Tokyo Medical and Dental University (TMDU) researchers revealed that RANKL expressed by osteocytes is essential for the bone remodeling during orthodontic tooth movement. This result can facilitate the development of novel therapeutic strategies in orthodontics.
Oregon shore crabs exhibit risky behavior when they're exposed to the antidepressant Prozac, making it easier for predators to catch them, according to a new study from Portland State University (PSU).
A protein shaped like a 'Y' makes scientists do a double-take and may change the way they think about a protein sometimes implicated in glaucoma. The Y is a centerpiece in myocilin, binding four other components nicknamed propellers together like balloons on strings.
A yeast protein that evolved from scratch can fold into a compact three-dimensional shape -- contrary to the general understanding of young proteins. Recent evidence suggests new genes can arise from the non-coding sections, or 'junk,' DNA and that those new genes could code for brand-new proteins. Scientists thought such newly evolved proteins were works-in-progress that could not fold into complex shapes the way more ancient proteins do.
A team of scientists led by Whitehead Institute has uncovered a surprising molecular link that connects how cells regulate growth with how they sense and make available the nutrients required for growth. The researchers' findings also implicate a new protein, SLC38A9, as a potential drug target in pancreatic cancer.
A collaboration between Babraham Institute scientists and AstraZeneca provides new insights into the role of PTEN, a major cancer gene, in controlling cell growth and behaviour. PTEN is the second most commonly altered gene in human cancers, particularly prostate cancers, and this work could help to develop and target new treatments.
Freiburg scientists explain assembly and transport function of 'old' calcium pumps by 'new' partner proteins.
New research shows how a protein is consumed, then reconstituted, during the production of a compound required for converting energy from food into a form that can be used by our cells. The results could help scientists to understand why humans with a fatal condition -- defects in an iron-sulfur carrier gene -- have deficiencies in this lipoic acid compound.
A metallic probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide has identified a binding site that could facilitate better drugs to treat Alzheimer's disease. When the probe is illuminated, it catalyzes oxidation of the protein in a way that might keep it from aggregating in the brains of patients.
Two UA materials science and engineering researchers have experimentally verified the electrochemical processes that control charge transfer rate from an organic polymer to a biomarker molecule. Their findings, reported in Nature Communications, may enhance selectivity for biomarkers in bioelectronic devices.