The internet of things (IoT) is allowing scientists to optimize laboratory operations and combine instruments to measure and respond to complex experimental conditions. As a result, IoT is enabling more detailed and more complex experimental designs.
Imagine your liver being just a big puddle. Some organelles in your cells are exactly that including prominent ones like the nucleolus. Now a synthetic organelle engineered in a lab at Georgia Tech shows how such puddle organs can carry out complex life-sustaining reaction chains.
New 3D maps of water distribution during cellular membrane fusion are accelerating scientific understanding of cell development, which could lead to new treatments for diseases associated with cell fusion. Using neutron diffraction at the Department of Energy's Oak Ridge National Laboratory, researchers have made the first direct observations of water in lipid bilayers used to model cell membrane fusion.
A naturally occurring antibiotic called kanglemycin A is effective against Mycobacterium tuberculosis, the bacteria that cause tuberculosis, even in drug-resistant strains, according to an international team of researchers who used chemistry, molecular biology, microbiology, and X-ray crystallography to show how the compound maintains its activity.
Scientists from The Graduate Center of The City University of New York (GC/CUNY) have made a major breakthrough in chemical synthesis that now makes it possible to quickly and reliably modify the 3D structure of molecules used in drug discovery, according to a paper appearing in the current issue of the journal Science. The new method allows scientists to employ cross-coupling reactions to generate new compounds while controlling their 3D architecture.
Body organs such as the intestine and ovaries undergo structural changes in response to dietary nutrients that can have lasting impacts on metabolism, as well as cancer susceptibility, according to Carnegie's Rebecca Obniski, Matthew Sieber, and Allan Spradling. 'Children born to malnourished mothers often struggle with obesity later in life and our findings could explain the physiology of why that happens,' Obniski explained.
What prevents our cells being damaged due to overexposure to iron ions is a protein called lactoferrin, known for its ability to bind tightly to such ions. In a new study published in EPJ E, Lilia Anghel from the Institute of Chemistry in Chisinau, Republic of Moldova, and research collaborators use combined experimental and molecular dynamics simulationto study the changes in the structure of lactoferrin as it binds to iron ions.
Researchers at University of Tsukuba used a novel approach for analyzing the central nervous system of a proto-vertebrate to identify a regulatory cocktail that induces the creation of dopaminergic neurons/coronet cells, a primitive version of the hypothalamus. The findings shed more light on how neurons differentiate into particular subtypes, with potential implications for the treatment of conditions such as Parkinson's disease.
Stiff microbial films often coat medical devices, household items and infrastructure such as the inside of water supply pipes, and can lead to dangerous infections. Researchers have developed a system that harnesses the power of bubbles to propel tiny particles through the surfaces of these tough films and deliver an antiseptic deathblow to the microbes living inside.
Even tiny amounts of viruses can have disastrous consequences. RNA identification can reveal the type of virus present. A fast and sensitive technique based on optical detection has now been outlined in the journal Angewandte Chemie. Scientists from Germany and Finland have demonstrated the binding of an RNA target to a probe made of gold nanorods and a DNA origami structure. Chirality switches triggered by binding can be measured by circular dichroism spectroscopy.