The human monoamine transporters (hMATs) primary including hSERT, hNET and hDAT are important targets for the treatment of depression and other behavioral disorders with more than the availability of 30 approved drugs.This paper is to review the recent progress in the binding mode and inhibitory mechanism of hMATs inhibitors with the central or allosteric binding sites, for the benefit of future hMATs inhibitor design and discovery.
Synthetic psychoactive drugs have become a serious public health threat in recent years. This is particularly true of the fentanyls, a large family of synthetic opioids, which can be up to 10,000 times more potent than morphine. Synthetic opioids are highly addictive and, because of their potency, often prove fatal: among the roughly 72,000 drug overdose deaths in the US in 2017, some 30,000 were related to synthetic opioids.
Researchers say that changing the legal drink-driving limit without enhancing enforcement and sufficiently publicizing the change does not reduce road traffic accidents.
Researchers from the Virginia Tech School of Neuroscience are teaming with the University of California San Diego and the U.S. National Institutes of Health to develop a drug -- now in its earliest stages -- that can treat certain types of chronic pain without the addictive consequences of opioids.
Antipsychotic medications can have adverse effects, including those that are life-threatening. This observational study examined the association of antipsychotic medications prescribed for children and young adults without psychosis and risk of unexpected death, which includes deaths due to unintentional drug overdose or cardiovascular/metabolic causes. About 250,000 children and young people (ages 5 to 24) enrolled in Medicaid in Tennessee were included.
A study of the Department of Epidemiology and Prevention of I.R.C.C.S. Neuromed (Pozzilli, Italy), in collaboration with the Department of Nutrition of the Harvard T.H. Chan School of Public Health (Boston), highlights that people who consume alcohol moderately (one glass of wine a day), in the general framework of Mediterranean diet principles, have a lower risk of being hospitalized compared to heavier drinkers, but also to the teetotallers.
Aging often improves the flavor of wine, but sometimes the beverage emerges from storage with an unpleasant smell. One of the prime culprits is hydrogen sulfide, which can give the affected wine an aroma of sewage or rotten eggs. In a report in ACS' >Journal of Agricultural and Food Chemistry, researchers have now identified some potential sources of this stinky compound.
Food craving, the intense desire to eat certain foods, can sabotage efforts to maintain healthy eating habits and body weight, no matter the time of year. However, an examination of 28 current peer-reviewed scientific studies largely substantiates findings that changes in diet, prescription medications, physical activity and bariatric surgery reduce craving, said Candice Myers, PhD, assistant professor - research at LSU's Pennington Biomedical Research Center.
Sex workers who face repressive policing are more likely to experience violence and poorer health and well-being, according to new research published in PLOS Medicine.
Dopamine has a reputation as the key player in the brain's reward circuits, making us seek out pleasurable experiences, but growing evidence points to a multipronged role for the neurotransmitter. In particular, dopamine may also reinforce avoidance of painful experiences. UC Berkeley researchers have now mapped dopamine neurons in the brain with fiber photometry and discovered two parallel dopamine circuits driving attractive and aversive reinforcement learning and motivation.