Researchers at Washington State University have recently identified a DNA region known as VNTR2-1 that appears to drive the activity of the telomerase gene, which has been shown to prevent aging in certain types of cells. Knowing how the telomerase gene is regulated and activated and why it is only active in certain cell types could someday be the key to understanding how humans age and how to stop the spread of cancer.
Every drug starts with the search for an active substance targeting disease-related key players. However, there is no perfect drug that affects the one target: no effect without side effects. A group led by Prof. Herbert Waldmann and Dr. Slava Ziegler at the Max Planck Institute of Molecular Physiology in Dortmund has now identified an unexpected effect for a group of characterized active substances: they all modulate cholesterol metabolism, a home-made problem, as it seems.
Over the last few decades, neurodegenerative diseases became one of the top 10 global causes of death. Researchers worldwide are making a strong effort to understand neurodegenerative diseases pathogenesis, which is essential to develop efficient treatments against these incurable diseases. A team of researchers found out the implication of lysosomes in the spread of Parkinson's disease.
Replication of SARS-CoV-2, the virus responsible for COVID-19, depends on a series of interactions between viral proteins and different cellular partners such as nucleic acids (DNA or RNA). Characterizing these interactions is crucial to elucidate the process of viral replication and identify new drugs for treating COVID-19.
DeepMind is partnering with EMBL to make the most complete and accurate database yet of the predicted human protein structures freely and openly available to the scientific community The AlphaFold Protein Structure Database will enable research that advances understanding of these building blocks of life, accelerating research across a variety of fields. AlphaFold's impact is already being realised by early partners researching neglected diseases, studying antibiotic resistance, and recycling single-use plastics.
Researchers from Osaka University have found that the attachment of a ubiquitin molecule to a protein called PCNA at the lysine 107 position causes gross chromosomal rearrangements. This lysine is located where two PCNA molecules interact, and the ubiquitin attachment to it may change the ring structure they form. The ubiquitin attachment occurs through the action of Rad8 (a ubiquitin ligase) and Mms2-Ubc4 (a ubiquitin conjugating enzyme). This implies that inhibiting the human equivalent of this ubiquitination could prevent cancer.
In a new study, researchers have uncovered how cytolysins from Enterococcus faecalis destroys bacterial and mammalian cells.
Study with cell cultures shows that the mutant is less well inhibited by antibodies
A protein involved in making cells move offers a clue to how certain types of cancer metastasize and develop into secondary tumours, according to new research from the University of Warwick.
Whether summer or winter, midnight sun or polar night - the sand on the ocean floor is always inhabited by the same bacteria. Although the microbial communities differ between different ocean regions, they do not change between the seasons. Presumably, there is simply no room for change. Researchers at the Max Planck Institute for Marine Microbiology in Bremen, Germany, now describe this phenomenon in a study published in the journal ISME Communications.