Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed medication for major depressive disorder (MDD), yet scientists still do not understand why the treatment does not work in nearly thirty percent of patients with MDD. Now, Salk Institute researchers have discovered differences in growth patterns of neurons of SSRI-resistant patients. The work has implications for depression as well as other psychiatric conditions such as bipolar disorder and schizophrenia that likely also involve abnormalities of the serotonin system in the brain.
A Rice University-led study discovers a mechanism by which molecules affect the plasmonic response of gold nanorods. The mechanism could be used to enhance applications like catalysis that involve plasmon-driven chemistry.
Weeds often emerge at the same time as vulnerable crop seedlings and sneak between plants as crops grow. How do farmers kill them without harming the crops themselves? In a new University of Illinois study, researchers identify genes and metabolic pathways responsible for safener efficacy in grain sorghum.
Superbugs, also known as Gram-negative bacteria, are causing a global health crisis. To combat antibiotic-resistant infections, researchers are pursuing clever new ways to thwart the bacteria's tough defense system. Now, they have uncovered some of the previously unknown machinery that builds the bacterial outer membrane, information that could lead to new treatments for untreatable infections.
The creation of new library of mutants of the single-celled photosynthetic green alga, Chlamydomonas reinhardtii enabled a Carnegie- and Princeton University-led team of plant scientists to identify more than 300 genes that are potentially required for photosynthesis. Photosynthesis is the process by which plants, algae, and some bacteria convert energy from sunlight into carbohydrates -- filling our planet's atmosphere with oxygen as a byproduct.
Chemistry researchers have patented a method for making anti-leukemia compounds that until now have only been available via an Asian tree that produces them.
Magnetic stir bars are regarded as reusable consumables, and in many labs they last for months. This study shows that in a regular catalysis lab almost all magnetic stir bars become permanently contaminated with metal nanoparticles. Regular cleaning procedures do not remove such contamination completely. Indeed, subsequent release of metal traces in the next reactions is unacceptable even in small quantitates. The results of this study are published in ACS Catalysis.
Researchers have engineered nanoscale protein micelles capable of both delivering chemotherapeutic drugs and of being tracked by MRI. The innovation allows researchers to administer therapy while noninvasively monitoring the therapeutic progress and drastically reducing the need for surgical intervention. They biosynthesized a protein block copolymer containing amino acid building blocks with fluorinated thermoresponsive assembled protein (F-TRAP), which assembles into a nanoscale micelle with the noteworthy abilities.
A study by the University of Liverpool reveals new insights into how cells respond to oxygen deprivation. Published in the prestigious journal Science, the researchers found that chromatin, the complex of DNA and proteins where all genes reside, quickly changes in response to low oxygen.
Scientists at the University of Surrey and University College London have revealed an innovative in vitro method that can help to develop easy to swallow medicine for children and older people.