Survivorship care plan improves patient cancer care-related distress levels for hematopoietic cell transplant recipients. Results from a recent multicenter study presented at the American Society of Hematology (ASH) Annual Meeting.
A new method of harvesting stem cells for bone marrow transplantation -- developed by a team of investigators from the Massachusetts General Hospital Cancer Center and the Harvard Stem Cell Institute -- may make the donation process more convenient and less unpleasant for donors while providing cells that are superior to those acquired by current protocols.
The technique, which could be used to transplant donor-matched hematopoietic stem cells (HSCs) or a patient's own genetically-engineered HSCs into the brain, was reported in Science Advances today by researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and the San Raffaele Telethon Institute for Gene Therapy.
The first child to undergo a successful hand transplant also is the first child in whom scientists have detected massive changes in how sensations from the hands are represented in the brain. The brain reorganization is thought to have begun six years before the transplant, when the child had both hands amputated because of a severe infection during infancy. Notably, after he received transplanted hands, the patient's brain reverted toward a more typical pattern.
Researchers report creating a biologically accurate mass-production platform that overcomes major barriers to bioengineering human liver tissues suitable for therapeutic transplant into people. A team led by the Cincinnati Children's Center for Stem Cell and Organoid Medicine (CuSTOM) and Yokohama City University in Japan report their findings Dec. 5 in Cell Reports. The study overcomes what have been nagging challenges for researchers working to bioengineer human organs that are safe and effective for therapeutic use.
This month marks the 50th anniversary of the world's first human heart transplant performed at Groote Schuur Hospital in Cape Town by South African surgeon, Christiaan Barnard. He transplanted the heart of a 25-year-old woman into Louis Washkansky, a 53-year-old diabetes patient who was in severe heart failure. A special issue of The Journal of Heart and Lung Transplantation presents a chronicle of the major milestones in heart transplantation over the last 50 years.
A novel technology developed by researchers at the Massachusetts General Hospital enables the model-ing of human liver transplantation in an experimental setting.
Biliary atresia is the most common cause of liver transplants for children in the United States. Researchers report in Science Translational Medicine finding a strong biomarker candidate that could be used for earlier diagnosis and lifesaving treatments that could avoid more invasive procedures like liver transplant. A research team led by Cincinnati Children's Hospital Medical Center identified molecular markers of the disease in blood samples that accurately diagnosed the condition with greater than 90 percent sensitivity.
A diabetes drug currently undergoing development could be repurposed to help end transplant rejection, without the side-effects of current immunosuppressive drugs, according to new research by Queen Mary University of London.
A type-I collagen derivative with unique properties enables photolithographic bioprinting of 3-D scaffolds.