Ryerson University Physicist Dr. Michael Kolios, his former graduate student Dr. Michael Moore, and collaborator zebrafish model expert Dr. Xiao-Yan Wen developed a new mode of photoacoustic imaging called F-mode. This new mode selectively enhances photoacoustic image features based on the size of the object and the sounds it produces.
A new article explores the pathophysiological factors that link sleep disturbances and Alzheimer's disease. Better understanding of this connection may lead to potential diagnostics and therapeutics for Alzheimer's disease, and other neurodegenerative diseases and dementia. The article is published ahead of print in the Journal of Neurophysiology (JNP).
Weeds often emerge at the same time as vulnerable crop seedlings and sneak between plants as crops grow. How do farmers kill them without harming the crops themselves? In a new University of Illinois study, researchers identify genes and metabolic pathways responsible for safener efficacy in grain sorghum.
Even when chronic myelogenous leukemia is in remission, 'sleeper cell,' quiescent leukemic stem cells are maintained in microenvironments in the bone marrow. This maintenance is poorly understood. Researchers now describe how niche-specific expression of a particular chemokine by a particular type of bone marrow cell controls quiescence of these treatment-resistant leukemic stem cells. The chemokine is CXCL12, and the particular bone marrow cells expressing it are mesenchymal stromal cells.
A UCLA-led study confirms what women approaching menopause have long suspected: menopause does make fat go up. The study finds that women undergoing perimenopause lost lean body mass and more than doubled their fat mass. The research demonstrates that body mass index (BMI) is a very important clinical tool for predicting health events, such as getting diabetes or having cardiovascular disease -- but is a less useful gauge of cardio-metabolic risk in older women.
Seychelles warblers live and breed in family groups on the tiny island of Cousin. In each group, a dominant female and male reproduce. When helpers assist the with incubation and feeding of chicks, the dominant female breeders age more slowly and live longer, a study by biologists from the University of Groningen and colleagues shows. The results indicate how cooperative breeding -- which also occurs in other species, including humans -- can increase life span.
Immune cells called inflammatory monocytes are often one of the first responders to infections, but they actually facilitate the progression of Cryptococcus neoformans infection in mice, according to a study published March 21 in the open-access journal PLOS Pathogens by Lena Heung and Tobias Hohl of Memorial Sloan Kettering Cancer Center. According to the authors, these disparate results indicate that inflammatory monocytes possess a plasticity of function that can regulate infection outcomes, making them an important target for immunomodulatory therapies against C. neoformans.
The dramatic difference in gonad size between honey bee queens and their female workers in response to their distinct diets requires the switching on of a specific genetic program, according to a new study publishing March 21 in open-access journal PLOS Biology by Annika Roth and Martin Beye of Heinrich-Heine University in Dusseldorf and colleagues. The finding may aid analysis of the interplay of genes and nutrition that drive caste dimorphism in honey bees.
Androgens stimulate prostate cancer cells to grow. Many drugs to target that cancer focus on stopping androgen biosynthesis or blocking the androgen receptor, or AR. Researchers have discovered a new function of the AR in prostate cells -- the AR is imported into and localizes to mitochondria of the cell, where it plays a novel role in regulating multiple mitochondrial processes.
Researchers at Eindhoven University of Technology and Utrecht University have discovered the parameters that govern the encapsulation of drugs. This gives more control over the slow and steady release of drugs in patients. Moreover, designing encapsulations for new drugs will now require far less experimentation which makes for faster and cheaper drug development. The researchers believe this work will have a significant impact on the biomedical field and designing future drugs.