A new study offers a rare glimpse into the genetics of a herpes simplex virus transmission event -- information that may prove useful in future development of therapeutics and vaccines. The study reveals nearly perfect genetic transmission of the virus from a father to his son and lays the foundation for future studies exploring the genetic diversity of this virus.
In the cover article in the current issue of Cell, BU Biomedical Engineer Ahmad S. Khalil along with colleagues from MIT and the Whitehead Institute for Biomedical Research, among others, describe the synthetic genetic tool they built to quantitatively sense, measure and manipulate protein aggregation in live cells. This may open the door to greater understanding and treatment of a range of maladies from Alzheimer's to type II diabetes.
Little is known about the structures of our genetic material, chromosomes, which consist of long strings that -- according to our experience -- should be likely to become knotted. However, up to now it has not been possible to study this experimentally. Researchers at Johannes Gutenberg University Mainz (JGU) in Germany have now found that chromosomes may indeed be knotted.
Researchers at Umeå and Stockholm universities in Sweden and Johns Hopkins University School of Medicine in the US have published a new study in the journal Molecular Cell. In the article, they show how the protein CBP affects the expression of genes through its interaction with the basal machinery that reads the instructions in our DNA.
Multi-omics profiling, the measurement and analysis of a person's genome along with other biomolecular traits, is an important step toward personal health management that provides valuable, actionable information, according to findings presented at the American Society of Human Genetics 2017 Annual Meeting in Orlando, Fla.
Low levels of physical activity and inefficient sleep patterns intensify the effects of genetic risk factors for obesity, according to results of a large-scale study presented at the American Society of Human Genetics (ASHG) 2017 Annual Meeting in Orlando, Fla. These results confirm and strengthen previous findings based on self-reported activity.
Rare variants combined with background genetic risk factors may account for many unexplained cases of familial breast cancer, and knowing the specific genes involved could inform choice of prevention and treatment strategies, according to findings presented in a plenary session at the American Society of Human Genetics (ASHG) 2017 Annual Meeting in Orlando, Fla.
Research has shown that a mother's diet during pregnancy, particularly one that is high-fat, may program her baby for future risk of certain diseases such as diabetes. A new study from nutrition researchers at the University of Illinois shows that switching the offspring to a new diet -- a low-fat diet, in this case -- can reverse that programming.
A study published in the journal Molecular Therapy by Christian Mueller, PhD, shows that using nuclease-free gene editing to correct cells with the mutation that causes alpha-1 antitrypsin deficiency leads to repopulation of a diseased liver with healthy cells. It has the potential to prevent liver and lung damage from forming in very young alpha-1 patients.
A yeast protein that evolved from scratch can fold into a compact three-dimensional shape -- contrary to the general understanding of young proteins. Recent evidence suggests new genes can arise from the non-coding sections, or 'junk,' DNA and that those new genes could code for brand-new proteins. Scientists thought such newly evolved proteins were works-in-progress that could not fold into complex shapes the way more ancient proteins do.