Researchers from the University of Oxford's Department of Zoology have demonstrated pre-clinical success for a universal flu vaccine in a new paper published in Nature Communications.
Imagine your liver being just a big puddle. Some organelles in your cells are exactly that including prominent ones like the nucleolus. Now a synthetic organelle engineered in a lab at Georgia Tech shows how such puddle organs can carry out complex life-sustaining reaction chains.
A naturally occurring antibiotic called kanglemycin A is effective against Mycobacterium tuberculosis, the bacteria that cause tuberculosis, even in drug-resistant strains, according to an international team of researchers who used chemistry, molecular biology, microbiology, and X-ray crystallography to show how the compound maintains its activity.
Researchers from Newcastle University and Demuris Ltd have identified that a naturally occurring antibiotic, called kanglemycin A -- related to the antibiotic rifampicin -- is active against rifampicin-resistant Mycobacterium tuberculosis.
St. Jude Children's Research Hospital scientists have identified another way the process that causes oil to form droplets in water may contribute to solid tumors, such as prostate and breast cancer. Researchers found evidence that mutations in the tumor suppressor gene SPOP contribute to cancer by disrupting a process called liquid-liquid phase separation. Liquid-liquid phase separation is seen often in nature and is the reason why oil and vinegar separate in salad dressing.
A non-pathogenic fungus can expand in the intestines of antibiotic-treated mice and enhance the severity of allergic airways disease, according to a study published Sept. 20 in the open-access journal PLOS Pathogens by David Underhill of Cedars-Sinai Medical Center, and colleagues. The findings suggest that alterations in gut microbiota induced by intestinal fungi might be a previously unrecognized but potentially important risk of antibiotic therapy in patients with asthma and other respiratory diseases.
In 2014, a dengue outbreak unexpectedly occurred in Tokyo. What does that mean for the 2020 summer Olympics and Paralympics being held in the city? Researchers report this week in PLOS Neglected Tropical Diseases that new controls and frameworks are recommended to detect dengue and other infectious diseases and help prevent their spread during the summer games.
Stiff microbial films often coat medical devices, household items and infrastructure such as the inside of water supply pipes, and can lead to dangerous infections. Researchers have developed a system that harnesses the power of bubbles to propel tiny particles through the surfaces of these tough films and deliver an antiseptic deathblow to the microbes living inside.
Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet. The researchers also reported that the NLRP12 gene is underactive in people who are obese, making it a potential therapeutic target for treating obesity and diabetes, both of which are risk factors for cardiovascular disease and other serious conditions.
A new cell culture platform allows researchers to observe never-before-seen behaviors of live cancer cells under the microscope, leading to explanations of long-known cancer characteristics.