Recently, researchers from Dr. Zhang Yongqing's group at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) found neurodevelopmental abnormality in a SHANK3-deficient non-human primate for the first time.
EPFL scientists show how DNA is organized into specific regions, and that this depends on a combination of genomic distance and the presence of the CTCF protein.
The earliest introduction of domestic chickens and black rats from Asia to the east coast of Africa came via maritime trade routes between the 7th and 8th centuries AD. In a paper published today in the journal PLOS ONE, an international team of researchers, led by director Nicole Boivin of the Max Planck Institute for the Science of Human History, used new techniques to analyze ancient DNA and proteins from nearly 500 bone samples.
A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns of individual cancers observed in the study strongly reinforces the need for personalized cancer treatment based on precision medicine.
A worm atlas has been built that profiles gene readouts for every kind of cell in the animal. This is the first time this type of comprehensive profiling for a multi-cellular organism has been created. The study was conducted at a larval stage of the roundworm C. elegans. The resource should have many uses, such as for studies on how genetic instructions guide the formation of body parts.
A female fruit fly must balance her energy usage between making eggs now and storing nutrients for later. This balance affects the pheromones that she produces and impacts whether male fruit flies find her attractive, report Tatyana Fedina of the University of Michigan and colleagues, Aug. 17, 2017 in PLOS Genetics.
Farmers can grow big, juicy tomatoes thanks to a mutation in the Cell Size Regulator gene that occurred during the tomato domestication process. Esther van der Knaap of the University of Georgia, Athens and colleagues describe this gene variant in a study published in open-access journal PLOS Genetics on Aug. 17, 2017.
Using fragments of circulating tumor DNA in blood, University of California San Diego School of Medicine researchers were able to identify theoretically targetable genetic alterations in 66 percent of patients with cancer of unknown primary (CUP), a rare disease with seven to 12 cases per 100,000 people each year.
After decades of relative neglect, star-shaped brain cells called astrocytes are finally getting their due. To gather insight into a critical aspect of brain development, a team of scientists examined the maturation of astrocytes in 3-D structures grown in culture dishes to resemble human brain tissue. The study, published in Neuron, confirms the lab-grown cells develop at the same rate as those found in human brains.
Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to five generations. They also identified the cause of these epigenetic changes, which is related to the loss of a molecular mechanism in charge of silencing genes.