In a new study published in the scientific journal PNAS, Shomyseh Sanjabi, PHD, and her team at the Gladstone Institutes identified two molecules, Sprouty 1 and Sprouty 2, that modify the survival of effector T cells and the development of memory CD8 T cells. Their findings offer promising potential for immunotherapeutic strategies to combat cancer and chronic infections.
Chronic active Epstein-Barr virus infection (CAEBV) is an inflammatory disorder with potential for tumor development. Here, unusual phosphorylation was observed on STAT3 in EBV-infected T- or NK-cells from patients with CAEBV. Tokyo Medical and Dental University(TMDU) researchers found that ruxolitinib, a drug that is currently used for treatment of myelofibrosis and polycythemia vera, could suppress the survival of these EBV-infected cells in a dose-dependent manner, and that STAT3 could be an important new target for treatment of CAEBV.
The deadly Nipah virus and others like it assemble themselves in a much more haphazard manner than previously thought, new UBC research has found. The discovery could allow scientists to develop more effective vaccines and rule out many approaches to fighting these viruses.
'For me, as a functional genomics and genetics researcher, having a continuous and fully annotated sequence for each of the 21 wheat chromosomes is of paramount importance,' says Kostya Kanyuka who, with bioinformatician Rob King, represented Rothamsted Research in the IWGSC. 'This will greatly speed up our efforts on identification of agriculturally important wheat genes, including those that would help to combat major fungal diseases.'
A study aiming at the development of a dengue vaccine shows that the prevalence of a virus lineage upon the other does not rely on the highest replication rate: it is rather based on the virus' ability in triggering weaker activation of the patient's immune response.
A plant virus with a simple genome promises to help crop scientists understand traits and diseases in wheat and maize more quickly and easily than existing techniques and, as its full potential is tapped, to work across a range of different plant species.
A one-two punch of powerful antibodies may be the best way to stop Ebola virus, reports an international team of scientists in the journal Cell.
Nature study found naturally-occurring compound inositol hexakisphosphate (IP6) promotes both assembly and maturation of HIV-1. NSF-XSEDE allocations on the Stampede2 supercomputing system at the Texas Advanced Computing Center and on Anton2 at the Pittsburgh Supercomputing Center simulated atomistic interactions of IP6 molecule with HIV structural proteins. Research opens door for development of new treatments of HIV-1 virus.
New research provides details of how the structure of the HIV-1 virus is assembled, findings that offer potential new targets for treatment.
"We can now watch antibody responses evolve almost in real time," says Lars Hangartner, Ph.D., a Scripps Research associate professor.