Researchers have reversed wrinkled skin and hair loss, hallmarks of aging, in a mouse model. When a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and extensive, visible hair loss in a matter of weeks. When the mitochondrial function is restored by turning off the gene responsible for mitochondrial dysfunction, the mouse returns to smooth skin and thick fur, indistinguishable from a healthy mouse of the same age.
In the lab it was possible to improve the symptoms in the chronic phase of the disease while encouraging the repair of the nervous tissue, and the challenge now is to move the research forward in humans. This discovery is the outcome of the work by an international consortium led in the Basque Autonomous Community by the UPV/EHU and the Achucarro centre together with personnel from ciberNed and CICbiomaGUNE.
This is a nice example of a rather unexpected discovery: by studying the development of the blood vessels of the brain, researchers at Université libre de Bruxelles have just shed light on a question that was pending for 10 years! They provide a molecular mechanism conferring ligand specificity to Wnt signaling, an ancestral communication pathway present in all vertebrates. Their research is published in Science.
Scientists at the Mainz University Medical Center and the Max Planck Institute for Polymer Research (MPI-P) have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune cells, which in turn attack tumors.
Genome research conducted by the University of Warwick suggests that enteric fever, a potentially lethal disease more commonly found in hot countries, was present in medieval Europe. Salmonella Paratyphi C causes enteric fever, a life-threatening infection, and has been detected in a 800 year old human skeleton discovered in Trondheim, Norway.
An international group of researchers have raised the viability of mice that were cloned using a method called somatic cell nuclear transfer, by stimulating two epigenetic factors, and by doing this have shown that creating cloned animals more efficiently will require further work in the area of epigenetics. They have also uncovered a key epigenetic mechanism that appears to be a major impediment to the development of the fetus after implantation.
Winship researchers identified an enzyme responsible for making tumors and cancer cell lines resistant to cisplatin, along with an experimental drug, lestaurtinib, which targets that enzyme.
Virus particles that infect bacteria can work together to overcome antiviral defences, new research shows.
A paper published today in Nature Communications explains how researchers at the Advanced Science Research Center (ASRC) at The Graduate Center of The City University of New York have uncovered the role of a protein known as 'PRMT5' in the production of myelin and, ultimately, proper development and function of the Central Nervous System.
Fruit flies from different species can warn each other when parasitic wasps are near. But according to a new study led by Balint Z. Kacsoh of Geisel School of Medicine at Dartmouth, published July 19th in PLOS Genetics, they are more likely to get the message across if the fly species have previously cohabited and learned each other's dialects.