Researchers from Kanazawa University have found that propionic acid-class nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, form "conjugates" with coenzyme A (CoA) by one of the acyl-CoA synthetases, ACSL1, in liver. These conjugates have the covalent binding ability to cellular proteins that may lead to liver injury, a rare severe side effect of NSAID treatment. This knowledge could help pharmaceutical companies to generate pain control options with fewer risks of severe side effects.
New research shows the Ganges River - with the combined flows of the Brahmaputra and Meghna rivers - could be responsible for up to 3 billion microplastic particles entering the Bay of Bengal every day.
Women with hormone-dependent breast cancer typically have a favorable prognosis, but new research has found that even after adjusting for age at diagnosis, tumor stage and treatment, there is still a significant mortality gap between Black and non-Hispanic white women with axillary node-negative, hormone-dependent tumors that have a comparable Oncotype Recurrence Score.
'What goes in, must come out' is a familiar refrain. It is especially pertinent to the challenges facing UBC researchers who are investigating methods to remove chemicals and pharmaceuticals from public water systems. Cleaning products, organic dyes and pharmaceuticals are finding their ways into water bodies with wide-ranging negative implications to health and the environment, explains Dr. Mohammad Arjmand, an assistant professor of mechanical engineering at UBC Okanagan.
Certain snakes have evolved a unique genetic trick to avoid being eaten by venomous snakes, according to University of Queensland research. Associate Professor Bryan Fry from UQ's Toxin Evolution Lab said the technique worked in a manner similar to the way two sides of a magnet repel each other.
A recent Point of Reference article, "The meat of the matter: Environmental dissemination of beef cattle agrochemicals," published in Environmental Toxicology and Chemistry, points at synthetic chemical cocktails being emitted from cattle feed yards into the environment and how they can impact our ecosystem and our health.
University of California San Diego Herbert Wertheim School of Public Health and Human Longevity Sciences researchers report that starting tobacco products, including e-cigarettes, before the age of 18 is a major risk factor for people becoming daily cigarette smokers.
Drinking water in several cities and regions in China contains high levels of perfluoroalkyl and polyfluoroalkyl substances (PFASs), according to a study published in Environmental Sciences Europe. The findings, from a team of researchers at Tsinghua University, Beijing, China, suggest that elimination of these chemicals from drinking water in affected cities and regions in China is urgently needed and that PFAS released from industries and other sources need better control and reduction.
Currently there's no treatment for botulism once the toxin gets into neurons. This novel treatment neutralized the toxin with a second, modified botulinum toxin that delivered a mini antibody into the cells - reversing paralysis in mice.
In a new study, researchers show that microbes are capable of an incredible feat that could help reclaim a valuable natural resource and soak up toxic pollutants.