Salk scientists developed a new model for glioblastoma using gene-edited organoids.
Researchers investigating a key signaling protein in Huntington's disease describe deleterious effects on heart function, going beyond the disease's devastating neurological impact. By adjusting protein levels affecting an important biological pathway, the researchers improved heart function in experimental animals, shedding light on the biology of this fatal disease.
An interdisciplinary team of researchers has identified a new gene linked to human aortic aneurysms.
Researchers have incorporated therapeutic microRNAs (miRNAs) into bioresorbable, silk-based medical devices such as screws and plates to achieve local delivery of factors that can improve bone growth and mineralization at the site of bone repair.
A review of research on induced pluripotent stem cells (iPSCs) finds that donor age does not appear to influence their functionality. This validates iPSCs as a viable alternative to embryonic stem cells in regenerative medicine, and highlights the enormous potential of iPSCs derived from elderly patients to treat their age-related diseases.
A Danish-German research team has shown that not only the where and when of long non-coding RNA expression is important for their function but also the how. The results can have a big impact on our understanding of dynamic regulation of gene expression in biological processes.
A series of outstanding, well illustrated reviews by leading experts in osteoimmunology provide new insights and point to future directions in one of the most rapidly evolving areas of research within the bone field.
Why animals avoid dangers by sensing some 'signs' possibly related to the danger? A simple form of this phenomenon is called 'fear conditioning,' which is a type of learning commonly seen in every animal on the earth. By manipulating activity of specific neurons of the zebrafish brain, scientists at the National Institute of Genetics in Japan have elucidated a neuronal population essential for fear conditioning in zebrafish.
Scientists from EMBL Rome have identified the population of nerve cells in the skin that are responsible for sensitivity to gentle touch, and which cause severe pain in neuropathic pain patients. The team developed a light-sensitive chemical that selectively binds to this type of nerve cell. By first injecting the affected skin area with the chemical and then illuminating it with near-infrared light, the targeted cells retract from the skin's surface, leading to pain relief.
A team of scientists from Arizona State University's School of Molecular Sciences has begun re-thinking the evolutionary history of photochemical reaction centers (RCs). Their analysis was recently published online in Photosynthesis Research and describes a new pathway that ancient organisms may have taken to evolve the great variety of photosynthetic RCs seen today across bacteria, algae, and plants. The study will go into print later this summer in a special issue dedicated to photochemical reaction centers.