University of Pittsburgh Associate Professor John A. Keith is using new quantum chemistry computing procedures to categorize hypothetical electrocatalysts that are "too slow" or "too expensive", far more thoroughly and quickly than was considered possible a few years ago.
Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo elucidated why arrhythmia occurs post-transplant of hESC-CMs.
Testing chemical compounds for their ability to cause cancer is one way in which scientists can identify hazardous chemicals and thereby protect public health. But, standard testing methods are usually complex and time-consuming. In a new paper published in Scientific Reports, scientists have described a novel testing method based on stem cells that may allow scientists to quickly assess large numbers of compounds for their carcinogenicity.
A new computational tool developed by researchers from Purdue University and MIT could help better determine which drugs should move from animal testing to humans. It could also sooner detect a reason why a drug might fail, guiding how a clinical trial should be set up.
A University of Houston College of Medicine researcher has found how a protein inside the body reduces the adverse effects of hypertonicity, an imbalance of water and solutes inside cells, which leads to cell death.
Biomedical engineers at Duke University have shown that different strains of the same bacterial pathogen can be distinguished by a machine learning analysis of their growth dynamics alone, which can then also accurately predict other traits such as resistance to antibiotics. The demonstration could point to methods for identifying diseases and predicting their behaviors that are faster, simpler, less expensive and more accurate than current standard techniques.
Biomedical engineers at Duke University have demonstrated a method for controlling the phase separation of an emerging class of proteins to create artificial membrane-less organelles within human cells. The advance, similar to controlling how vinegar forms droplets within oil, creates opportunities for engineering synthetic structures to modulate existing cell functions or create entirely new behaviors within cells.
The agglomeration of proteins into structures called amyloid plaques is a common feature of many neurodegenerative diseases, including Alzheimer's. Now, scientists reveal, through experiments and simulations, how resonance with an infrared laser, when it is tuned to a specific frequency, causes amyloid fibrils to disintegrate from the inside out. Their findings open doors to novel therapeutic possibilities for amyloid plaque-related neurodegenerative diseases that have thus far been incurable.
Scientists from Nanyang Technological University, Singapore (NTU Singapore) and the Agency for Science, Technology and Research (A*STAR) have showed that applying "temporal pressure" to the skin of mice can create a new way to deliver drugs.
The mechanism unveiled triggers a mutation fog, causing hundreds of mutations in each tumor, which spread through the genome of lung, head-and-neck and breast cancers. Researchers from the Genome Data Science Lab have identified the antiviral APOBEC3A enzyme as the major cause of this new type of hypermutation. Published in Nature Genetics, the study shows how the mutation fog process generates many oncogenic "cancer driver" mutations, thus accelerating tumour development.