Vinorelbine bitartrate (VRL), a semi synthetic vinca alkaloid approved for breast cancer, has been proven to be beneficial as first line and subsequent therapies. However, its hydrophilic and thermo labile nature provides hindrance to oral clinical translation. The current work focused on the application of DOE a modern statistical optimization tool for the development and optimization of a solid lipid nanoparticle (SLN) formulation that can encapsulate hydrophilic and thermolabile Vinorelbine bitartrate (VRL) to a maximum extent without compromising integrity and anticancer activity of the drug.
In 1994, Chinese university student Zhu Ling began experiencing stomach pain, hair loss and partial paralysis. By the time doctors diagnosed Ling with thallium poisoning about four months later, she was in a coma. Two decades after the poisoning, Richard Ash--an associate research scientist in the University of Maryland's Department of Geology--used mass spectrometry to analyze several of Ling's hairs collected in 1994 and 1995 and established a timeline of her poisoning.
New findings from a team of Marshall University Joan C. Edwards School of Medicine researchers reveal urban and rural differences in prenatal exposure to essential and toxic elements.
Min Dong, PhD, and his lab are world experts in toxins. Now, setting their sights on Shiga toxin (player in the current E. coli outbreak from romaine lettuce) and ricin (a bioterrorism agent), they identify potential protective strategies. Their study also sheds new light on glycosylation, the attachment of sugars to large molecules, key to cells' ability to create more diverse molecules beyond what's encoded in the genome.
Virginia Commonwealth University researchers are testing a vaccine against opioid abuse developed by the Scripps Research Institute in California. The vaccine is meant to block the effects of heroin and fentanyl in patients with opioid use disorder.
Working as part of an international group of toxicologists scientists of the Far Eastern Federal University (FEFU) have found that harmful nanoparticles are formed in the process of arc welding using the most common types of electrodes today. Suspending in the welding fume, these particles infiltrate the human body through the respiratory tract. An article about this is published in Scientific Reports.
New Mexico contains hundreds of historic uranium mines. Although active uranium mining in the state has ceased, rates of cardiovascular and metabolic disease remain high in the population residing close to mines within the Navajo Nation. According to a new study in ACS' journal Environmental Science & Technology Letters, inhaled uranium in dusts from the mines could be a factor.
In the summers of 2017 and 2018, heat waves and drought conditions spawned hundreds of wildfires in the western US and in November, two more devastating wildfires broke out in California, scorching thousands of acres of forest, destroying homes and even claiming lives. Now, researchers studying ash from recent California wildfires report in ACS' Environmental Science & Technology that burned material in forests might help sequester mercury that otherwise would be released into the environment.
Combining low doses of a toxic herbicide with sugar-binding proteins called lectins may trigger Parkinsonism -- symptoms typical of Parkinson's disease like body tremors and slowing of body motions -- after the toxin travels from the stomach to the brain.
New research by environmental scientists at the University of Toronto suggests that the exterior of mobile phones could be a source of toxic chemicals, or at least an aggregate indicator of the chemicals to which people are exposed on a daily basis.