Microscopes enhanced with artificial intelligence (AI) could help clinical microbiologists diagnose potentially deadly blood infections and improve patients' odds of survival, according to microbiologists at Beth Israel Deaconess Medical Center (BIDMC).
Researchers at the Medical University of South Carolina have identified a signaling pathway regulating cell migration and metastasis. Unexpected hair loss in a preclinical model helped them to identify the pathway. When cells within the skin that maintain hair follicles migrate too often, hair follicle maintenance is disrupted. Researchers speculated that this pathway might also play a role in cancer cell migration. Indeed, they showed that disrupting this pathway in preclinical models increased metastasis.
In a research article '3D Nano-scale Imaging by Plasmonic Brownian Microscopy' published today in Nanophotonics, the team around Prof. Xiang Zhang from the University of California in Berkeley demonstrate a method for meeting this challenge with stunning properties.
A KAIST research team led by Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering developed technology to find the optimum drug target according to the type of cancer cell. The team used systems biology to analyze molecular network dynamics that reflect genetic mutations in cancer cells and to predict drug response. The technology could contribute greatly to future anti-cancer drug development.
UT researchers successfully constructed a first-of-its-kind chemical oscillator that uses DNA components. DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Recently developed computational strategies could help realize the promise of peptide-based drugs. Researchers were able to sample the diverse landscape of shapes that peptides can form as a guide for designing the next generation of stable, potent, selective drugs. They compiled a library of peptide scaffolds upon which drug candidates might be designed. Their methods also can be used to design additional custom peptides with arbitrary shapes on demand.
A novel approach published in Science by a collaborative team of researchers from the Wyss Institute, Arizona State University, and Autodesk for the first time enables the design of complex single-stranded DNA and RNA origami that can autonomously fold into diverse, stable, user-defined structures.
Cornell University engineers have demonstrated a method for gathering blood pressure, heart rate and breath rate using a cheap and covert system of radio-frequency signals and microchip 'tags,' similar to the anti-theft tags department stores place on clothing and electronics.
The interaction of protein shell and active centre in hydrogen-producing enzymes is crucial for the efficiency of biocatalysts. A team from Ruhr-Universität Bochum and the Max Planck Institute for Chemical Energy Conversion in Mülheim an der Ruhr specifically analysed the role of hydrogen bonds in certain enzymes from green algae, the hydrogenases. The groups, which cooperate in the Excellence Cluster Resolv, reported the results in the Journal of the American Chemical Society.
QUT robotics researchers have developed new technology to equip underground mining vehicles to navigate autonomously through dust, camera blur and bad lighting.