A new collection of reviews and original research articles illustrate how new technologies and advanced cell culture are accelerating basic research, drug discovery and drug development.
Climate change causes an increase in the number of freshwaters that run dry, at least temporarily. Around 90,000 square kilometres of water surface have already vanished in the last 30 years. This trend is not only a threat to drinking water reserves and major ecosystems - dried freshwaters also play an important role in the global carbon cycle. Two recently published studies reveal that the importance of this phenomenon has so far been underrated.
A KAIST team presents a noninvasive light-sensitive photoactivatable recombinase suitable for genetic manipulation in vivo. The highly light-sensitive property of photoactivatable Flp recombinase will be ideal for controlling genetic manipulation in deep mouse brain regions by illumination with a noninvasive light-emitting diode. This easy-to-use optogenetic module made by Professor Won Do Heo and his team will provide a side-effect free and expandable genetic manipulation tool for neuroscience research.
Heart disease is the greatest killer in the world today. A new study in sheep, publishing Jan. 22 in the open-access journal PLOS Biology, by a team from Cambridge University, finds that offspring whose mothers had a complicated pregnancy may be at greater risk of heart disease in later life, suggesting that our cards may be marked even before we are born.
What happens to sex pheromones as new species emerge? New research publishing Jan. 22 in the open-access journal PLOS Biology studies sex pheromones in the fission yeast Schizosaccharomyces pombe, revealing an 'asymmetric' pheromone recognition system in which one pheromone operates extremely stringently whereas the other pheromone is free to undergo a certain degree of diversification, perhaps leading to a first step towards speciation.
The breakthrough made by researchers at IRB Barcelona allows the study of the role of each molecular component in the stability and conformation of DNA crystals.
Scientists from Tomsk Polytechnic University have developed implants which make mesenchymal stem cell to differentiate into bone tissue and accelerate limb lengthening in two times. The study outcomes were proved during preclinical trials at the Ilizarov Orthopedic Center (Kurgan, Russia).
New research on the US's most economically important agricultural plant -- corn -- has revealed a different internal structure of the plant than previously thought, which can help optimize how corn is converted into ethanol.
Patients with Parkinson's disease are treated with levodopa, which is converted into dopamine, a neurotransmitter in the brain. In a study published on Jan. 18, in the journal Nature Communications, scientists from the University of Groningen show that gut bacteria can metabolize levodopa into dopamine. As dopamine cannot cross the blood-brain barrier, this makes the medication less effective -- even in the presence of inhibitors that should prevent the conversion of levodopa.
How do plants space out their roots? A Japanese research team has identified a peptide and its receptor that help lateral roots to grow with the right spacing. The findings were published on Dec. 20, 2018 in the online edition of Developmental Cell.