Researchers in Japan have revealed that DNA methylation occurs in the serotonin transporter gene that regulates neurotransmitter transmission in schizophrenia and bipolar patients. Particularly prominent in males and patients with certain genetic polymorphisms, this methylation is inversely correlated to amygdala volume. This work is expected to lead to a better understanding of the pathophysiology of schizophrenia and bipolar disorder. It may also help to develop therapeutic agents and diagnostic/therapeutic markers that target epigenetic conditions.
- Schizophrenia Bulletin
- 1) Japan Society for the Promotion of Science (JSPS) KAKENHI, 2) Japan Science and Technology Agency (JST), 3) Japan Agency for Medical Research and Development (AMED)