A new University of Washington-led study examines one key stress-inducing circumstance -- the effects of social hierarchy -- and how cells respond to the hormones that are released in response to that stress.
Red wolves, once nearly extinct, again teeter on the abyss. New research finds red wolf ancestry in Texas -- providing opportunities for additional conservation action and difficult policy challenges. Michigan Tech researcher Kristin Brzeski and others have identified red wolf "ghost alleles" in canid population on Galveston Island.
An analysis of nearly 20,000 cancer patient histories and genetic data has revealed that knowing the genetic cause of a cancer does not help predict how deadly the disease will be. Instead, researchers from CSHL have discovered that copy number variations in specific gene sites are far more informative, providing new opportunities to improve prognosis.
According to some estimates, up to one in three people around the world may experience severe anxiety in their lifetime. In a study described today in Cell Reports, researchers at the Weizmann Institute of Science have revealed a previously unknown mechanism underlying anxiety. Targeting this biochemical pathway may help develop new therapies for alleviating the symptoms of anxiety disorders.
Researchers have genetically transformed the Common Primrose (Primula vulgaris) for the first time in a development that could shed light on one of the plant world's most renowned reproductive systems.
A paternal grandfather's access to food during his childhood is associated with mortality risk, especially cancer mortality, in his grandson, shows a large three-generational study from Stockholm University. The reason might be epigenetic -- that environmental exposures in one generation may influence health outcomes in following generations.
For the first time ever, biomedical researchers from Aarhus University, Denmark, have unveiled cellular defects that lead to the rare disease hereditary angioedema (HAE), where patients experience recurrent episodes of swelling that requires immediate treatment. This new understanding is an important step towards gene therapy for patients.
An international team of cancer researchers from Denmark and Germany have used cancer patient data to develop a computer model that can predict the course of disease for prostate cancer. The model is currently being implemented at a prostate cancer clinic in Germany. The researchers have also found the enzyme that appears to trigger some of the first mutations in prostate cancer.
Starting with human brain tissue from patients with epilepsy, University of Iowa researchers used gene expression profiling and bioinformatics to identify 91 FDA-approved drugs, that may also have potential as anti-epilepsy treatments. Testing showed three of drugs -- a diabetes drug, a hypertension medication, and an antiparasitic therapy -- significantly reduced seizure-like movement in zebrafish.
A nationwide research team has found a strong relationship between early-onset Afib and mutations that break TTN, a gene that helps maintain the structure of heart muscle. According to these new findings, roughly two percent of the nearly 2,800 early-onset Afib patients examined had a loss-of-function mutation in TTN, a percentage that increased the younger a patient was. TTN is also associated with many forms of cardiomyopathy.