Researchers tracked genomic alterations detected in patient samples during tumor cell evolution in culture, in patient-derived xenograft (PDX) mouse models from the cultures, as well as before and after treatment in patients. In a recent paper in Nature Genetics, the team reports that tumor progression was often driven by cancer-promoting genes, known as oncogenes, on extrachromosomal pieces of DNA.
From energy materials to disease diagnostics, new microscopy techniques can provide more nuanced insight. Researchers first need to understand the effects of radiation on samples, which is possible with a new device developed for holding tightly sealed liquid cell samples for transmission electron microscopy.
Using new technologies to track how vision guides foot placement, researchers at the University of Texas at Austin come one step closer in determining what is going on in the brain while we walk, paving the way for better treatment for mobility impairments -- strokes, aging and Parkinson's -- and technology development -- prosthetics and robots.
A team led by Columbia University Biomedical Engineering Professor Gordana Vunjak-Novakovic has designed a creative new approach to help injured hearts regenerate by applying extracellular vesicles secreted by cardiomyocytes rather than implanting the cells. The study shows that the cardiomyocytes derived from human pluripotent stem cells (derived in turn from a small sample of blood) could be a powerful, untapped source of therapeutic microvesicles that could lead to safe and effective treatments of damaged hearts.
Europe's ash dieback epidemic could well have been caused by just one or two mushroom-like fruiting bodies of a fungal pathogen from Asia, according to a comprehensive genome sequencing effort published in Nature Ecology & Evolution. This leaves even the most resistant ash trees at threat from the introduction of just one more spore from East Asia.
A new method has been developed to make drugs 'smarter' using nanotechnology so pharmacologists can tailor their drugs to more accurately target an area on the body, such as a cancer tumor.
A team of Russian scientists together with foreign colleagues found out that the venom of crab spider Heriaeus melloteei may be used as a basis for developing treatment against hypokalemic periodic paralysis.
Need stronger timber, better biofuels or new sources of green chemicals? A systems biology model developed over decades of research led by NC State University will accelerate progress in engineering trees for specific needs.
An international team of researchers led by professor Niklas Arnberg at Umeå University, shows that adenovirus binds to a specific type of carbohydrate that is overexpressed on certain types of cancer cells. The discovery opens up new opportunities for the development of virus-based cancer therapy. The study is published in the latest issue of the scientific journal Proceedings of the National Academy of Sciences.
Often people think performing in front of others will make them mess up, but a new study found the opposite: being watched makes people do better.