Findings from continuous glucose monitoring evaluations in islet transplant recipients who have been insulin independent for an average of 10 years show near normal glycemic profiles and time-in-range metrics, demonstrating that islet transplantation can be a successful long-term therapy for select patients with type 1 diabetes.
The confluence of two major health crises -- the opioid epidemic and organ shortage -- has moved surgeons to consider transplanting organs deemed as less than 'perfect' in an effort to expand the donor pool and save more lives, according to research published online today in The Annals of Thoracic Surgery, published by Elsevier.
Preliminary results from a $5.2 million clinical trial led by University of Cincinnati researchers show that the immunosuppressive drug belatacept can help safely and effectively treat kidney transplant patients without the negative long-term side effects of traditional immunosuppressive regimens, the study's leaders announced this week at the annual American Transplant Congress gathering.
In the New England Journal of Medicine, a Brigham team presents the longer-term outcomes for six face transplant recipients who had been followed for up to 5 years after surgery, representing the largest cohort of patients in the US.
Sunnie Thompson's study of BK polyomavirus replication may lead to less failure of kidneys following organ transplant. The virus is silently harbored in most humans; when transplant recipients receive drugs to suppress their immune system to prevent graft rejection, the virus can reactivate and damage the kidney. Thompson's research points to a new way to reduce BK polyomavirus levels in transplant patients without reducing immunosuppressing drugs.
A group of scientists from Russia and Ireland found out how quality of tissue-engineered biomeshes (biological 'frame' which is used for tissue repair) is affected by various chemical fixatives (cross-linkers). Such compounds form chemical 'bridges' between biomesh polymers and change its mechanical and functional properties. It will help to select cross-linkers for treatment of certain transplants. The research results are published in the official journal of the International Xenotransplantation Association.
Piedmont Atlanta Hospital is the first in the state of Georgia to offer a new minimally invasive treatment for emphysema, a severe form of Chronic Obstructive Pulmonary Disease (COPD).
Other than clinical observations, the stem cell field lacks a repeatable, time-sensitive, noninvasive tool to assess the effectiveness of transplanted cells in the targeted organ. Researchers analyzed biomarkers secreted from transplanted human stem cells in the recipient blood of a rodent model of heart attack. Analysis of the blood test showed responding cells had changed their gene expression, behavior and secretions, suggesting this liquid biopsy could provide a window into stem cell activity and effectiveness.
Fecal microbiota transplant (FMT), or the transfer of stool from a healthy donor to a patient, has been found effective in reversing severe, recurring diarrheal infections from Clostridiodes difficile in adults by restoring a normal microbiome. Now, the largest study to date of FMT in children finds the procedure to be safe and effective in eradicating an infection that is on the rise among children, even those without known risk factors.
Up to 1 in 7 kidney donors and recipients may have a type of genetic incompatibility that leads to organ rejection, researchers at Columbia University have found.