Human immunodeficiency virus (HIV)-1 may have evolved to integrate its genetic material into certain immune-cell-activating genes in humans, according to new research published in PLOS Pathogens.
Rising global temperatures and changes to land use have both been shown to have profound impacts on human health. Now researchers, reporting in PLOS Neglected Tropical Diseases, have found one more infectious disease that's expected to be affected. By 2050, the number of people in risk of hantavirus in the Brazilian state of Sao Paulo, they found, will increase by more than 20 percent due to climate change and land use changes.
It lives in boiling acid that dissolves flesh and bone. Now scientists have unlocked the secrets of the indestructible virus, potentially allowing them to harness its remarkable properties to create super-durable materials and better treat disease.
In the rats that roam New York City's streets and tunnels, scientists have found a virus that resembles hepatitis C. They have used it to create the first animal model of the human disease, a breakthrough that potentially could yield a much-needed vaccine.
Medical professor Christopher Rudd and his research team have identified a key new mechanism that regulates the ability of T-cells of the immune system to react against foreign antigens and cancer.
It took two years on a supercomputer to simulate 1.2 microseconds in the life of the HIV capsid, a protein cage that shuttles the HIV virus to the nucleus of a human cell. The 64-million-atom simulation offers new insights into how the virus senses its environment and completes its infective cycle.
Researchers led by Martin Jinek of the University of Zurich have found an unprecedented defense mechanism by which bacteria defend themselves against invading viruses. When the bacterial immune system gets overwhelmed, the CRISPR-Cas system produces a chemical signal that activates a second enzyme which helps in degrading the invaders' genetic material. This process is very similar to an antiviral mechanism of the human innate immune system.
Scientists at the University of Washington have discovered a simple way to raise the accuracy of diagnostic tests for medicine and common assays for laboratory research. By adding polydopamine -- a material that was first isolated from shellfish -- to these tests at a key step, the team could increase the sensitivity of these common bioassays by as many as 100 to 1,000 times.
Researchers led by St. Jude Children's Research Hospital have identified a genetic variation associated with influenza severity and the supply of killer T cells that help patients fight the infection.
A study involving 65 people who live in and around São José do Rio Preto (São Paulo State, Brazil), where dengue is endemic and there was a particularly rapid outbreak of Zika during the 2016 epidemic, show that prior dengue infection in human beings infected by Zika does not necessarily lead to a worse illness.