A team of researchers in Japan developed a synthetic molecular code to script gene activation. The process, described in the Journal of the American Chemical Society, could help lead to future gene-based therapies for a wide array of diseases.
When cells become stressed, they activate specific response patterns. Würzburg researchers have identified new details of these responses, which can help to get a better understanding of neurodegenerative diseases.
Hematopoietic Stem Cells (HSCs) give rise to blood and immune cells of the body, and are therefore essential for our survival. The group of Manuela Baccarini at the Max F. Perutz Laboratories, a joint venture of the University of Vienna and the Medical University of Vienna, has now shown how intracellular signalling can safeguard this delicate balance between activation and dormancy. Their results are published in the prominent journal Cell Stem Cell.
University of Cordoba researchers manage to reduce oxidative stress brought about by this well-known pesticide in mice via a selenium-enriched diet.
Some cancers express unusually high levels of a neural calcium channel known as the 'wasabi receptor,' which plays a role in detecting pain, cold and other sensations. New research finds cancer cells co-opt this neural channel to increase their tolerance against toxic oxidative stress. Blocking the activity of this channel in mice curbs tumor growth and makes cancer cells more sensitive to chemotherapy.
p38 blockage has been shown to increase the death of tumor cells, thus causing tumors to shrink. The combination of p38 inhibitors with chemotherapeutic drugs (taxanes) strengthens, accelerates or prolongs the antitumor effect in patient-derived tumors grown in mice.
Researchers at the University of Michigan Rogel Cancer Center have discovered that tumor cells reprogram metabolic pathways to gain control over a type of immune cell that allows cancer growth.
The question of the origin of life remains one of the oldest unanswered scientific questions. A team at the Technical University of Munich (TUM) has now shown for the first time that phase separation is an extremely efficient way of controlling the selection of chemical building blocks and providing advantages to certain molecules.
Previous studies have found an association between two commonly used agrochemicals (paraquat and maneb) and Parkinson's disease. Now U of G professor Scott Ryan has determined that low-level exposure to the pesticides disrupts cells in a way that mimics the effects of mutations known to cause Parkinson's disease. Adding the effects of the chemicals to a predisposition for Parkinson's disease drastically increases the risk of disease onset.
Antimicrobial resistance (AMR) is a major medical problem worldwide, impacting both human health and economic well-being. A new strategy for fighting bacteria has now been reported in the latest online issue of Nature by a research group headed by Professor Ivan Dikic at the Goethe University Frankfurt. The scientists revealed the molecular action mechanism of a Legionella toxin and developed a first inhibitor.