Scientists at the John Innes Centre have come up with a novel way of quantifying cell shapes -- with a lot of mathematics and a little musical inspiration.
Research from a UC Santa Cruz Genomics Institute-affiliated team just published in the journal Nature Biotechnology attempts to close huge gaps remain in our genomic reference map. The research uses nanopore long-read sequencing to generate the first complete and accurate linear map of a human Y chromosome centromere. This milestone in human genetics and genomics signals that scientists are finally entering a technological phase when completing the human genome will be a reality.
Würzburg researchers have developed a new analysis technique that sheds more light on viral infections. They used the new method to demonstrate that virus-infected cells produce far more infection-related proteins and peptides than previously thought.
In Nature Biotechnology, an international team including scientists at the US Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility, present a reference catalog of rumen microbial genomes and isolates cultivated and sequenced from the Hungate1000 collection. One of the largest targeted cultivation and sequencing projects to date, the collection was produced through the coordinated efforts of rumen microbiology researchers worldwide.
One in four drugs with human targets inhibit the growth of bacteria in the human gut. These drugs cause antibiotic-like side-effects and may promote antibiotic resistance, EMBL researchers report in Nature on March 19.
Researchers at the University of Washington and the Allen Institute for Brain Science have developed a new method to classify and track the multitude of cells in a tissue sample. In a paper published March 15 in the journal Science, the team reports that this new approach -- known as SPLiT-seq -- reliably tracks gene activity in a tissue down to the level of single cells.
An article published in GigaScience presents a draft genome of a small shrew-like animal, the venomous Hispaniolan solenodon. This unusual animal is one of the only extant venomous mammals, and it is the sole remaining branch of mammals that split from other insectivores at the time of the dinosaurs. The solenodon genome sequence revealed the answer to several evolutionary questions, such as whether the solenodon species indeed survived the meteor impact that killed the dinosaurs.
In a paper published online March 5 in Nature Communications, University of Washington researchers unveiled an open-access browser to display, analyze and share neurological data collected through a type of magnetic resonance imaging study known as diffusion-weighted MRI.
One of the biggest current threats to global health is the rise of multi-drug resistant bacteria, caused by the spreading of antibiotic resistance amongst them. In an attempt to help fight this threat, EMBL researchers have unraveled the molecular basis of a major antibiotic resistance transfer mechanism. They also developed molecules and a proof-of-principle for blocking this transfer. Cell publishes their results on March 15.
Both cell type and developmental stage can be deduced from measurements of chromatin accessibility in thousands of single cells, researchers at EMBL and the University of Washington show. They used this approach to uncover how cells in developing embryos regulate their identity as they decide what kind of cell to become. Nature publishes the results on March 14.