New research provides mechanistic insight into how protein dynamics control the activity of a group of enzymes called serine proteases. As serine proteases play pivotal roles in blood coagulation, the innate immune system and tissue remodeling, the results may be important for the development of new drugs for the treatment of various diseases.
Yoga causes musculoskeletal pain in 10 percent of people and exacerbates 21 percent of existing injuries, University of Sydney research shows. Published in the Journal of Bodywork and Movement Therapies, the findings come from the first prospective study to investigate injuries caused from recreational participation in yoga. The injury rate is up to 10 times higher than has previously been reported.
St. Jude Children's Research Hospital discovery of the mechanism of T cell exhaustion will lead to treatments to enhance immunotherapies against cancers and such viruses as HIV.
A collaborative study led by Dr. BI Guoqiang at University of Science and Technology of China of Chinese Academy of Sciences and Dr. CHENG Heping at Peking University (PKU) revealed the essential role of dendritic mitochondrial flash in transforming short-term synaptic plasticity into long-term plasticity.
For years, anecdotes and some studies have suggested that chimpanzees are 'super strong' compared to humans, implying that their muscle fibers are superior to humans'. Now a research team including a UMass Amherst kinesiologist reports that contrary to this belief, chimp muscles' maximum dynamic force and power output is just about 1.35 times higher than human muscle of similar size, a difference they call 'modest' compared with historical, popular accounts of chimp 'super strength,' being many times stronger than humans.
Carbon nanotubes exhibit interesting characteristics rendering them particularly suited to the construction of special hybrid devices -- consisting of biological issue and synthetic material -- planned to re-establish connections between nerve cells, for instance at spinal level, lost on account of lesions or trauma. This is the result of a piece of research published on the scientific journal Nanomedicine: Nanotechnology, Biology, and Medicine.
A research group of Tokyo University of Agriculture and Technology, Tokyo Institute of Technology, Keio University and Tohoku University have successfully developed an artificial cytoskeletal structure for cell models (liposomes or artificial cells) using DNA nanotechnology, and demonstrated that liposomes with the cytoskeletal structure were almost as strong as living cells.
EPFL scientists show how some pathogenic bacteria -- such as the mycobacteria that cause tuberculosis -- use a previously unknown mechanism to coordinate their division. The discovery could help develop new ways to fight them.
Tetanus toxin is the neurotoxin that causes lockjaw. Many are vaccinated, but tetanus still kills tens of thousands of people per year worldwide. Researchers from the Department of Biochemistry and Biophysics, led by Dr. Pål Stenmark, have now uncovered the poison's structure. For the first time, the way the poison is constructed has been revealed.
Ultrasound is commonly used in diagnostic imaging of the body's soft tissues, including muscles, joints, tendons and internal organs. A technology called high-intensity focused ultrasound is also being explored for therapeutic uses including the removal of uterine fibroids and the destruction of tumors. A suite of noninvasive, adaptive focusing techniques -- that allow ultrasonic beams to be focused through the rib cage and skull -- will be described during Acoustics '17 Boston.