-prescription have opened the door that has allowed bacteria to evolve resistance. According to the CDC, more than two million people in the US develop bacterial infections that are resistant to multiple antibiotics every year. Researchers at University of Utah Health developed a rapid screening method to pair existing FDA-approved drugs to combat multi-drug resistant bacterial infections.
As the HIV/AIDS epidemic approaches its fourth decade, each year brings promising news of pioneering research to alleviate the scourge. Add City College of New York scientists to the list with a rapid method to access new molecules that could inhibit the virus that causes AIDS.
A team of researchers has developed a program that automates the process of figuring out a molecule's three-dimensional structure. The technique compresses a process that usually takes days into minutes and could shorten the pipeline of drug discovery by reducing human error.
Researchers in Ireland have taken a major step forward in the battle against medical implant infections. They developed a new type of implant scaffold to provide localised drug treatment and prevent infection, which has already proven effective against two types of major problem bacteria.
Pulsed cavitation ultrasound can be used to remotely soften human degenerative calcified biosprosthetic valves and significantly improve the valve opening function, according to a novel study published today in JACC: Basic to Translational Science. This new noninvasive approach has the potential to improve the outcome of patients with severe bioprosthesis stenosis.
Cell-killing chemotherapies are designed to shrink cancerous tumors by accumulating in their ill-formed blood and lymph vessels, delivering a toxic dose to the cancer cells. A team of researchers at the Wyss Institute has developed a new drug delivery platform that uses safe, low-energy ultrasound waves to trigger aggregates of chemotherapy-containing nanoparticles to break apart precisely at tumor sites, resulting in dramatically improved targeting efficacy and toxicity profile in mouse models of breast cancer.
A team of Rutgers University-New Brunswick, NAICONS Srl., and other scientists has discovered a new antibiotic effective against drug-resistant bacteria: pseudouridimycin. The new antibiotic is produced by a microbe found in a soil sample collected in Italy and was discovered by screening microbes from soil samples. The new antibiotic kills a broad spectrum of drug-sensitive and drug-resistant bacteria in a test tube and cures bacterial infections in mice.