A theory that has gained considerable attention in international media, including Newsweek and the CBS broadcast 60 minutes, suggest that antidepressant drugs, such as the SSRIs, do not exert any actual antidepressant effect. A research group at the Sahlgrenska Academy has now analyzed data from clinical trials and can rebut this theory.
A new study suggests it may be possible to slow dangerous infections by manipulating the messages microbes send to one another, allowing the body to defeat an infection without causing the bacteria to develop resistance to the treatment.
Treatment of tuberculosis involves a combination of several drugs, sometimes including drugs from a class known as fluoroquinolones. Using computer simulations, scientists have shown that the fluoroquinolone known as moxifloxacin may be superior to two other commonly used fluoroquinolones, according to a new paper in PLOS Computational Biology.
Chemists have discovered a powerful pain reliever that acts on a previously unknown pain pathway. The compound is as effective at relieving neuropathic pain in injured mice as a drug widely used for pain relief called gabapentin. If they can demonstrate that it is safe, effective and nonaddictive in humans -- a process that typically takes years -- the discovery could address one of today's biggest public health challenges: the opioid abuse epidemic.
During a depressive episode, people often report having reduced energy, feeling slowed down and having reduced interest in activities. As their mood lifts, energy and activity return to their usual levels. A new study in Biological Psychiatry reports altered measures of daily activity in patients whose depressive symptoms improved in response to the fast-acting antidepressant ketamine.
Existing evidence on the use of gabapentinoids in chronic low back pain (CLBP) is limited, and demonstrates significant risk of adverse effects with no benefits on pain relief, according to a meta-analysis published in PLOS Medicine by Harsha Shanthanna from McMaster University, Canada, and colleagues.
Scientists from the University of Würzburg have synthesized a complex sugar molecule which specifically binds to the tumor protein Galectin-1. This could help to recognize tumors at an early stage and to combat them in a targeted manner.
Nemours Biomedical Research and the University of Delaware (UD) Department of Materials Science and Engineering have developed a patent-pending process to make 3-D models work in high throughput screening labs, allowing drug discovery to move into more meaningful screening systems. Sigrid Langhans, PhD, of Nemours, along with Darrin Pochan, PhD, of UD and colleagues, published an article about their findings this week in Analytical Biochemistry.
Give your medicine a jolt. By using -- electrochemistry -- a technique that combines electricity and chemistry, future pharmaceuticals -- including many of the top prescribed medications in the United States -- soon may be easily scaled up to be manufactured in a more sustainable way.
Because gamma hydroxybutyric acid (GHB), commonly known as a 'date rape drug' is rapidly absorbed and metabolized by the body, it's difficult for law enforcement to tell if someone has been given GHB. Now, scientists report in ACS' journal Analytical Chemistry that they have identified a potential biomarker that might lead to tests to detect the compound that could be performed much later than current ones.