Among women with breast cancer, colorectal cancer, or melanoma, those who were taking cholesterol-lowering medications, were less likely to die from cancer, according to an analysis published in the British Journal of Clinical Pharmacology.
Researchers in this randomized clinical trial compared the effect of early administration of tocilizumab with standard therapy in preventing clinical worsening in patients hospitalized with COVID-19 pneumonia.
Whether treatment with tocilizumab in the first two days after being admitted to an intensive care unit was associated with a reduced risk of death among critically ill patients with COVID-19 was investigated in this study.
Bacteria in the small intestine can deaminate levodopa, the main drug that is used to treat Parkinson's disease. Bacterial processing of the unabsorbed fractions of the drug results in a metabolite that reduces gut motility. These findings were described in the journal BMC Biology on 20 October by scientists from the University of Groningen. Since the disease is already associated with constipation, processing of the drug by gut bacteria may worsen gastrointestinal complications.
University of New Mexico researchers identify three existing drugs with the potential to clear SARS-CoV-2 infections.
Multidrug resistance (MDR) -- a process in which tumors become resistant to multiple medicines -- is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS' Nano Letters have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR.
Instability of small interfering RNA (siRNA) is one of the obstacles in the development of siRNA-based drugs. Researchers at Tokyo Metropolitan Institute of Medical Science and Tokyo University of Science have developed a new strategy for improvement of siRNA stability by using an artificial cationic oligosaccharide combined with phosphorothioate linkages.
More than 20 million people in the U.S. suffer neuropathic pain. At least 25% of those cases are classified as unexplained and considered cryptogenic sensory polyneuropathy (CSPN). There is no information to guide a physician's drug choices to treat CSPN, but a researcher from the University of Missouri School of Medicine and MU Health Care led a first-of-its-kind prospective comparative effectiveness study.
Testimonials posted on a social media site were analyzed to examine whether individuals are using the cannabis-derived chemical compound cannabidiol (CBD) in an attempt to treat diagnosable conditions that have evidence-based therapies.
Purdue University innovators have created a new method of applying machine learning concepts to the tandem mass spectrometry process to improve the flow of information in the development of new drugs.