In the era of personalized medicine, scientists are using new genetic and genomic insights to help them determine the best treatment for a given patient. Genomics researchers are increasingly turning to single-cell RNA sequencing to identify tumor subtypes. Lana Garmire, Ph.D. and her team have developed a bioinformatics method to cut through the noise of gene expression techniques by using single nucleotide variants.
With the help of machine learning, ETH researchers have been able to thoroughly describe the repertoire proteins on the cell surface for the first time. The latest findings are opening up new approaches in pharmaceutical research.
OIST researcher helps unravel the origins of vertebrate gene regulation in a large collaborative study.
Research at the Earlham Institute into one of the 'genetic orchestra conductors', microRNAs, sheds light on our selectively guided evolution of domestic pets and farmyard animals such as dogs and cows.
Only a fraction of the microbes residing in, on and around soils have been identified through efforts to understand their contributions to global nutrient cycles. Soils are also home to countless viruses that can infect microbes, impacting their ability to regulate these global cycles. In Nature Communications, giant virus genomes have been discovered for the first time in a forest soil ecosystem by researchers from the DOE Joint Genome Institute and the University of Massachusetts-Amherst.
Harvard researchers are among the co-editors of a special issue of Philosophical Transactions B dedicated to exploring the creative ways in which researchers have made use of biological collections around the world and to advocating for their continued preservation.
Using a highly-detailed musculoskeletal model of an echidna forelimb, Harvard scientists are not only shedding new light on how the little-studied echidna's forelimb works, but are also opening a window into understanding how extinct mammals might have used their forelimbs.
Truffles are the fruiting bodies of the ectomycorrhizal (ECM) fungal symbionts residing on host plant roots. In many Ascomycota and Basidiomycota lineages, truffle-forming species have evolved independently in nearly every major group. This suggests that symbiosis drives evolution of truffle diversity and selects for specific traits. As reported in Nature Ecology & Evolution, an international team sought insights into the ECM lifestyle of truffle-forming species, conducting a comparative analysis of eight Pezizomycete fungi.
Representing a group of successful biocontrol agents for various pest fruit flies, a parasitic wasp genus remains overlooked, with its most recent identification key dating back to 1969, even though many new species have been added since then. Through a recent study, published in the open access Biodiversity Data Journal, which also describes one new to science species, Swiss scientists demonstrate the advantages of new-age interactive identification keys, produced with specialised, free-to-use software.
DNA sequences with the potential to form unusual conformations, which are frequently associated with cancer and neurological diseases, can in fact slow down or speed up the DNA synthesis process and cause more or fewer sequencing errors.