An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body's own capacity to fight malignancies by activating an inflammation process that counter's the ability of cancer cells to evade the immune system.
For the first time, scientists have used Positron Emission Tomography (PET) imaging to study brain inflammation following Zika virus infection in mice, according to a study recently published online in Molecular Imaging and Biology. Traditional methods of infectious disease research using animal models provide limited information about disease progression until the study's endpoint, when investigators can analyze tissues from those animals. Imaging studies allow longitudinal studies of the same animal during the course of infection.
Insects and plants have an important ancient defense mechanism that helps them to fight viruses. This is encoded in their DNA. Scientists have long assumed that vertebrates -- including humans -- also had this same mechanism. But researchers at KU Leuven (University of Leuven), Belgium, have found that vertebrates lost this particular asset in the course of their evolution.
Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.
St. Jude Children's Research Hospital investigators report preventive antibiotic therapy, particularly with levofloxacin, reduced the odds of infections in at-risk pediatric leukemia patients early in cancer treatment.
Whether a community is made up of people who spend their days entirely outside or those who rarely see sunshine, the amount of time residents spend outdoors can affect how Zika virus spreads throughout the population. That's the conclusion of a new study conducted in Miami-Dade County, Fla., and published this week in PLOS Neglected Tropical Diseases.
Cryptosporidiosis, a parasitic disease affecting the small intestine and possibly our airways, is a common cause of diarrhea in HIV-positive patients. Now Kazeem Oare Okosun from Vaal University of Technology in South Africa, together with colleagues from Pakistan and Nigeria, has developed a new model and numerical simulations to determine the optimal combination of prevention and treatment strategies for controlling both diseases in patients who have been co-infected. It is published in EPJ Plus.
An international team of researchers has demonstrated a way of overcoming one of the major stumbling blocks that has prevented the development of a vaccine against HIV: the ability to generate immune cells that stay in circulation long enough to respond to and stop virus infection.
A discovery by Melbourne researchers has solved a longstanding mystery of how viruses trigger protective immunity within our body. The research team demonstrated a protein called SIDT2 was crucial for cells to detect viral components in their environment, and initiate an immune response to reduce the virus' spread.
Patients with head and neck cancer who are also positive for human papilloma virus (HPV) are known to have a better prognosis compared to patients with HPV-negative disease, independent of therapeutic intervention. Researchers at the Medical University of South Carolina Hollings Cancer Center have discovered one reason why and have identified a peptide that, in preclinical studies, can act on the identified mechanism to improve outcomes in HPV-negative head and neck cancer.