Addressing concerns about gene drive releases in the wild, UC San Diego scientists and their colleagues have developed two new genetic systems that halt or eliminate gene drives after release. Created in fruit flies, the e-CHACRs and ERACRs are powerful gene drive control mechanisms that were meticulously developed and tested at the genetic and molecular levels.
By comparing genetic variants differing in the two fly populations, researchers found that polygenic traits led to the quickness of adaptation; many genes, each with very small effects, worked together to determine the rate of development. The research illustrates that crop pests and insect disease vectors with similar biology may rapidly respond to changing climates by a similar genetic mechanism.
A team of international collaborators identifies a new cause of syndromic microcephaly caused by LMNB1 mutations that disrupt the nuclear envelope. The report is published in the October issue of the American Journal of Human Genetics.
For the first time, scientists have studied the early effects of time-restricted feeding on the daily periodic oscillations of metabolites and genes in muscle, and metabolites in blood. The findings by scientists at the University of Copenhagen, the Australian Catholic University and Karolinska Institutet find that time-restricted feeding does not influence the muscle's core clock, and opens the door to more research on how these observed changes improve health.
Princeton researchers Rachel Kaletsky, Rebecca Moore, Coleen Murphy and colleagues have discovered that the microscopic roundworm Caenorhabditis elegans recognizes a small RNA made by a pathogenic bacterium, and uses that RNA to convey learned avoidance of the bacterium to offspring. Their work appears in the Sept. 9, 2020 issue of Nature.
Healthy NEMF helps the cell recycle garbled protein fragments. But several mutant forms resulted in neuromuscular, neurodegenerative or other ALS-like disease, the scientists found.
DNA replication begins with a set of proteins--the Origin of Replication Complex (ORC). Cold Spring Harbor Laboratory (CSHL) researchers published images of the human ORC in exquisite detail, showing how it changes shapes in dramatic ways as it assembles around DNA.
Our notion of the Scandinavian Viking very likely stems from films rather than history. In reality, their genome contains lots of genes from Southern and Eastern Europe, which also implies that they had dark rather than blonde hair. And within the Scandinavian borders, the Vikings did not really mix genetically; instead, they travelled abroad on plundering raids. This is revealed by new research from the University of Copenhagen.
Invaders, pirates, warriors - the history books taught us that Vikings were brutal predators who travelled by sea from Scandinavia to pillage and raid their way across Europe and beyond. Now cutting-edge DNA sequencing of more than 400 Viking skeletons from archaeological sites scattered across Europe and Greenland will rewrite the history books.
From Alzheimer's to obesity, life can change dramatically if you discover you have a genetic risk of disease. Now, a new study from the Australian Centre for Precision Health, University of South Australia is challenging these predispositions, showing that some of the genes traditionally labelled as 'bad' are not always what they seem.