Millions of people have contracted Zika and chikungunya virus infections since the outbreaks that have been striking Latin America since 2013. Particularly Zika-related malformations in newborns warrant reliable diagnostics. DZIF scientists from the Charité - Universitätsmedizin Berlin demonstrate the problems with the currently available diagnostics, particularly for Zika virus detection, and develop combined testing methods that have higher reliability.
A new study in Science challenges long-held theories of why a common virus -- cytomegalovirus, or CMV -- can reactivate and become a life-threatening infection in people with a compromised immune system, including blood cancer patients undergoing bone marrow transplantation.
Despite recommendations first issued more than a decade ago, antibiotics are still routinely prescribed in US emergency rooms for infants with bronchiolitis, a common viral lung infection. Published in the Journal of the Pediatric Infectious Diseases Society, the findings highlight a concerning lag in translating evidence-based guidelines into clinical practice and underscore the need to continue educating health care providers and the public about appropriate antibiotic use.
A cellular protein that interacts with invading viruses appears to help enable the infection process of the Zika virus, according to an international team of researchers who suggest this protein could be a key target in developing new therapies to prevent or treat Zika virus infection.
Scientists have developed a combination of monoclonal antibodies that protected animals from all three Ebola viruses that cause human disease. Their work is described in two companion studies published online in Cell Host & Microbe. The antibody 'cocktail,' called MBP134, is the first experimental treatment to protect monkeys against Ebola virus (formerly known as Ebola Zaire), as well as Sudan virus and Bundibugyo virus, and could lead to a broadly effective therapeutic.
In a first for plant virology, a team from CIRAD recently used nanopore technology to sequence the entire genomes of two yam RNA viruses. This as yet little-used but promising molecular biology technique paves the way for new tools for field diagnosis of plant, animal and human diseases. A godsend for developing countries.
Madariaga virus (MADV), or South American eastern equine encephalitis virus (EEEV), has -- until now -- been found primarily in animals of South and Central America, with the first human outbreak occurring in Panama in 2010. Now, scientists writing in PLOS Neglected Tropical Diseases report the identification of MADV in eight children in Haiti in 2015 and 2016.
Specific respiratory microbiome communities may be linked to influenza susceptibility, according to a study published Jan. 9, 2019 in the open-access journal PLOS ONE by Betsy Foxman from the University of Michigan, USA, and colleagues.
There is a new medication that in one dose successfully protected nonhuman primates against a lethal infection of all strains of the deadly Ebola virus.
Patients with cystic fibrosis are often infected by pseudomonas aeruginosa, a bacterium that infects the lungs and prevents breathing, often causing death. P. aeruginosa itself can also be infected by viruses, which can affect the clinical outcomes of cystic fibrosis patients. University of Illinois Professor of Microbiology Rachel Whitaker and her team had the idea to use P. aeruginosa as a kind of 'model system' for understanding how bacteria's interactions with viruses may affect human health.