New study calls for human-based tools to unravel the pathogenesis of non-alcoholic steatohepatitis (NASH). The contribution of in silico, in vitro and pathways-based systems biology approaches to unraveling the pathogenesis of this disease are described, and how this human-relevant research can be used for anti-NASH drug development.
A new study by researchers at Okinawa Institute of Science and Technology Graduate University (OIST), provides evidence towards selection in mtDNA due to variations in temperature.
In a new study, a team led by University of Utah biologists has discovered that different versions of a single gene, called NDP (Norrie Disease Protein), have unexpected links between color patterns in pigeons, and vision defects in humans. These gene variations were likely bred into pigeons by humans from a different pigeon species and are now evolutionarily advantageous in wild populations of feral pigeons living in urban environments.
Studying the photochemistry has shown that ultraviolet radiation can set off harmful chemical reactions in the human body and, alternatively, can provide 'photo-protection' by dispersing extra energy. To better understand the dynamics of these photochemical processes, a group of scientists irradiated the RNA base uracil with ultraviolet light and documented its behavior on a picosecond timescale. They discuss their work this week in The Journal of Chemical Physics.
How do scale patterns on fish provide understanding of the development of feathers, fur -- and even cancer? Biologists are investigating.
A new molecule designed by University of Adelaide researchers shows great promise for future treatment of many cancers.
One major problem with understanding Alzheimer's is not being able to clearly see why the disease starts. A super-resolution 'nanoscope' developed by Purdue University researchers now provides a 3D view of brain molecules with 10 times greater detail. This imaging technique could help reveal how the disease progresses and where new treatments could intervene.
Scientists have long known that RNA encodes instructions to make proteins. The building blocks that comprise RNA--A, U, C, and Gs--form a blueprint for the protein-making machinery in cells. In a new study published in Nature, scientists describe how the protein-making machinery identifies alternative initiation sites from which to start protein synthesis.
A University of Queensland-led international study could lead to more accurate predictions or the rate of global warming from greenhouse gas emissions produced by thawing permafrost in the next 100 years. The study of the microorganisms involved in permafrost carbon degradation links changing microbial communities and biogeochemistry to the rise of greenhouse gas emissions.
A new study in The American Journal of Pathology found that a brain lipid molecule, lysophosphatidic acid (LPA), was significantly increased after traumatic brain injury (TBI) in a preclinical animal model. They also found that it was elevated in areas associated with cell death and axonal injury, both major hallmarks of moderate and severe TBI. This strengthens the evidence that LPA could be used as a biomarker of TBI through blood testing, potentially providing a prognostic indicator of injury and outcome.