Scientists at the Charité - Universitätsmedizin Berlin found which molecules of the house dust mites are initially targeted by the immune system of children developing, even years later, allergic rhinitis and asthma. The discovery, published in the Journal of Allergy and Clinical Immunology, will open up new avenues not only to novel and more precise therapies, but also to a successful prediction and prevention of chronic rhinitis and asthma caused or aggravated by allergy to house dust mites.
Researchers have found Mendel's Stay-Green gene encodes an enzyme that extracts magnesium from chlorophyll, adding clarity to understanding how the pigment degrades.
Modern mass spectrometry systems enable scientists to routinely determine the quantitative composition of cells or tissue samples. However, different analysis software packages often produce different results from the same raw data. An international team of researchers led by Professor Stefan Tenzer from the Mainz University Medical Center has now addressed this problem by comparing and modifying various analysis software packages to ensure that the different software solutions produce consistent results.
Medical researchers at Indiana University have found evidence for a link between prostate cancer, which affects millions of men age 50 and older, and Ewing's sarcoma, a rare form of cancer that affects children and young adults. The results appear in the journal Cell Reports.
A protein known for guarding against viral infections leads a double life, new research shows, and can interfere with cell growth and the defense against parasites. In a new paper publishing Oct. 25 in the open-access journal PLOS Biology, Johnathan Ho and Uwe Vinkemeier at the University of Nottingham, UK, and colleagues describe the duplicitous nature of this essential protein, called STAT2, which they discovered while investigating the mechanisms behind interferon signaling.
It's widely accepted that vitamin D is good for bones. But what if it plays a much larger role in health than is currently accepted? Recent research at the Buck Institute points in that direction -- at least in the nematode worm. The study shows vitamin D works through longevity genes and impacts processes associated with many human age-related diseases. The research is prompting some clinicians to call for universal vitamin D supplementation.
Researchers from Yale-NUS College have partnered with researchers from the National University of Singapore and SingHealth Group to develop a novel Caenorhabditis elegans worm strain which expresses an amyloid beta protein fragment involved in the development of human Alzheimer's disease (AD). This strain will serve as a tool for the testing of interventions against AD and to help researchers understand the disease better.
Viruses hijack the molecular machinery in human cells to survive and replicate, often damaging those host cells in the process. Researchers at the University of California San Diego School of Medicine discovered that, for cytomegalovirus (CMV), this process relies on a human protein called CPEB1. The study provides a potential new target for the development of CMV therapies.
Scientists have long known that chronic exposure to psychosocial stress early in life can lead to an increased vulnerability later in life to diseases linked to immune dysfunction and chronic inflammation, including cancer, diabetes and heart disease. But the molecular mechanisms underlying these negative effects are unknown. Using the zebrafish as a model, developmental biologist James A. Coffman, Ph.D., of the MDI Biological Laboratory in Bar Harbor, Maine, is beginning to elucidate these mechanisms.
How do you improve a Nobel Prize-winning discovery? Add a debilitating disease-causing gene mutation. In a study published in the journal Proceedings of the National Academy of Sciences, Shinya Yamanaka, M.D., Ph.D., who first created induced pluripotent stem cells (iPSCs), and his colleagues at the Gladstone Institutes found a way to increase the efficiency of stem cell reprogramming through research on a rare genetic disease.