Researchers at Texas A&M University are pushing organ-on-a-chip devices to new levels that could change the way clinicians approach cancer treatment, particularly ovarian cancer. A team has recently submitted a patent disclosure with the Texas A&M Engineering Experiment Station.
A new optogenetic tool, a protein that can be controlled by light, has been characterized by researchers at Ruhr-Universität Bochum. They used an opsin - a protein that occurs in the brain and eyes - from zebrafish and introduced it into the brain of mice. Unlike other optogenetic tools, this opsin is not switched on but rather switched off by light. Experiments also showed that the tool could be suitable for investigating changes in the brain that are responsible for the development of epilepsy.
After gaining world attention by 'unboiling' egg protein, Flinders University scientists have now used an Australian-made novel thin film microfluidic device to manipulate Beta-lactoglobulin (β-lactoglobulin), the major whey protein in cow's, sheep's and other mammals. In the latest application, published in Molecules, College of Science and Engineering experts have combined the capabilities of the VFD with a new form of biosensor called TPE-MI, which is an aggregation-induced emission luminogen (AIEgen).
Researchers at Aalto University have used lignin, a natural polymer abundant in wood and other plant sources, to create a safe, low-cost and high-performing coating for use in construction. As there is a global urge to meet the rising sustainability standards, this new coating has great potential to protect wood, whose use in construction is continually increasing. The new coating is non-toxic, hydrofobic, it retains wood's breathability and natural roughness while being resistant to colour changes and abrasion.
Synlogic, Inc. announced today the publication of two papers in the journals Nature Metabolism and Communications Biology.
A new tool that enables thousands of tiny experiments to run simultaneously on a single polymer chip will let scientists study enzymes faster and more comprehensively than ever before.
The touchscreen technology used in billions of smartphones and tablets could also be used as a powerful sensor, without the need for any modifications.
An innovative testing platform that more closely mimics what cancer encounters in the body may allow for more precise, personalized therapies by enabling the rapid study of multiple therapeutic combinations against tumor cells. The platform, which uses a three-dimensional environment to more closely mirror a tumor microenvironment, is demonstrated in research published in Communications Biology.
A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, two dimeric subcomplexes are formed, which independently exit the ER and only afterwards assemble into a four-subunit complex. This 'buckle up' mechanism is thought to prevent premature assembly and activity.
DeepMind is partnering with EMBL to make the most complete and accurate database yet of the predicted human protein structures freely and openly available to the scientific community The AlphaFold Protein Structure Database will enable research that advances understanding of these building blocks of life, accelerating research across a variety of fields. AlphaFold's impact is already being realised by early partners researching neglected diseases, studying antibiotic resistance, and recycling single-use plastics.