"This discovery furthers our understanding of how Borrelia burgdorferi causes inflammation and disease," said Mari Davis, who is the lead author on the paper, a former master's graduate of the Jutras lab in the Department of Biochemistry in the College of Agriculture and Life Sciences. "It is a testament to how unique that this bacterium is -- and how we need to keep working to understand more about what is going on behind the scenes in order to develop future diagnostics and treatments."
We retrospectively reviewed clinical information of pediatric patients whose CSF was analyzed for NMDAR antibodies, and evaluated the 2016 diagnostic criteria for anti-NMDA receptor encephalitis. The criteria showed high sensitivity but low positive predictive value in our cohort. However, majority of the false positive cases were associated with a neuroimmunological disease. Collectively, physicians should start immunomodulatory therapy in the criteria-positive cases, but continue differential diagnosis, focusing especially on other forms of encephalitis.
The research group created a virus capable of acting on specific adult brain regions, helping to elucidate the role of key neurons in the prefrontal cortex. They tested the technique on mice.
Conclusion was drawn from a study that involved 92 adolescents aged 11-18. The findings underscore the importance of considering differences between the sexes when treatment is planned.
Individuals with diabetes are at greater risk of developing oral health issues, like gum disease, yet care for these linked health issues are usually disconnected, split between primary care and dental care. A research team from the University of Amsterdam developed an intervention that provided primary care-based oral health information and dental referrals for patients with diabetes.
It's widely understood that people taking a common class of antibiotics, like ciprofloxacin and levofloxacin, run the risk of tendonitis and tendon ruptures. However, a new analysis sheds light on newer, third-generation fluoroquinolones and suggests they may have a lower risk of Achilles tendon rupture.
COVID-19 patients who receive oxygen therapy or experience fever show reduced gray matter volume in the frontal-temporal network of the brain, according to a new study led by researchers at Georgia State University and the Georgia Institute of Technology. The study's findings demonstrate changes to the frontal-temporal network could be used as a biomarker to determine the likely prognosis of Covid-19 or evaluate treatment options for the disease.
Researchers found that the process of activation of stem cells in the brain responsible for the production of neurons (nerve cells) is not random, but coordinated. According to the researchers, these findings are very important for understanding the proper development of the brain. The findings may form the basis for the development of future treatments using brain stem cells, such as for brain cancer, neurodegenerative diseases like Alzheimer's and Parkinson's, and various brain injuries.
Surprising findings can help improve organoid cultures, explain role of GSK3-beta in brain development
The brain alters our sense of time to synchronize our joint perception of sound and vision. A new study finds that this recalibration depends on brain signals constantly adapting to our environment to sample, order and associate competing sensory inputs together.