The two-gene medication has been proven to recover motor functions in rats. After several months of treatment, rodents were able to use previously paralyzed limbs. Researchers at Kazan Federal University are now seeking pre-clinical trial investment.
In a new study from the Intermountain Healthcare Heart Institute in Salt Lake City, researchers have identified eight new gene mutations that may cause or contribute to idiopathic dilated cardiomyopathy, a form of heart disease not caused by known external influences, such as high blood pressure, obesity, smoking, or diseased coronary arteries.
Australian researchers have used hepatitis B virus genome sequences to deduce that the mainland Aboriginal population separated from other early humans at least 59,000 years ago.
A research group led by Professor GUO Yalong from the Institute of Botany of the Chinese Academy of Sciences, together with SONG Ge, and Sureshkumar Balasubramanian from the School of Biological Sciences, Monash University, Australia, has revealed that transposable element insertions could potentially help species with limited genetic variation adapt to novel environments.
In a perspectives article published in the prestigious journal Science, Dr. Jaclyn Biegel, from Children's Hospital Los Angeles and Dr. Alejandro Sweet-Cordero, of the University of California, San Francisco, survey the landscape on the use of precision medicine in pediatric oncology and present opportunities for using genomic information to advance a new era of care for children with cancer.
An international study co-led by researchers from the Spanish National Research Council (CSIC) at the Institute of Evolutionary Biology (IBE) and Harvard University (USA) has developed a genetic map of the Iberian Peninsula covering the last 8,000 years.
Researchers from the University of Copenhagen have discovered autoreactive cells in persons suffering from narcolepsy. This is a new, important proof that the sleep disorder is an autoimmune disease. This knowledge may lead to better treatment of the chronic condition, the researchers behind the new discovery believe.
People left blind by retinal degeneration have one option: electronic eye implants. UC Berkeley neuroscientists have developed an alternative: gene therapy that, in tests, restored vision in blind mice. A gene for green opsin delivered via virus gave blind mice enough sight to discern patterns on an iPad at a resolution sufficient for humans to read. Given existing AAV eye therapies already approved, this new therapy could be ready for clinical trials in three years.
A human's health is shaped both by environmental factors and the body's interactions with the microbiome, particularly in the gut. Genome sequences are critical for characterizing individual microbes and understanding their functional roles. However, previous studies have estimated that only 50 percent of species in the gut microbiome have a sequenced genome, in part because many species have not yet been cultivated for study.
The University of Huddersfield's Archaeogenetics Research Group joins an international team to conduct the largest-ever study of ancient DNA from the Iberian Peninsula (Spain and Portugal) which suggests that the Iberian male lineages were almost completely replaced between 4,500 and 4,000 years ago by newcomers originating on the Russian steppe.