MIT researchers have designed a machine that can rapidly produce large quantities of customized peptides. This technology could help researchers rapidly generate new peptide drugs to test on diseases including cancer, diabetes, and bacterial infections.
Researchers from Kumamoto University, Japan have developed an insulin release system with sustained and controllable delivery. The system combines two original technologies, SPRA and PPRX, which provide complimentary benefits for insulin delivery.
Development of new strategies and novel drug design to treat trophoblastic diseases and to provide pregnancy success are of crucial importance in maintenance the female reproductive health.
A study demonstrates that the cholesterol present in cell membranes can interfere with the function of an important brain membrane protein, through a previously unknown mode of interaction. Specifically, cholesterol is capable of regulating the activity of the adenosine receptor, by invading it and accessing the active site. This will allow new ways of interacting with these proteins to be devised that in the future could lead to drugs for treating diseases like Alzheimer's.
Chemists at the University of Waterloo, SCIEX and Pfizer have discovered a new way to help the pharmaceutical industry identify and test new drugs, which could revolutionize drug development, and substantially reduce the cost and time drugs need to reach their market.
A product of digesting a micronutrient found in soy may hold the key to why some people seem to derive a heart-protective benefit from eating soy foods, while others do not. Japanese men who are able to produce equol -- a substance made by some types of "good" gut bacteria when they metabolize isoflavones (micronutrients found in dietary soy) -- have lower levels of a risk factor for heart disease than their counterparts who cannot produce it.
Alkaloids are natural nitrogen-containing compounds produced by plants and microbes. These molecules, such as morphine and quinine, are important human medicines. Alkaloids are typically polycyclic in nature. While the polycyclic characteristics are important for their bioactivities, these features impede their chemical syntheses in the laboratory and their applications as pharmaceuticals.
Researchers at Eindhoven University of Technology present a new method that should enable controlled drug delivery into the bloodstream using DNA computers. Led by biomedical engineer Maarten Merkx the team developed the first DNA computer capable of detecting several antibodies in the blood and performing subsequent calculations based on this input. This is an important step towards the development of smart, 'intelligent' drugs that may allow better control of medication with fewer side-effects and at lower cost.
Rice University scientists develop a method to obtain structural details on molecules in lipid membranes near gold nanoparticles. Their method, called SABERS, could help researchers who study drug delivery and amyloid interactions implicated in neurodegenerative disease.
A genomic study of baldness identified more than 200 genetic regions involved in this common but potentially embarrassing condition. These genetic variants could be used to predict a man's chance of severe hair loss. The study, led by Saskia Hagenaars and W. David Hill of The University of Edinburgh, United Kingdom, is published Feb. 14, 2017 in PLOS Genetics.