For the first time, scientists have identified compounds found in coffee which may inhibit the growth of prostate cancer. This is a pilot study, carried out on drug-resistant cancer cells in cell culture and in a mouse model; it has not yet been tested in humans. This work is presented at the European Association of Urology congress in Barcelona, after publication in the peer-reviewed journal The Prostate* (this press release contains additional material).
Harvard Medical School investigators have developed a machine learning approach using high-quality, large-scale animal model data that sheds new light on the biology of the liver and kidneys after toxin exposure.
Using roundworms, one of Earth's simplest animals, Rice University bioscientists have found the first direct link between a diet containing too little vitamin B12 and an increased risk of infection by two potentially deadly pathogens.
A series of in vitro toxicology tests provide evidence that British American Tobacco's novel vaping product produces greatly reduced mutagenicity, cytotoxicity and effects on wound healing as compared to cigarette smoke.
The UK's wild newt populations seem to be free from a flesh-eating lethal fungus known to be prevalent in privately-owned amphibians across Western Europe, a nationwide investigation has found.
The French Agency for Food, Environmental and Occupational Health & Safety (ANSES) has published a comprehensive report on hazardous substances in disposable panty diapers on Jan. 23, 2019, entitled 'Sécurité des couches pour bébé.' Here, the German Federal Institute for Risk Assessment (BfR) evaluated the results of this report. However, a complete and conclusive assessment is currently impossible, as important detailed information of technical nature is not available to the BfR.
To enable the study of renal reabsorption outside the human body, a team at the Wyss Institute created a 3D vascularized proximal tubule and used it to measure the transport of glucose from the proximal tubule to the blood vessels, along with the effects of hyperglycemia, a condition associated with diabetes in patients.
As cultural successors, hedgehogs reside in close proximity to humans. Road traffic, lawn mowers and infectious agents threaten the prickly insect eaters. Some infectious agents can be transmitted to humans. Considerate treatment of wildlife and appropriate hygiene measures minimize the risk of infection, though. A study published in 'Emerging Microbes & Infections' by five federal state laboratories and the Leibniz-IZW identified Corynebacterium ulcerans -- a close relative of the diphtheria causing bacterium -- in hedgehogs.
New research conducted by Imperial Brands suggests that toxicants of notable public health interest are substantially reduced in the aerosol from our heated tobacco product (HTP) prototype, compared to smoke from a standard reference cigarette.
Nicotine induces widespread adverse effects on human embryonic development at the level of individual cells, researchers report Feb. 28 in the journal Stem Cell Reports. Single-cell RNA sequencing of human embryonic stem cell (hESC)-derived embryoid bodies revealed that three weeks of nicotine exposure disrupts cell-to-cell communication, decreases cell survival, and alters the expression of genes that regulate critical functions such as heart muscle-cell contractions.