A new, computer-based screening method could reveal the virus-fighting potential of drugs originally developed to treat other conditions, reports a study in PLOS Computational Biology.
Glioblastomas exert an influence on the microglia, immune cells of the brain, which causes them to stimulate cancer growth rather than attacking it. In a study published in the journal Nature Immunology, an international research team led from Sweden's Karolinska Institutet now explains the molecular mechanisms behind this action.
University of Utah researchers have found that the structure of an insulin molecule produced by predatory cone snails may be an improvement over current fast-acting therapeutic insulin.
A new study in the Proceedings of the National Academy of Sciences provides substantial new evidence that health becomes endangered when aging cells lose control of rogue elements of DNA called transposons.
A series of new studies led by scientists at The Scripps Research Institute and the International AIDS Vaccine Initiative describe a potential vaccination strategy to jump-start the selection and evolution of broadly effective antibodies to prevent HIV infection. The researchers plan to test this strategy in an upcoming human clinical trial.
Researchers at the University of Adelaide have shown how a complex mix of plant compounds derived from ancient clinical practice in China -- a Traditional Chinese Medicine -- works to kill cancer cells.
An animal study suggests that resistance to tamoxifen therapy in some estrogen receptor positive breast cancers may originate from in utero exposure to endocrine disrupting chemicals. The study provides a new path forward in human research as about half of the breast cancers treated with this common cancer therapy do not respond well, say researchers at the Georgetown Lombardi Comprehensive Cancer Center, who led the multi-institutional research.
In this issue of JCI Insight, researchers led by Iris Jaffe of Tufts Medical Center provide evidence that age-related reductions of a microRNA (miR-155) underlie age-associated hypertension.
In this issue of JCI Insight, Jonathan Perkins of University of Washington and colleagues analyzed infantile hemangioma tumor tissue, infantile hemangioma patient plasma, and non-infantile hemangioma vascular anomalies to identify a set of microRNAs that are specific for infantile hemangioma.
In this issue of JCI Insight, Pierre Henri Mangin and colleagues at the Etablissement Français du Sang-Alsace have shown that a molecule expressed on platelets, known as α6β1 integrin, participates in tumor metastasis by promoting interactions between tumor cells and platelets.