UTA researchers set out to determine whether pythons could have adapted to an extreme Florida freeze event in 2010. They generated data for dozens of samples before and after the freeze event. By scanning regions of the Burmese python genome, they identified parts of the genome that changed significantly between the two time periods, providing clear evidence of evolution occurring over a very short time scale in this population.
Mount Sinai Scientists developed a novel way to barcode and track different CRISPRs by utilizing synthetic proteins built from combinations of smaller proteins, called epitopes. By being able to mark each CRISPR with a unique identifier, the protein barcodes, or Pro-Codes for short, enable hundreds of CRISPRs to be used together to knockout a multitude of genes.
In new studies conducted at UC San Francisco, a novel oxygen-delivery therapeutic restored the function of oxygen-starved heart tissue in an animal model of global hypoxia. Unlike its experimental predecessors, the new drug does not appear to cause systemic side effects or overcorrect with excessive blood oxygenation, which can itself be toxic. Instead, the new drug delivers its precious oxygen cargo only to the tissues that need it most.
A new Florida State University College of Medicine study in mice produced results that suggest nicotine exposure in men could lead to cognitive deficits in their children and grandchildren. Further studies will be required to know if the same outcomes seen in mice would apply to humans.
Researchers have taken advantage of the benefits of DNA immunization over traditional protein-based immunization to elicit monoclonal antibodies (mAbs) against challenging targets in three species -- mouse, rabbit, and human models.
This study shows that Src is necessary and sufficient to activate mTORC1 and offers the possibility to develop novel approaches to control cancer growth.
Scientists studying a valuable, but vulnerable, species of poplar have identified the genetic mechanism responsible for the species' inability to resist a pervasive and deadly disease. Their finding, published in the Proceedings of the National Academy of Sciences, could lead to more successful hybrid poplar varieties for increased biofuels and forestry production and protect native trees against infection.
A University of Colorado Denver-led research team for the first time developed reliable genetic markers known as nuclear microsatellites for the whitebark pine, a discovery that could improve the tree's prospects for survival. Whitebark pine, which is declining rapidly nearly range-wide, is currently being considered for listing under the Endangered Species Act.
Scientists at Oregon State University have shed light on the evolutionary history of a soil-borne bacteria that is so dangerous to grazing animals it is kept behind lock-and-key to prevent its spread.
A new study published this week found that the social lives of sweat bees -- named for their attraction to perspiration -- are linked to patterns of activity in specific genes, including ones linked to autism.