A team of MIT biological engineers has developed a method to measure levels of heme, a critical iron-containing molecule, inside the parasite that causes malaria. This could eventually help scientists develop better drugs to combat the disease.
A new report by the World Health Organization lays out, for the first time, which antibiotic-resistant bacteria pose the greatest risk to global health and urgently need new effective treatments. The report was chaired by Prof. Evelina Tacconelli, executive committee member of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) in collaboration with the WHO and with input from several ESCMID experts.
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new regulator of the innate immune response -- the immediate, natural immune response to foreign invaders. The study, published recently in Nature Microbiology, suggests that therapeutics that modulate the regulator -- an immune checkpoint--may represent the next generation of antiviral drugs, vaccine adjuvants, cancer immunotherapies, and treatments for autoimmune disease.
A study by scientists at Indiana University has found that the master gene that regulates differences between males and females plays a complex role in matching the right physical trait to the right sex. The research, published Feb. 27 in the journal Nature Communications, reveals new details about the behavior of the gene called 'doublesex,' or dsx.
Genes from a common bacterium can be harnessed to sterilize male insects, a tool that can potentially control populations of both disease-bearing mosquitoes and agricultural pests, researchers at Yale University and Vanderbilt University report in related studies published Feb. 27 in two Nature journals.
Discovery of the genes the insect parasite Wolbachia uses to control its hosts' reproduction provides a powerful new tool for enhancing biological control efforts for mosquito-borne diseases like dengue, Zika and malaria.
Sometimes cells spit out things we don't want them to -- like medications. Researchers have determined the three-dimensional structure of a tiny pump that expels, among other things, chemotherapy agents. This new knowledge could lead to the design of more effective drugs.
New research pinpoints just how bacteria get into human lungs, and opens the door to more research on what happens to them -- and our bodies -- as a result of the lung microbiome.
Many recent reports have found multidrug resistant bacteria living in hospital sink drainpipes, putting them in close proximity to vulnerable patients. But how the bacteria find their way out of the drains, and into patients has been unclear. Now a team from the University of Virginia, Charlottesville, has charted their pathways. The research is published Feb. 24 in Applied and Environmental Microbiology, a journal of the American Society for Microbiology.
Current treatments for rheumatoid arthritis relieve the inflammation that leads to joint destruction, but the immunologic defect that triggers the inflammation persists to cause relapses. Known as autoantibodies and produced by the immune system's B cells, these defective molecules mistakenly attack the body's own proteins in an example of autoimmune disease.