Biochips are driving next-generation DNA sequencing technologies, and this powerful combination is capable of solving unique and important biological problems, such as single-cell, rare-cell or rare-molecule analysis, which next-generation sequencing can't do on its own. In APL Bioengineering, researchers from Seoul National University explore the role advancements in biochip technology are playing in driving groundbreaking scientific discoveries and breakthroughs in medicine via next-generation sequencing, aka high-throughput sequencing.
Researchers have shown for the first time that these insects use different directional sensors to achieve the highest possible navigational precision in different conditions.
The function of protein machines in biological cells is so complex that even supercomputers cannot predict their cycles at atomic detail. But, as demonstrated in this review article, many aspects of their operation at mesoscales can be already revealed by exploring simple mechanical models, amenable for simulations on common computers. The authors also show how artificial protein-like structures with machine properties can be designed.
Inspired by ideas from the physics of phase transitions and polymer physics, researchers in the Divisions of Physical and Biological Sciences at UC San Diego set out to determine the organization of DNA inside the nucleus of a living cell. Their findings, recently published in Nature Communications, suggest that the phase state of the genomic DNA is 'just right' -- a gel poised at the phase boundary between gel and sol, the solid-liquid phase transition.
Photoreceptor cells in our eyes can adjust to both weak and strong light levels, but we still don't know exactly how they do it. Emeritus Professor Fumio Hayashi of Kobe University and his colleagues revealed that the photoreceptor protein rhodopsin forms transient clusters within the disc membranes in retina. These clusters are concentrated in the center of disc membranes, and act as platforms in the process of light to chemical signal conversion.
A new wearable technology, developed by engineers at the University of Texas at Austin, that is made from stretchy, lightweight material, could make heart health monitoring easier and more accurate.
Researchers at the University of Bath have developed a new way of designing and manufacturing bespoke prosthetic liners, in less than a day.
Modesto Orozco's lab (IRB Barcelona) has published a study on the reaction mechanism of DNAzymes in Nature Catalysis. DNAzymes, which are catalysers formed by DNA, have applications in biomedicine and biotechnology. These research results will contribute to advances in the design and improvement of catalysers for therapeutic purposes.
A team of researchers has developed a new technique for mapping cells. The approach, called DNA microscopy, shows how biomolecules such as DNA and RNA are organized in cells and tissues, revealing spatial and molecular information that is not easily accessible through other microscopy methods. DNA microscopy also does not require specialized equipment, enabling large numbers of samples to be processed simultaneously.
This partnership will employ Shimmer's Verisense™ wearable sensors platform, which has been designed specifically for use in clinical research, with ClearSky algorithms and machine learning to transform wearables data into actionable insights for central nervous system (CNS) diseases.