IBS scientists developed a new faster and more efficient optogenetic tool to manipulate protein clusters under blue light.
It's a tiny marine invertebrate, no more than 3 millimeters in size. But closely related to humans, Botryllus schlosseri might hold the key to new treatments for cancer and a host of vascular diseases.
Exosomes - tiny biological nanoparticles which transfer information between cells - offer significant potential in detecting and treating disease, the most comprehensive overview so far of research in the field has concluded. Areas which could benefit include cancer treatment and regenerative medicine.
Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to research published June 22 in Cell Stem Cell. The study is believed to be the first time human colon organoids have been successfully tissue engineered in this manner, according to researchers who led the project.
A new paper describes the objective and effective use of I-Portal® technology to test and monitor mTBI patients over time. The authors conclude the testing paradigm will allow investigators to institute better treatments and provide more accurate return to activity advice. Six measures from five tests were found to classify the control and mTBI patients with extremely high sensitivity and specificity.
When it comes to testing for cancer, environmental pollution and food contaminants, traditional sensors can help. The challenges are that they often are bulky, expensive, non-intuitive and complicated. Now, one team reports in ACS Sensors that portable pressure-based detectors coupled with smartphone software could provide a simpler, more affordable alternative while still maintaining sensitivity.
Today, tracking the development of individual cells and spotting the associated factors under the microscope is nothing unusual. However, impairments like shadows or changes in the background complicate the interpretation of data. Now, researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München have developed a software that corrects images to make hitherto hidden development steps visible.
A team from Harvard's Wyss Institute for Biologically Inspired Engineering, the LMU Munich, and the Max Planck Institute of Biochemistry in Germany, has engineered highly versatile metafluorophores by integrating commonly used small fluorescent probes into self-folding DNA structures where their colors and brightness can be digitally programmed. This nanotechnological approach offers a palette of 124 virtual colors for microscopic imaging.
Researchers have developed a two-pronged approach to blood cancer treatment: 1) attacking cancer cells directly and/or 2) driving them from the nurturing bone marrow environment into the peripheral blood streams, where they are more vulnerable (for example, to chemotherapy).
A team of scientists from the VIB lab of Han Remaut (VIB-VUB) and the lab of Yves Dufrêne at UCL Louvain-La-Neuve collaborated on a study of functional amyloids -- protein aggregates with the typical amyloid structure that do not lead to disease but rather serve a dedicated biological function.