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Scientists of Far Eastern Federal University (FEFU) and the G.B. Elyakov Pacific Institute of Bioorganic Chemistry (FEB RAS) together with German colleagues spotted six new and three already known biologically active compounds in a new strain of the fungus Penicillium piltunense first time isolated. One compound has a pronounced anti-inflammatory activity, others have herbicidal potential, i.e., possibly, can become components of new chemicals for weed control. A related study is published in Marine Drugs.
Summary: - St. John's Wort Hypericum perforatum is an ancient medicinal plant. It is known for the mild antidepressant properties of its bioactive compound hypericin, which is produced in the dark glands of the plant. - By investigating the flowers of St. John's Wort, researchers identified genes involved in dark gland development and the biosynthesis of hypericin. - The findings were published in the Plant Biotechnology Journal.
Kyoto University research shows that Purkinje cell dendrites filter out signals to the Soma. Distal dendrites modulate the incoming signals through intrinsic plasticity associated with the down-regulation of SK channels
Harvard Wyss Institute researchers developed a living material approach that uses a strain of genetically engineered E.coli Nissle bacteria as a locally acting probiotic. The engineered bacteria produce a network of nanofibers that directly binds to mucus to fill inflamed areas like a patch, shielding them from gut microbes and environmental factors. This probiotic-based therapeutic strategy protected mice against the effects of colitis induced by a chemical agent and promoted mucosal healing.
Amidst rising hopes for using CRISPR gene editing tools to repair deadly mutations linked to conditions like cystic fibrosis and sickle cell disease, a new study in the Nature journal Communications Biology describes a new innovation that could accelerate this work by rapidly revealing unintended and potentially harmful changes introduced by a gene editing process.
Nanopipettes with zwitterionic membranes may offer improved monitoring of changes in pH surrounding living cells, which can indicate traits of invasive cancer cells and their response to treatment, report researchers at Kanazawa University in Nature Communications.
Scientists in Korea find a protein that mediates the interaction between the cellular systems involved in rapid responses against foreign genes in plants.
Researchers at UT have developed a free open source computer program that can be used to create visual and quantitative representations of brain electrical activity in laboratory animals in hopes of developing countermeasures for opioid use disorder.
Recycling biotechnology byproducts can enhance soil health while reducing carbon emissions and maintaining crop yields.
Protocells -- artificial cells -- that are active and mimic living cells by moving independently and that are biocompatible and enzymatically active are now possible using an improved method developed by Penn State researchers.