Researchers at the University of Pittsburgh and the University of Toronto have uncovered the first molecular steps that lead to immune system activation and eventual rejection of a transplanted organ.
Scientists at the Biogerontology Research Foundation, Feinberg School of Medicine at Northwestern University and Swammerdam Institute of Life Sciences at the University of Amsterdam have published a paper on a proposed method of in situ tissue regeneration called Induced Cell Turnover in the journal Human Gene Therapy.
Scientists have discovered that a subset of immune cells called nonclassical monocytes, previously unknown to reside in the lungs, play a key role in driving primary graft dysfunction (PGD), the leading cause of death after lung transplantation. The study demonstrates targeting these cells could lead to novel treatments for PGD, a complication that currently impacts more than half of transplant patients.
A University Hospitals Seidman Cancer Center (UH) study shows TempTraq, a patented, wearable, Bluetooth continuous temperature monitor in the form of a soft, comfortable patch, can detect a rise in body temperature up to 180 minutes earlier, in a majority of patient cases, than the current standard-of-care (SOC) method. Earlier fever detection empowers clinicians to intervene faster. The promising results were published in the Journal of Clinical Oncology.
First study assessing how patients with 'gain of function' mutation of STAT1 gene respond to stem cell transplantation has taken place. It involved 15 young, international, patients. Only six survived transplantation -- with five completely cured. Dr. Okada, who first discovered the mutation, says that, 'Overall, this result is disappointing -- but the fact five patients were cured proves that treatment with stem cells can work, and we now need to learn from these individual cases'.
A new study led by the Research Institute of the McGill University Health Centre revealed that young women had poorer transplant outcomes compared to young men, whereas women of post-menopausal age had similar or slightly better outcomes than men of the same age. This finding opens the door to a new approach for organ transplantation, and could lead to personalized immunosuppression strategies based on age and sex.
A new kidney allocation system implemented in 2014 by the United Network for Organ Sharing (UNOS) led to a narrowing of the disparities in national kidney transplant rates among whites, blacks and Hispanics on the transplant waitlist, according to a new analysis.
Combining a new hydrogel material with a protein that boosts blood vessel growth could improve the success rate for transplanting insulin-producing islet cells into persons with type 1 diabetes. In an animal model, the technique enhanced the survival rate of transplanted insulin-producing cells, restoring insulin production in response to blood glucose levels and curing these diabetic animals.
For some patients undergoing intestinal or multi-organ transplantation, closing the abdominal wall poses a difficult surgical challenge. Total abdominal wall transplantation provides an alternative for abdominal closure in these complex cases, according to a state-of-the-art approach presented in the June issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons.
Patients with hepatitis C who suffer from advanced stages of liver disease have renewed hope, thanks to findings by researchers who have discovered that a new drug significantly reduces their risk of death and need for transplantation.