Cells made by fusing a normal human muscle cell with a muscle cell from a person with Duchenne muscular dystrophy -- a rare but fatal form of muscular dystrophy -- were able to significantly improve muscle function when implanted into the muscles of a mouse model of the disease.
A Syracuse University engineering team has developed a process that combines biomaterials-based cell patterning and stem cell technology to make a 3-D tissue model that could mimic early stage human heart development. Embryotoxicity is just one potential use of the modeling platform.
Researchers have demonstrated how auxin, a hormone that controls many processes in plants, reaches its destination.
The International Journal of Cancer has just published the results of an experimental therapy tested on mice. The research, led by the Signaling Lab research group of the UPV/EHU's Faculty of Medicine and Pharmacy and the Department of Pharmacology, Pharmacy and Pharmaceutical Technology of the University of Santiago de Compostela, achieved an 80 percent reduction in liver metastasis brought about by colon cancer.
Researchers at the University of Washington and the Allen Institute for Brain Science have developed a new method to classify and track the multitude of cells in a tissue sample. In a paper published March 15 in the journal Science, the team reports that this new approach -- known as SPLiT-seq -- reliably tracks gene activity in a tissue down to the level of single cells.
Neuroscientists at the Sainsbury Wellcome Centre have identified a circuit in the primary visual cortex (V1) of the brain that integrates head- and visual-motion signals. The study, published today in Neuron, elucidates the mechanisms by which visual and vestibular inputs to the brain sum together to enable appropriate behavioural responses.
Inhibitory interneurons are particularly important for managing brain rhythms. They're also the research focus of a laboratory led by Jorge Palop, Ph.D., assistant investigator at the Gladstone Institutes. In a study published in Neuron, Palop and his collaborators uncovered the therapeutic benefits of genetically improving these interneurons and transplanting them into the brain of a mouse model of Alzheimer's disease.
The gateway to cellular headquarters has 552 components. A new map that shows how all these pieces fit together could help scientists study numerous diseases.
While the behavior of blood cells flowing within single, straight vessels is a well-known problem, less is known about the individual cellular-scale events giving rise to blood behavior in microvascular networks. To better understand this, researchers Peter Balogh and Prosenjit Bagchi published a recent study in the Biophysical Journal.
The Piezo1 and Piezo2 ion channels are known to open up response to the slightest mechanical stimulus. MDC researchers have now discovered that the channels are also sensitive to changes in membrane voltage. The voltage sensitivity appears to be an ancient property of these channels that protects cells from mechanical stress.