Researchers at NSLS-II used ultrabright x-rays to generate 3D nanoscale maps of a single bacteria's chemical composition with unparalleled spatial resolution.
Freiburg scientists elucidate the mechanism for the transport of water-insoluble protein molecules in mitochondria
In optogenetics, researchers use light to control protein activity. This technique allows them to alter the shape of embryonic tissue and to inhibit the development of abnormalities. Now, scientists in EMBL's De Renzis group have enhanced the technique to stop organ-shaping processes in fruit fly embryos. Their results, published in The EMBO Journal, allow control over a crucial step in embryonic development.
Researchers at the National Institute for Physiological Sciences found that the filamin A-Drp1 complex mediates mitochondrial fission in a mouse model of hypoxic heart cells. Results show that hypoxic stress brought about the interaction of filamin A with Drp1 and increased Drp1 activity in heart cells. This process led to mitochondrial fragmentation and cell senescence. Further investigation demonstrated that the drug cilnidipine suppressed Drp1-filamin A complex formation and preserved heart cell function.
As part of the cellular conservation of endangered species, our group initiated a primary cell culture project aimed at preserving endangered avian species in Japan, such as the Okinawa rail. However, primary cells cannot be cultured indefinitely because of cellular senescence and stresses caused by cell culture. To overcome these cell culture limitations, primary cells must be immortalized. As a result, we succeeded to obtain the immortalized avian cells with cell cycle regulation genes expression.
A new Tel Aviv University study finds that the drug candidate CP201, also known as NAP, may improve vocal communication abilities in patients with ADNP syndrome, a rare genetic condition.
Scientists at Scripps Research have discovered that a mysterious family of cellular proteins called OSCAs and TMEM63s are a novel class of mechanosensitive ion channels. The scientists also deciphered the atomic structure of one member of the OSCA protein family, an advance that will allow them to study how these ion channels do their jobs, information that could be critical to identifying how dysfunctions in mechanosensing play a role in disease.
Patients with rare, but incurable cancers of the digestive tract have responded well to a combination of two drugs that block the MEK and BRAF pathways, which drive the disease in some cases. They have survived for longer without the disease progressing than the usual average time of less than five months, even though their cancer was advanced and had not responded to previous therapies. The research is presented at the 30th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland.
An analysis of Twitter data from the US shows that social media usage largely mirrors daily work schedules and school calendars. The data reflect the amount of 'social jet lag' caused when social demands make people wake up much earlier than their biological rhythms would prefer.
The sight or smell of something delicious is often enough to get your mouth watering, but the physiological response to food perception may go well beyond your salivary glands. New research in mice shows that the sight and smell of food alone may be enough to kickstart processes in the liver that promote the digestion of food. The study appears Nov. 15 in the journal Cell.