Now, researchers have shown that it is possible to evoke a shift in the metabolism from fermentation to respiration of E. coli and baker's yeast by optimizing fermentation conditions. This shift means that the cells can be pushed into producing more internal energy (ATP).
An international group of scientists studied the effects of 17 different lifespan-extending interventions on gene activity in mice and discovered genetic biomarkers of longevity. The results of their study were published in the journal Cell Metabolism.
Researchers from Carnegie Mellon University and Nanyang Technological University, Singapore have developed an organ-on-an-electronic-chip platform, which uses bioelectrical sensors to measure the electrophysiology of the heart cells in three dimensions. These 3D, self-rolling biosensor arrays coil up over heart cell spheroid tissues to form an 'organ-on-e-chip,' thus enabling the researchers to study how cells communicate with each other in multicellular systems such as the heart.
To walk or run with finesse, roaches and robots coordinate leg movements via signals sent through centralized systems. Though their moving parts are utterly divergent, researchers have devised handy principles and equations to assess how both beasts and bots locomote and to improve robotic gait.
A new computational tool called ProtFus screens scientific literature to validate predictions about the activity of fusion proteins -- proteins encoded by the joining of two genes that previously encoded two separate proteins. Somnath Tagore in the Frenkel-Morgenstern Lab at Bar-Ilan University, Israel, and colleagues present ProtFus in PLOS Computational Biology.
In a survey, UC San Diego researchers report most patients are willing to share medical records for research purposes, with a few caveats.
Evidence shows that higher levels of physical activity -- regardless of intensity -- are associated with a lower risk of early death in middle aged and older people.
Freshwater wetlands from Georgia to New York are home to a previously unrecognized species of medicinal leech, according to scientists at the Smithsonian's National Museum of National History. The new species was first identified from specimens collected in southern Maryland less than 50 miles from Washington, D.C., prompting a search through marshes and museum collections that revealed that the leech has long occupied a range that stretches throughout the eastern United States.
A molecule called tRNA is an essential component of the human genome that acts as a translator. When researchers and clinicians investigate the genome's relation to disease, they have traditionally focused on mutations in the code for proteins. But now researchers at Western University have shown that the genes encoding tRNAs can also have mutations that cause the code to be misread, and in greater numbers than previously thought.
Although each and every one of us goes through it, aging is a poorly understood process. Researchers have used a biomarker called the epigenetic clock to identify a gene that is closely linked to aging in humans. This study shows that the epigenetic clock could be a good tool for improving our understanding of the molecular mechanisms behind aging.