The ventrolateral preoptic nucleus (VLPO) in the brain plays a critical role in the initiation and maintenance of sleep, while the lateral posterior part of the hypothalamus contains neuronal populations implicated in maintenance of arousal. Now, a University of Tsukuba-centered study reveals that these arousal-related neurons are heavily innervated by GABAergic neurons in the preoptic area including the VLPO. The work provides important information to understand the mechanisms that control animals' sleep/wakefulness states.
Life-threatening fungal infections affect more than two million people worldwide. Effective antifungal medications are limited. A major challenge is that the fungal cell wall is poorly understood, which has impeded drug development. However, a chemist has identified for the first time the cell wall structure of one of the most prevalent and deadly fungi, which could usher in a new era of antifungal drug development to help save lives.
Scientists at the Mainz University Medical Center and the Max Planck Institute for Polymer Research (MPI-P) have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune cells, which in turn attack tumors.
Winship researchers identified an enzyme responsible for making tumors and cancer cell lines resistant to cisplatin, along with an experimental drug, lestaurtinib, which targets that enzyme.
In a new study that challenges scientists' presuppositions about the carbon cycle, researchers find that tiny organisms may be playing in outside role in the way carbon is circulated throughout the ocean.
A study detected in tumoral tissue hundreds of RNAs that do not encode proteins but appear to regulate effects of androgens and androgen receptors on gene expression in tumors. By investigating the connection between the presençe of these molecules and tumor aggressiveness, the research paves the way for new scientific approaches focusing on the transcription process of noncoding RNA.
Recent articles in the journal Molecular & Cellular Proteomics investigate metabolic quirks of cancer cells, the effects of inhibiting the enzyme that generates amyloid beta, and the mechanism by which a bacterial toxin kills host cells.
Research led by Suresh Alahari, PhD, Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has shown for the first time that a tiny piece of RNA deregulates energy metabolism, an emerging hallmark of cancer. The finding identifies a new target for therapeutic intervention in breast cancer.
Memorization test and non linear EEG analysis could be helpful in identifying subjects at high risk of dementia at the very early stages of cognitive impairment.
An international team of researchers has discovered that bacteria associated to Lagria villosa beetles can produce an antifungal substance very similar to one found in tunicates living in the marine environment. The researchers revealed that this commonality is likely explained by the transfer of genes between unrelated microorganisms.