News by Subject Technology & Engineering

A compound effective in killing chemotherapy-resistant glioblastoma-initiating cells (GICs) has been identified, raising hopes of producing drugs capable of eradicating refractory tumors with low toxicity.

Researchers at UC Santa Cruz have developed ultrasensitive nanoscale optical probes to monitor the bioelectric activity of neurons and other excitable cells. This novel readout technology could enable scientists to study how neural circuits function at an unprecedented scale by monitoring large numbers of individual neurons simultaneously. It could also lead to high-bandwidth brain-machine interfaces with dramatically enhanced precision and functionality.

In an open-source research paper, a UVA Engineering professor and her former Ph.D. student share a new, more accurate method for modeling evolutionary change.

Medical University of South Carolina researchers report in Nature Communications they have obtained 3D structural snapshots of Cdc34 in action. Cdc34 is an enzyme important for cell cycle regulation and a target for therapeutic intervention in cancer. These structures, along with studies in human cells, have revealed key features of this enzyme important for its regulation of cell growth and activity. These unique features could present opportunities for rational design of novel cancer therapeutics.

Synthetic bone substitutes are promising materials for bone defect repair, but their efficacy can be substantially improved by bioactive agents such as growth factors.

The once-rare 'fabella' bone has made a dramatic resurgence in human knees, but who's likely to have a fabella or two -- and why?

Women receive poorer heart attack treatment than men, even when rates of diagnosis are the same, according to new research funded by the British Heart Foundation (BHF) and published in the Journal of the American College of Cardiology.