In new studies conducted at UC San Francisco, a novel oxygen-delivery therapeutic restored the function of oxygen-starved heart tissue in an animal model of global hypoxia. Unlike its experimental predecessors, the new drug does not appear to cause systemic side effects or overcorrect with excessive blood oxygenation, which can itself be toxic. Instead, the new drug delivers its precious oxygen cargo only to the tissues that need it most.
Microorganisms often assemble natural products similar to industrial assembly lines. Certain enzymes, non-ribosomal peptide synthetases (NRPS) play a key role in this process. Biotechnologists at Goethe University have now been able to discover how these enzymes interact with each other. This brings them one step closer to their goal of engineering the production of such peptide natural products.
Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and the Stein Eye Institute have been awarded a $5.1 million grant from the California Institute for Regenerative Medicine to advance the development of a novel therapy for blinding retinal conditions.
Girls who play video games are three times more likely to choose physical science, technology, engineering or maths (PSTEM) degrees compared to their non-gaming counterparts, according to new research from the University of Surrey.
Researchers have for the first time been able to investigate the abundance and methyl modifications of all mitochondrial tRNAs in patients suffering from one of the most common inherited mitochondrial tRNA mutations. The analysis pipeline revealed quantitative changes that had dramatic effects on protein synthesis within mitochondria.
Personal electronic devices are a growing source of the world's electronic waste. Many of these products use nanomaterials, but little is known about how nanoparticles interact with the environment. Now a research team including Northwestern University chemists has discovered that when certain coated nanoparticles interact with living organisms it results in new properties that cause the nanoparticles to become sticky. Nanoparticles with 5-nanometer diameters form long kelp-like structures that are microns in size. The impact on cells is not known.
Bacteria and Archaea have developed many types of CRISPR-Cas systems to protect themselves from viruses. A search through metagenomic databases of microbes, many of them uncultivatable, unearthed the genes of the smallest known working Cas complex, Cas14, from the genome of a DPANN Archaea, a group of microbes with the smallest known geomes. Cas14 is being incorporated into a CRISPR diagnostic called DETECTR.
A new molecular engineering technique has the potential to double the number of light-sensitive proteins available for studying brain circuits.
A study led by Chalmers University of Technology, Sweden, has shown that carbon fibers can work as battery electrodes, storing energy directly. This opens up new opportunities for structural batteries, where the carbon fiber becomes part of the energy system. The use of this type of multifunctional material can contribute to a significant weight-reduction in the aircraft and vehicles of the future -- a key challenge for electrification.
A team of researchers has developed three-dimensional (3D) human tissue culture models for the central nervous system that mimic structural and functional features of the brain and demonstrate neural activity sustained over a period of many months. With the ability to populate a 3D matrix of silk protein and collagen with cells from patients with Alzheimer's disease, Parkinson's disease, and other conditions, the tissue models allow for the exploration of cell interactions, disease and response to treatment