A naturally occurring antibiotic called kanglemycin A is effective against Mycobacterium tuberculosis, the bacteria that cause tuberculosis, even in drug-resistant strains, according to an international team of researchers who used chemistry, molecular biology, microbiology, and X-ray crystallography to show how the compound maintains its activity.
A novel study indicates promising avenues in an innovative approach for developing a vaccine against Plasmodium vivax, the most prevalent human malaria parasite outside sub-Saharan Africa. The study, led by researchers from the Barcelona Institute for Global Health, indicates the possibility of using small vesicles (or exosomes) secreted by immature red blood cells as a vaccine platform against malaria. The paper, carried out in collaboration with IrsiCaixa AIDS Research Institute, was published in Scientific Reports.
A rapid genetic test developed by Newcastle researchers has identified the first four patients with inherited mutations in a new disease gene, a building block of complex I called NDUFA6.
Peer-reviewed / Modelling and review. Cancers, cardiovascular diseases, chronic respiratory diseases, and diabetes were responsible for 12.5 million deaths among people aged 30-70 years worldwide in 2016. Warning as more than half of all countries are not on track to achieve a UN target to reduce by a third the rate of premature deaths from non-communicable diseases (NCDs) by 2030.
Scientists have found a way to boost the efficacy of the antimalarial drug artemesinin with the help of chemotherapy medicines. Artemisinin works through a 'double whammy' attack on the deadly parasite. The drug damages proteins in malaria parasites and clogs the parasite's waste disposal system, known as the proteasome, which chemo can target.
New high-resolution maps pinpoint areas across Africa with concentrations of child deaths from diarrhea and show uneven progress over 15 years to mitigate the problem. The study, covering 2000 to 2015, maps the entire African continent in 5x5 square kilometer units and was published today in The New England Journal of Medicine. National and provincial maps of diarrhea in Africa often mask inequalities at the local community level, according to IHME researchers.
Researchers at The University of Texas Medical Branch at Galveston have successfully harnessed their Zika virus vaccine to target and kill brain cancer known as glioblastoma.
Boys who have considerable weight gain between childhood and puberty, double the risk of having asthma as an adult, and for future offspring.
Our result suggests preoperative albumin level as an independent risk factor for PPCs in elderly gastric cancer (GC) patients after elective laparoscopic gastrectomy. We also suggest that those elderly hypoalbuminemic GC patients may benefit from more intensive perioperative care including perioperative nutritional status improvement.
Researchers have identified compounds that could prevent malaria parasites from being able to infect mosquitoes, halting the spread of disease.