The mystery of what controls the range of developmental clocks in mammals -- from 22 months for an elephant to 12 days for a opossum -- may lie in the strict time-keeping of pluripotent stem cells for each unique species.
Researchers have designed a 3-D-printed porous scaffold for use in reconstructing ruptured anterior cruciate ligaments (ACL) in the knee and engineered it to deliver a human bone-promoting protein over an extended period of time to improve bone regeneration.
Scientists at Rutgers and other universities have created a new way to identify the state and fate of stem cells earlier than previously possible. Understanding a stem cell's fate -- the type of cell it will eventually become -- and how far along it is in the process of development can help scientists better manipulate cells for stem cell therapy.
Scientists at The Wistar Institute and Inovio Pharmaceuticals, Inc. have devised a novel DNA vaccine approach through molecular design to improve the immune responses elicited against one of the most important cancer antigen targets.
Researchers at the Centre for Genomic Regulation developed Global Score, a method that allows, for the first time, to predict protein interactions with long non-coding RNAs. This algorithm helps scientists prioritize binding partners for experimental validation, which will contribute to our understanding of the role of long non-coding RNAs in normal cell function and in disease.
A Caltech-led study has shown that the electrical wire-like behavior of DNA is involved in the molecule's replication.
Current treatments for rheumatoid arthritis relieve the inflammation that leads to joint destruction, but the immunologic defect that triggers the inflammation persists to cause relapses. Known as autoantibodies and produced by the immune system's B cells, these defective molecules mistakenly attack the body's own proteins in an example of autoimmune disease.
How can the same infection result in dramatically different levels of illness in two different people? A new study identifies two conditions -- a genetic immunodeficiency and delayed acquired immunity -- that explain why a patient developed a life-threatening disease in response to a common strain of bacterium.
Researchers at the Whitehead Institute have now uncovered a role for the protein-folding chaperone HSP90 in humans, not only as a modifier of the effects of mutations, but as a mediator of the impact of the environment on the function of mutant proteins. And these effects of HSP90 can alter the course of human diseases.
For the first time a molecular 'tipping point' has been demonstrated in Alzheimer's, linking high blood sugar with this debilitating disease