Yale researchers have developed a way to target RNA with small-molecule drugs, creating a new method for tapping into a vast number of biological mechanisms critical to metabolism and gene expression.
Urban farmers growing vegetables to feed millions of people in Africa's ever-growing cities could unwittingly be helping to spread disease by irrigating crops with wastewater, a new study reveals.
Carnegie Mellon University researchers have identified a molecule that plays a key role in bacterial communication and infection. Their findings add a new word to pneumococcus' molecular dictionary and may lead to novel ways to manipulate the bacteria and prevent infection. The findings are published in the Oct. 11 issue of PLOS Pathogens.
A major cause of human disability and death throughout the world, sepsis is a condition that begins with an infection, progresses rapidly and can set off a chain of effects that result in multiple organ failure and irreparable damage to the body. Because of the condition's rapid onset, physicians must respond immediately to the symptoms with broad-spectrum antibiotics for infection, drugs to combat inflammation and, in the more critical cases, vasopressors to manage shock.
For centuries, gardeners have attempted to breed blue roses with no success. But now, thanks to modern biotechnology, the elusive blue rose may finally be attainable. Researchers have found a way to express pigment-producing enzymes from bacteria in the petals of a white rose, tinting the flowers blue. They report their results in ACS Synthetic Biology.
In neonates with sepsis testing of K. pneumoniae isolates for ESBL production was positive in 60 percent of cases, in neonates with UTI -- in 40 percent of cases. The authors commented that one of key virulence factors -- the rmpA gene -- was found in both groups of infants. This means the prevalence of virulent K. pneumoniae strains is higher than was previously thought, and heavier clinical forms of diseases were found in patients with those virulent strains.
Sepsis remains a common and deadly condition that occurs when the body reacts to an infection in the bloodstream. However, scientists know little about the early stages of the condition. Now, researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC Santa Barbara have discovered that host responses during sepsis progression can vary in important ways based on pathogen type--which could lead to more effective treatments. The study published today in Cell Host and Microbe.
Amphibian populations around the world are declining due to a skin disease caused by fungus. However, an amphibian commonly found in Louisiana, the three-toed amphiuma, has shown a resistance to the fungus, in a new study led by researchers at LSU, Southeastern Louisiana University, Duquesne University and the University of Washington. The study was published in the Journal of Experimental Biology.
A bacterium known for causing stomach cancer might also increase the risk of certain colorectal cancers, particularly among African Americans, according to a study led by Duke Cancer Institute researchers.
Antibiotic resistance in bacteria is a growing global health crisis. Now, new research provides crucial details on bacterial defenses and how we could undermine them.