Research in mouse cells identifies defective metabolic pathway in aging immune T cells. The pathway is critical for switching T cells from dormancy into illness-fighting mode. In experiments, researchers restored lagging T-cell function by adding small-molecule compounds. Findings suggest possible mechanism behind weakened immunity common in the elderly.
- Proceedings of the National Academy of Sciences
- F. Hoffmann-La Roche, Glenn Foundation for Medical Research, National Institutes of Health, EMBO (European Molecular Biology Organization)