Salk Institute researchers have developed a new tool -- dubbed SATI -- to edit the mouse genome, enabling the team to target a broad range of mutations and cell types. The new genome-editing technology could be expanded for use in a broad range of gene mutation conditions such as Huntington's disease and the rare premature aging syndrome, progeria.
An international group of scientists studied the effects of 17 different lifespan-extending interventions on gene activity in mice and discovered genetic biomarkers of longevity. The results of their study were published in the journal Cell Metabolism.
An international team of researchers who analyzed data across multiple ethnicities has produced the largest genetic study to date associated with common childhood obesity. The Early Growth Genetics Consortium discovered a robust new signal, fine-mapped previously reported genetic variants, and added to evidence that genetic influences on obesity operate across the lifespan.
Healthy mice study real-time gut colonization and discovered a pivotal role for bacterial sex in the evolution of the mammalian microbiome. This discovery constitutes a paradigm shift and opens the possibility to design new therapies.
MIT researchers have created a technology called DOMINO to store complex 'memories' in the DNA of living cells, including human cells. This memory storage capacity can form the foundation of complex circuits that trigger a cellular event, such as producing a fluorescent protein, when a specific event or sequence of events occurs.
Adults carrying a gene associated with a higher risk of Alzheimer's disease had a harder time accessing recently acquired knowledge, even though they didn't show any symptoms of memory problems, according to findings published in a joint Baycrest-University of Oxford study.
The first detailed map of individual malaria parasite behavior across each stage of its complicated life cycle has been created by scientists. Researchers used advanced single-cell technology to isolate individual parasites and measure their gene activity. The result is the Malaria Cell Atlas, which gives the highest resolution view of malaria parasite gene expression to date and monitors how individual parasites change as they develop in both the mosquito and human host.
In the first continent-wide genomic study of malaria parasites in Africa, scientists have uncovered the genetic features of Plasmodium falciparum parasites that inhabit different regions of the continent, including the genetic factors that confer resistance to anti-malarial drugs. This sheds new light on the way that drug resistance is emerging in different locations and moving by various routes across Africa, putting previous success in controlling malaria at risk.
MIT researchers have found that high levels of ketone bodies, molecules produced by the breakdown of fat, help the intestine to maintain a functional stem cell pool, which are crucial for intestinal regeneration.
Researchers have decoded a chain of molecules that are critical for the growth and survival of pancreatic ductal adenocarcinoma -- the most common and also the most lethal form of pancreatic cancer.