Researchers from Michigan State University College of Human Medicine and physicians from Spectrum Health have identified for the first time in a human patient a genetic disorder only previously described in animal models.
Diabetes is not the only disease on which insulin has an effect, it appears. In a new study that involved tests on mice researchers from the University of Copenhagen, among others, have discovered a new method for treating chronic colitis with regular insulin. The researchers have set up a company with a view to testing the treatment and hopefully making it available to patients.
Genomic screening of more than 50,000 people shows that more than 80 percent of those who carry an identifiable genetic risk for breast, ovarian, prostate, and pancreatic cancer don't know it despite frequent interaction with the healthcare system.
A new study explores the mystery of what drives eating past the point of fullness, at the most basic level in the brain. It shows that two tiny clusters of cells battle for control of feeding behavior -- and the one that drives eating overpowers the one that says to stop. It also shows that the brain's own natural opioid system gets involved -- and that blocking it with the drug naloxone can stop over-eating.
IL1b, a member of the interleukin 1 family of cytokines (proteins released by certain cells of the immune system) drives the inflammation often found in cancer, and appears as an 'IL1 signature' in women with HER2-negative metastatic breast cancer. This signature can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target.
A rapid genetic test developed by Newcastle researchers has identified the first four patients with inherited mutations in a new disease gene, a building block of complex I called NDUFA6.
St. Jude Children's Research Hospital scientists have identified another way the process that causes oil to form droplets in water may contribute to solid tumors, such as prostate and breast cancer. Researchers found evidence that mutations in the tumor suppressor gene SPOP contribute to cancer by disrupting a process called liquid-liquid phase separation. Liquid-liquid phase separation is seen often in nature and is the reason why oil and vinegar separate in salad dressing.
When people take MDMA, the drug popularly known as ecstasy, a rush of serotonin, dopamine, and oxytocin produces feelings of emotional closeness and euphoria, making people more interested than normal in connecting with other people. Now, researchers reporting in Current Biology on Sept. 20 have made the surprising discovery that a species of octopus considered to be primarily solitary and asocial responds to MDMA similarly: by becoming much more interested in engaging with one other.
Recently, the U.S. National Institutes of Health (NIH) and Food and Drug Administration (FDA) called for the eliminating involvement of the Recombinant DNA Advisory Committee (RAC) in human gene therapy experiments, marking the end of an era of federal government oversight.
Scientists at the Centre for Genomic Regulation in Barcelona, Spain, have uncovered the role of special chemical 'tags' in controlling vital genes involved in early mammalian development, publishing their findings in the journal Nature Genetics.