Scientists from Russia demonstrated a novel approach leveraging the combination of high-resolution mass spectrometry and chemoinformatics to identify biologically active molecular components of humic substances extracted from coal, and discovered substances with antiviral activity against the tick-borne encephalitis virus. The results of their study were published in the Scientific Reports journal.
Eating disorder researchers at The University of Texas Health Science Center at Houston (UTHealth) have discovered a neurocircuit in mice that, when activated, increased their stress levels while decreasing their desire to eat. Findings appear in Nature Communications.
A Nature Communications paper by Worcester Polytechnic Institute biologist Jagan Srinivasan has shown that a key biological component in the communication system of the nematode C. Elegans can be repurposed to take on a different job,. This critical finding about the workings of evolution could one day affect research into drug interactions, agricultural bio-engineering, and a better understanding of genetic inheritance through multiple generations.
Team of 'green chemists' are working on techniques to produce useful compounds from wood and other fast growing non-edible plant waste, through a chemical process named xylochemistry.
Tiny nanoparticles play a gargantuan role in modern life, but experts have struggled to reach a consensus on the best way to assess and measure them. NIST scientists have concluded that measuring the range of sizes in nanoparticles -- instead of just the average particle size -- is optimal for most applications.
Rice University chemists found a simple route to synthesize azetidines, precursors that make it easier for drug designers to access nitrogen atoms that are key to building new compounds.
Crohn's disease is a form of inflammatory bowel disease (IBD) in which the body's own immune system attacks the gastrointestinal tract, and treatment is focused on controlling the symptoms of the disease in its acute phase and managing it in remission. But recently, researchers at Case Western Reserve University School of Medicine identified a pathway in the immune system activated in CD and which holds promise for investigating new treatments.
According to the study, the strategy has the added advantage of targeting the transmissible phase of the parasite -- the gametocyte.
It has long been known that gold can be used to do things that philosophers have never even dreamed of. The Institute of Nuclear Physics of the Polish Academy of Sciences in Cracow has confirmed the existence of 'gold glue': bonds involving gold atoms, capable of permanently bonding protein rings. Skilfully used by an international team of scientists, the bonds have made it possible to construct molecular nanocages with a structure so far unparalleled in nature or even in mathematics.
Researchers at Tel Aviv University have developed a novel nano-vaccine for melanoma, the most aggressive type of skin cancer. Their approach has so far proven effective in preventing the development of melanoma in mouse models and in treating primary tumors and metastases that result from melanoma.