A new computational tool predicts genes that can cause disease due to the production of truncated or altered proteins that take on a new or different function, rather than those that lose their function.
A highly detailed study of how the roundworm C. elegans forms oocytes suggests that the egg-making process leads to the formation and subsequent destruction of cells with an extra nucleus, but that some cellular materials are recycled into new eggs. James Priess of the Fred Hutchinson Cancer Research Center and colleagues, report these findings in a new study published July 19th, 2018 in PLOS Genetics.
Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease. Experiments in cultured human cells reveal that blocking the protein reduces the characteristic sickling that distorts the shape of red blood cells and gives the disease its name.
CRISPR are an essential part of bacterial immunity designed to defend against foreign DNA. In bacteria, CRISPR acts just like it does in human cells as a pair of scissors, in their case with the goal of cutting strands of infecting DNA. While researchers have known that CRISPR is found in roughly half of all bacteria in the wild, they did not know much about the molecular battle between CRISPRs and invading viruses or phages.
For the first time, scientists have sequenced and analyzed the genomes of bacteria that live in anglerfish bulbs. The bacteria were taken from fish specimens collected in the Gulf of Mexico.
Research led by Suresh Alahari, PhD, Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has shown for the first time that a tiny piece of RNA deregulates energy metabolism, an emerging hallmark of cancer. The finding identifies a new target for therapeutic intervention in breast cancer.
Single-cell sequencing technologies are filling in fine details in the catalog of life. Researchers at the University of Connecticut Health Center (UConn Health) and The Jackson Laboratory (JAX) have identified 40 subtypes of retinal ganglion cells (RGCs) along with the genetic markers and transcription factors that differentiate them.
An international team of researchers has discovered that bacteria associated to Lagria villosa beetles can produce an antifungal substance very similar to one found in tunicates living in the marine environment. The researchers revealed that this commonality is likely explained by the transfer of genes between unrelated microorganisms.
Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice.
An international team of scientists led by Helmholtz Zentrum München and University of Copenhagen has presented the largest study so far on allergic rhinitis in the journal 'Nature Genetics'. The data of nearly 900,000 participants revealed loci in the human genome whose changes significantly increase the risk of disease.