In a recent paper published in Nature Communications, University of Illinois professor Andrew Smith reported the invention of a new technology platform that digitally counts, for the first time ever, the amount of growth factor entering an individual cell. Prior to this, researchers inferred growth factor binding based on how the receiving cells responded when the growth factor molecules were introduced.
Wake Forest Institute for Regenerative Medicine scientists have figured out a better way to deliver a DNA editing tool to shorten the presence of the editor proteins in the cells in what they describe as a 'hit and run' approach.
CRG investigators develop a technique to identify and classify proteins with less than 100 amino acids. These types of proteins account for only 16 percent of a bacterial genome's coding capacity. This technique may be applied to guide the search for new proteins with different functions, such as antimicrobials.
MIT researchers have developed an MRI-based calcium sensor that allows them to peer deep into the brain. Using this technique, they can track electrical activity inside the neurons of living animals, enabling them to link neural activity with specific behaviors.
The efficiency of CRISPR genome editing tools targeted to the site of interest by Cas9 nucleases varies considerably and a new CMP-fusion strategy, called CRISPR-chrom, enhances the activity up to several-fold.
LSU mechanical engineering graduate student Tatiana Mello of Piracicaba, Brazil, is currently working on genetically engineering and optimizing E. coli bacteria to produce bioproducts, like biodiesel, in a cost-effective manner.
Euglena cells are unicellular organisms that spend most of their time on swimming by beating their flagellum. Sometimes, Euglena performs harmoniously coordinated cell body deformation, in a behavior known as metaboly. A team of researchers from SISSA and OGS in Trieste, Scuola Superiore Sant'Anna in Pisa, and UPC in Barcelona shows that metaboly allows Euglena to crawl remarkably fast in narrow spaces. This feature could inspire new applications in soft robotics.
The CRISPR Journal announces the publication of its February 2019 issue. The Journal is dedicated to validating and publishing outstanding research and commentary on all aspects of CRISPR and gene editing, including CRISPR biology, technology and genome editing, and commentary and debate of key policy, regulatory, and ethical issues affecting the field.
The remarkable properties of a recently-discovered squid protein could revolutionize materials in a way that would be unattainable with conventional plastic. Originating in the ringed teeth of a squid's predatory arms, this protein can be processed into fibers and films with applications ranging from health-monitoring 'smart' clothes to self-healing recyclable fabrics that reduce microplastic pollution. Materials made from this protein are eco-friendly and biodegradable, with sustainable large-scale production achieved using laboratory culture methods.
Previous studies have shown that estrogens and estrogen-like compounds reduce multiple sclerosis-like inflammation and disability in mice. At first glance these treatments appear promising, but they carry a host of negative side effects, from feminizing male mice to increasing the risk of cancer, heart disease and stroke. An interdisciplinary team of scientists have piggy-backed on this approach with a new concept that side steps the negative side effects while alleviating symptoms.