For the first time, cellular machines called ribosomes -- which create proteins in every cell of the body -- have been linked to blood stem cell differentiation. The findings, published today in Cell, have revealed a potential new therapeutic pathway to treat Diamond-Blackfan anemia.
One family of genes allows cells to adapt to daily changes in environmental conditions by adjusting their internal 'body clock,' the circadian clock responsible for regular sleep-wake cycles. The new discovery by University of Tokyo scientists reveals for the first time that circadian regulation may be directly connected to cellular stress.
In the largest study of its kind, nine novel genes for osteoarthritis have been discovered by scientists from the Wellcome Sanger Institute and their collaborators. Results of the study, published today in Nature Genetics, could open the door to new targeted therapies for this debilitating disease in the future.
In the largest study of its kind, nine novel genes for osteoarthritis have been discovered by scientists from the University of Sheffield and their collaborators.
Every year, approximately 12 million adults in the US are diagnosed with Chronic Obstructive Pulmonary Disease, and 120,000 die from it. For people with COPD, Haemophilus influenzae, a bacterium, can be particularly dangerous. Now, researchers have unraveled how the bacterium adapts quickly, which may open new avenues for therapy for COPD and other diseases such as ear infections or pneumonia.
Two new biomarkers for a type of cancer in children called neuroblastoma have been identified in a study published in the journal Cancer Cell. The findings are expected to have immediate significance for disease prognosis, and eventually also for treatment.
Researchers at the University of Washington and the Allen Institute for Brain Science have developed a new method to classify and track the multitude of cells in a tissue sample. In a paper published March 15 in the journal Science, the team reports that this new approach -- known as SPLiT-seq -- reliably tracks gene activity in a tissue down to the level of single cells.
Tiny jumping fish can leap further as they get older, new research shows.
The journal Science published the research by biologists at Emory University, showing that a process known as hemimethylation plays a role in looping DNA in a specific way. The researchers also demonstrated that hemimethylation is maintained deliberately -- not through random mistakes as previously thought -- and is passed down through human cell generations.
Salk scientists create new molecular scissors to correct protein imbalance in cellular model of dementia.